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Horm Metab Res 2013; 45(07): 477-484
DOI: 10.1055/s-0033-1334945
DOI: 10.1055/s-0033-1334945
Review
An Active Role for Steroid-binding Globulins: An Update
Weitere Informationen
Publikationsverlauf
received 20. Dezember 2012
accepted 05. Februar 2013
Publikationsdatum:
02. April 2013 (online)
Abstract
It has been 7 years (can it really be that long?) since we co-edited a volume (#38) of Hormone and Metabolic Research that focused on evidence that steroid-binding globulins play an active role in the actions of steroids. There has been considerable progress in identifying the location, the physiological actions, and of determining the role of binding globulins in the actions of steroids and identifying a membrane-associated receptor for a binding protein since then and this review will discuss this progress.
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References
- 1 Wang YM, Bayliss DA, Millhorn DE, Petrusz P, Joseph DR. The androgen-binding protein gene is expressed in male and female rat brain. Endocrinology 1990; 127: 3124-3130
- 2 Caldwell JD, Suleman F, Chou SH-H, Shapiro RA, Herbert Z, Jirikowski GF. Emerging Roles of Steroid Binding Globulins. Horm Metab Res 2006; 38: 206-218
- 3 Gao G, Herbert Z, Kong J, Wu D, Gabrielson N, Jirikowski GF, Caldwell JD. Estradiol Control of Estradiol Binding Proteins and Levels in the Medial Preoptic Area, Medial Hypothalamus and Pituitary. Neuroendocrinology 2003; 78: 61-71
- 4 Herbert Z, Jirikowski GF, Petrusz P, Englof I, Caldwell JD. Distribution of androgen binding globulin in the rat hypothalamo-hypophyseal system, co-localization with oxytocin. Brain Res 2003; 992: 151-158
- 5 Herbert Z, Pollak EI, Caldwell JD, Jirikowski GF. Subcellular localization of SHBG in rat hypothalamus and pituitary. Soc Neurosci Abs 2003; 610: 3
- 6 Herbert Z, Gothe S, Caldwell JD, Bernstein HG, Melle C, Lewis J, Jirikowski GF. Characterization of sex hormone binding globulin (SHBG) in the human hypothalamus. Neuroendocrinology 2005; 81: 286-293
- 7 Sendemir E, Herbert Z, Caldwell JD, Jirikowski GF. Localization of sex hormone binding globulin in the hypothalamus of late pregnant and early lactating rats. Horm Metab Res 2006; 38: 219-224
- 8 Jirikowski GF. Oxytocinergic neuronal systems during mating, pregnancy, parturition, and lactation. Ann N Y Acad Sci 1992; 652: 253-270
- 9 Jirikowski GF, Caldwell JD, Pilgrim C, Stumpf WE, Pedersen CA. Changes in immunostaining for oxytocin in the forebrain of the female rat during late pregnancy, parturition and early lactation. Cell Tissue Res 1989; 256: 411-417
- 10 Caldwell JD, Greer ER, Johnson MF, Prange Jr AJ, Pedersen CA. Oxytocin and vasopressin immunoreactivity in hypothalamic and extrahypothalamic sites in late pregnant and postpartum rats. Neuroendocrinology 1987; 46: 39-47
- 11 Schock HW, Herbert Z, Sigusch H, Figulla HR, Jirikowski GF, Lotze U. Expression of androgen-binding protein (ABP) in human cardiac myocytes. Horm Metab Res 2006; 38: 225-229
- 12 Selva DM, Hammond GL. Human Sex Hormone Binding Globulin is expressed in Testicular Germ Cells and not in Sertoli Cells. Horm Metab Res 2006; 38: 230-235
- 13 Hammond GL. Diverse Roles for Sex Hormone-Binding Globulin in Reproduction. Biol Reprod 2011; 185: 431-441
- 14 Mopert B, Herbert Z, Caldwell JD, Jirikowski GF. Expression of Corticosterone Binding Globulin CBG in the rat hypothalamus. Horm Metab Res 2006; 38: 246-252
- 15 Fortunati N, Catalano M. Sex hormone-binding globulin (SHBG) and estradiol cross-talk in breast cancer cells. Horm Metab Res 2006; 38: 236-240
- 16 Sivukhina EV, Jirikowski GF, Bernstein HG, Lewis JG, Herbert Z. Expression of corticosteroid-binding protein in the human hypothalamus, co-localization with oxytocin and vasopressin. Horm Metab Res 2006; 38: 253-259
- 17 Breuner CW, Lynn SE, Julian GE, Cornelius JM, Heidinger BG, Love OP, Sprague RS, Wada H, Whitman BA. Plasma binding globulins and the acute stress response. Horm Metab Res 2006; 38: 260-268
