Syntheses of Fawcettimine-Type Lycopodium Alkaloids Utilizing the Pauson–Khand Reaction

Atsushi Nakayama; Mariko Kitajima; Hiromitsu Takayama

doi:10.1055/s-0032-1316680

Synlett, Inhaltsverzeichnis

Synlett 2012; 23(14): 2014-2024
DOI: 10.1055/s-0032-1316680

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Syntheses of Fawcettimine-Type Lycopodium Alkaloids Utilizing the Pauson–Khand Reaction

Atsushi Nakayama

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan, Fax: +81(43)2262914 eMail: htakayam@p.chiba-u.ac.jp

,

Mariko Kitajima

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan, Fax: +81(43)2262914 eMail: htakayam@p.chiba-u.ac.jp

,

Hiromitsu Takayama*

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan, Fax: +81(43)2262914 eMail: htakayam@p.chiba-u.ac.jp

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Abstract

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Abstract

The asymmetric total syntheses of some fawcettimine-type Lycopodium alkaloids, utilizing an intramolecular Pauson–Khand reaction as the key step, are described.

1 Introduction

2 First Asymmetric Total Syntheses of Lycoposerramine-C and Phlegmariurine A

3 First Asymmetric Total Synthesis of Huperzine Q

4 Total Syntheses of Fawcettimine and Fawcettidine

5 Conclusion

Key words

alkaloids - total synthesis - asymmetric synthesis - fawcettimine - Pauson–Khand reaction

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Referenzen

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