New Insights into the Copper-Catalyzed Alkylation of Grignard and Organolithium Reagents

Abstract

Until now, it was considered that the copper-catalyzed alkylation of Grignard reagents gave good yields only in the presence of ligands, such as NMP or 1-phenylpropyne. We show herein that a slow and regular addition of the Grignard reagent provides similar results. With secondary and tertiary alkyl Grignard reagents, we disclosed that the presence of benzonitrile (10 mol%), a very simple ligand, is very efficient. The copper-catalyzed alkylation of organolithium compounds was also studied.

alkylations - copper - cross-coupling - Grignard reactions - organometallic reagents

References and Notes

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