- 18 Redondo C, Burke BJ, Findlay JB. The Retinol Binding Protein System: A potential paradigm for steroid binding globulins?. Horm Metab Res 2006; 38: 269-278
- 19 Andreassen TK. The role of plasma-binding proteins in the cellular uptake of vitamins and steroids. Horm Metab Res 2006; 38: 279-290
- 20 Caldwell JD, Shapiro RA, Jirikowski GF, Suleman F. Internalization of sex hormone-binding globulin into neurons and brain cells In vitro and In vivo. Neuroendocrinology 2007; 86: 84-93
- 21 Hryb DJ, Khan MS, Romas NA, Rosner W. The control of the interaction of sex hormone-binding globulin with its receptor by steroid hormones. J Biol Chem 1990; 265: 6048-6054
- 22 Piskunov A, Rochette-Egly C. A retinoic acid receptor RARalpha pool present in membrane lipid rafts forms complexes with G protein alphaQ to activate p38MAPK. Oncogene 2012; 31: 3333-3345
- 23 Chambliss KL, Shaul PW. Estrogen modulation of endothelial nitric oxide synthase. Endocrine Rev 2002; 23: 665-686
- 24 Campos-Sandoval JA, Redondo C, Kinsella GK, Pal A, Jones G, Hirst SC, Findlay JB. Fenretinide derivatives act as disrupters of interactions of serum retinol binding protein (sRBP) with transthyretin and the sRBP receptor. J Med Chem 2011; 54: 4378-4387
- 25 Kawaguchi R, Yu J, Honda J, Hu J, Whitlegge J, Ping P, Wiita P, Bok D, Sun H. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science 2007; 315: 820-825
- 26 Kawaguchi R, Yu J, Ter-Stepanian M, Zhong M, Cheng G, Yuan Q, Jin M, Travis GH, Ong D, Sun H. Receptor-mediated cellular uptake mechanism that couples to intracellular storage. ACS Chem Biol 2011; 6: 1041-1051
- 27 Szeto W, Jiang W, Tice DA, Rubinfeld B, Hollingshead PG, Pennica D. Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. Cancer Res 2001; 61: 4197-4205
- 28 Redondo C, Vouropoulou M, Evans J, Findlay JB. Identification of the retinol-binding protein (RBP) interaction site and functional state of RBPs for the membrane receptor. FASEB J 2008; 22: 1043-1054
- 29 Caldwell JD, Jirikowski GF. Sex hormone binding globulin and aging. Horm Metab Res 2009; 41: 173-182
- 30 Peiris AN, Stagner JI, Plymate SR, Vogel RL, Heck M, Samols E. Relationship of insulin secretory pulses to sex hormone binding globulin in normal men. J Clin Endocrin Metab 1993; 76: 279-282
- 31 Lewis JG, Borowski KK, Shand BI, George PM, Scott RS. Plasma sex hormone-binding globulin, corticosteroid-binding globulin, cortisol, and free cortisol levels in outpatients attending a lipid disorders clinic: a cross-sectional study of 1137 subjects. Horm Metab Res 2010; 42: 274-279
- 32 Slaunwhite WR, Sandberg AA. Transcortin: A corticosteroid-binding protein of plasma. J Clin Invest 1959; 38: 384-391
- 33 Westphal U. Interactions between steroids and proteins. . 454. 1961. U. S. Army Med Res Lab Report
- 34 Gala RR, Westphal U. Relationship between the pituitary gland and the cortico-steroid binding globulin in the rat. Endocrinology 1966; 78: 285
- 35 Gala RR, Westphal U. Studies on the sex difference in corticosteroid-binding activity of rat serum. Fed Proc 1965; 24: 564
- 36 Gala RR, Westphal U. Corticosterone-binding globulin in the rat: Possible role in the initiation of lactation. Endocrinology 1965; 76: 1079-1088
- 37 Gala RR, Westphal U. Corticosteroid-binding globulin in the rat: Studies on the sex difference. Endocrinology 1965; 77: 841-851
- 38 Gala RR, Westphal U. Influence of anterior pituitary hormones on the corticosteroid-binding globulin in the rat. Endocrinology 1966; 79: 55-66
- 39 Al-Khouri H, Greenstein BD. Role of corticosteroid-binding globulin in interaction of corticosterone with uterine and brain progesterone receptors. Nature 1980; 287: 58-60
- 40 Rosenthal HE, Slaunwhite WR, Sandberg AA. Transcortin: A corticosteroid-binding protein of plasma. X. Cortisol and progesterone interplay and unbound levels of these steroids in pregnancy. J Clin Endocr 1969; 29: 352-367
