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Horm Metab Res 1982; 14(10): 505-507
DOI: 10.1055/s-2007-1019062
© Georg Thieme Verlag, Stuttgart · New York

Improvement of Artificial Endocrine Pancreas (Biostator; GCIIS) Performance Combining Feedback Controlled Insulin Administration with a Pre-Programmed Insulin Infusion

G. Calabrese, A. Bueti, G. Zega, A. Giombolini, G. Bellomo, M. A. Antonella, M. Massi-Benedetti, P. Brunetti
  • Institute of Medical Pathology, University of Perugia, Perugia, Italy
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1981

1982

Publikationsdatum:
14. März 2008 (online)

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Summary

It is well known that the glycemic control accomplished by the artificial endocrine pancreas (Biostator; GCIIS), requires an excessive insulin consumption.

In order to improve the Biostator performance, we have studied 5 insulin dependent diabetic patients on anticipated automatic pre-programmed insulin infusion starting at the beginning of breakfast. Such an operating method allowed us to obtain a significant reduction in insulin requirements (from 17,3 ± 2,2 U to 13,3 ± 2,2 U), and a better glycemic control (MBG 98,7 ± 5,4 vs 111,1 ± 5,6; M 2,34 ± 0,9 vs 6,96 ± 1,7; Δ G 43,8 ± 3 vs 73,4 ± 9,7), as compared to those observed under conventional feed-back control in relation to breakfast.

Key-Words:

Diabetes Mellitus - Biostator - Pre-Programmed Insulin Infusion

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