Physical Inactivity is a Major Contributor to Ovariectomy-Induced Sarcopenia

H. Fonseca; S. K. Powers; D. Gonçalves; A. Santos; M. P. Mota; J. A. Duarte

doi:10.1055/s-0031-1297953

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2012; 33(04): 268-278
DOI: 10.1055/s-0031-1297953

Physiology & Biochemistry

Physical Inactivity is a Major Contributor to Ovariectomy-Induced Sarcopenia

Authors

H. Fonseca

¹FADEUP, Biochemistry, Porto, Portugal
S. K. Powers

²Applied Physiology, University of Florida, Gainesville, United States
D. Gonçalves

³Biochemistry of Sports, FADEUP, Porto, Portugal
A. Santos

⁴Faculty of Sports, CIAFEL, Porto, Portugal
M. P. Mota

⁵Department of Sport, University of Tras-os-Montes e Alto Douro, Vila Real, Portugal
J. A. Duarte

⁶Sport Biology, University of Porto, Portugal

Abstract

Since the mechanism(s) underlying menopause-related sarcopenia remain unknown we aimed to investigate the role of physical inactivity in its etiology. Ovariectomized and sham-operated rats were allocated into 2 experimental groups: 1) sedentary-standard housing; and 2) exercise-housed with running wheel. After a 9-month experimental period, soleus muscle structure and biochemical properties were analyzed. No differences existed in muscle fibre size or ultrastructure between sedentary sham and ovariectomized animals housed in standard conditions. In the exercise groups, average daily running distance was 10-fold less in ovariectomized compared to sham-animals. Further, in exercised animals, soleus fibre size was smaller in ovariectomized compared to sham-animals. Nonetheless, compared to both sedentary groups, muscle fibre size was larger in the exercised ovariectomized animals. Our results indicate that ovariectomy-induced sarcopenia is not due to the loss of ovarian hormones per se, but is largely due to physical inactivity.

Key words

voluntary running - menopause - sedentary behaviour - atrophy - estrogen - skeletal muscle loss

Full Text

References

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