Adulter Morbus Still

Zusammenfassung

Der adulte Morbus Still ist eine seltene entzündliche Systemerkrankung. Leitsymptome/-manifestationen sind Fieber, Arthralgien oder Arthritis, Myalgien, ein typischer Hautausschlag, Halsschmerzen, Hepatosplenomegalie, Lymphadenopathie und Serositis. Zahlreiche weitere Symptome und Organmanifestationen sind jedoch möglich. Das klinische Erscheinungsbild ist variabel und kann leicht bis lebensbedrohlich ausgeprägt sein. Der Erkrankungsverlauf ist spontan-limitierend, intermittierend oder chronisch. Da ein beweisendes diagnostisches Testverfahren nicht vorhanden ist, kann die Diagnose erst nach Ausschluss zahlreicher, vor allem infektiöser, maligner und autoimmuner Differentialdiagnosen gestellt werden. Zur Therapie können nichtsteroidale Antiphlogistika, Glucocorticoide, Basistherapeutika und Biologika eingesetzt werden.

Abstract

Adult-onset Still’s disease is a rare inflammatory systemic disease. Cardinal symptoms/manifestations are fever, arthralgias or arthritis, myalgias, the typical skin rash, sore throat, hepatosplenomegaly, lymphadenopathy and serositis. Several other symptoms and organ involvements are possible. The clinical picture is variable with mild to life-threatening courses. The disease is self-limiting, intermittently active or chronic. Because of the lack of a defined diagnostic test the diagnosis of AOSD can only be made after exclusion of several differential diagnoses in particular of infectious, malignant and autoimmune origin. For therapy non-steroidal anti-inflammatory drugs, glucocorticoids, disease modifying antirheumatic drugs and biologics can be used.

Schlüsselwörter

adulter Morbus Still - Morbus Still des Erwachsenen - adult-onset Still’s disease (AOSD)

Keywords

Still’s disease - adult-onset Still’s disease - AOSD

Literatur

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