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Horm Metab Res 1980; 12(1): 23-25
DOI: 10.1055/s-2007-996187
© Georg Thieme Verlag, Stuttgart · New York

The Significance of the Na+/K+ Pump for Somatostatin Release

K. Hermansen, S. E. Christensen, H. Ørskov
  • Second University Clinic of Internal Medicine, Kommunehospitalet, Aarhus, Denmark
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Publikationsverlauf

1979

1979

Publikationsdatum:
22. April 2008 (online)

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Summary

The influence of the Na+/K+ pump on somatostatin secretion from the isolated perfused canine pancreas was investigated. The somatostatin secretion was reversibly increased in response to addition of ouabain (10-5 mol/l) and to omission of extracellular K+, procedures which are known to cause a blockade of the Na+/K+ pump. The stimulatory effect on somatostatin release was abolished during calcium depletion.

The results suggest that the operation of the Na+/K+ pump plays an important role for the somatostatin secretion. The action of the Na+/K+ pump on the secretory function of the D-cells is dependent on the presence of extracellular calcium.

Key-Words

Perfused Pancreas - Somatostatin - Sodium-Potassium - Calcium

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