Do miRNAs Have a Role in Platelet Function Regulation?

A. Garcia; Sylvie Dunoyer-Geindre; P. Fontana

doi:10.1055/a-1478-2105

Hämostaseologie, Table of Contents

Hamostaseologie 2021; 41(03): 217-224
DOI: 10.1055/a-1478-2105

Review Article

Do miRNAs Have a Role in Platelet Function Regulation?

Authors

A. Garcia

¹Geneva Platelet Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Sylvie Dunoyer-Geindre

¹Geneva Platelet Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland
P. Fontana

¹Geneva Platelet Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland

²Division of Angiology and Haemostasis, Geneva University Hospitals, Geneva, Switzerland

Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs known to repress mRNA translation and subsequent protein production. miRNAs are predicted to modulate many targets and are involved in regulating various cellular processes. Identifying their role in cell function regulation may allow circulating miRNAs to be used as diagnostic or prognostic markers of various diseases. Increasing numbers of clinical studies have shown associations between circulating miRNA levels and platelet reactivity or the recurrence of cardiovascular events. However, these studies differed regarding population selection, sample types used, miRNA quantification procedures, and platelet function assays. Furthermore, they often lacked functional validation of the miRNA identified in such studies. The latter step is essential to identifying causal relationships and understanding if and how miRNAs regulate platelet function. This review describes recent advances in translational research dedicated to identifying miRNAs' roles in platelet function regulation.

Keywords

microRNA - platelet function - biomarker

Full Text

References

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