- 41 Petersen HH, Andreassen TK, Breiderhoff T, Braesen JH, Schulz H, Gross V, Groene HJ, Nykjaer A, Willnow TE. Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin. Mol Cell Biol 2006; 26: 7236-7245
- 42 Sorensen MV, Praetorius HA, Nykjaer A, Willnow TE, Leipziger J. Impaired aldosterone responsiveness in corticosteroid binding globulin deficient mice. Acta Physiol (Oxf) 2011; 201: 169-177
- 43 Henley DE, Lightman SL. New insights into corticosteroid-binding globulin and glucocorticoid delivery. Neuroscience 2011; 180: 1-8
- 44 Cizza G, Bernardi L, Smime N, Maletta R, Tomaino C, Bruni AC. Clinical manifestations of highly prevalent corticosteroid-binding globulin mutations in a village in southern Italy. J Clin Endocrinol Metab 2011; 96: E1684-E1693
- 45 Gagliardi L, Ho JT, Torpy DJ. Corticosteroid-binding globulin: the clinical significance of altered levels and heritable mutations. Mol Cell Endocrinol 2010; 316: 24-34
- 46 Joyner JM, Hutley LJ, Bachmann AW, Torpy DJ, Prins JB. Greater replication and differentiation of preadipocytes in inherited corticosteroid-binding globulin deficiency. Am J Physiol Endocrinol Metab 2003; 284: E1049-E1054
- 47 Torpy DJ, Bachmann AW, Grice JE, Fitzgerald SP, Phillips PJ, Whitworth JA, Jackson RV. Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension. J Clin Endocrinol Metab 2001; 86: 3692-3700
- 48 Peckett AJ, Wright DC, Riddell MC. The effects of glucocorticoids on adipose tissue lipid metabolism. Metabolism 2011; 60: 1500-1510
- 49 Thomas P, Zhu Y, Pace M. Progestin membrane receptors involved in the meiotic maturation of teleost oocytes: a review with some new findings. Steroids 2002; 67: 511-517
- 50 Thomas P. Chemical interference with genomic and nongenomic actions of steroids in fishes: role of receptor binding. Mar Environ Res 2000; 50: 127-134
- 51 Thomas P, Pang Y, Dong J, Groenen P, Kelder J, deVlieg J, Zhu Y, Tubbs C. Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins. Endocrinology 2007; 148: 705-718
- 52 Zhu Y, Bond J, Thomas P. Identification, classification and partial characterization of gene in human and other vertebrates homologous to a novel fish membrane progestin receptor. Proc Natl Acad Sci USA 2003; 100: 2237-2242
- 53 Avvakumov GV, Krupenko SA, Strel’chyonok OA. Study of the transcortin binding to human endometrium plasma membrane. Biochim Biophys Acta 1989; 984: 143-150
- 54 Strel’chyonok OA, Avvakumov GV. Interaction of human CBG with cell membranes. J Steroid Biochem Mol Biol 1991; 40: 795-803
- 55 Strel’chyonok OA, Avvakumov GV. Evidence for the presence of specific binding sites for transcortin in human liver plasma membranes. Biochim Biophys Acta 1983; 755: 514-517
- 56 Miska W, Pena P, Villegas J, Sanchez R. Detection of a CBG-like protein in human Fallopian tube tissue. Andrologia 2004; 36: 41-46
- 57 Teves ME, Guidobaldi HA, Unates DR, Sanchez R, Miska W, Giojalas LC. Progesterone sperm chemoattraction may be modulated by its corticosteroid-binding globulin carrier protein. Fertil Steril 2010; 93: 2450-2452
- 58 Miska W, Fehl P, Henkel R. Biochemical and immunological characterization of the acrosome reaction-inducing substance (ARIS) of hFF. Biochem Biophys Res Commun 1994; 199: 125-129
- 59 Caldwell JD. A sexual arousability model involving steroid effects at the plasma membrane. Neurosci Biobehav Rev 2002; 26: 13-30
- 60 Sivukhina EV, Helbling J-C, Minni AM, Schafer HH, Pallet V, Jirikowski GF, Moisan MP. Intrinsic expression of transcortin in neural cells of the mouse brain: A histochemical and molecular study. J Exp Biol 2013; 216(Pt2): 245-252
- 61 Herbert Z, Pollak EI, Molnar L, Caldwell JD, Jirikowski GF. Co-transport of sex hormone binding globulin/SHBG with oxytocin in transport vesicle of the hypothalamo-hypophyseal system. Horm Metab Res 2006; 38: 291-293
- 62 Slater JD, Hartog M, Fraser R, Rantzen B. Dexamethasone suppression test in diagnosis in Cushing’s syndrome. Br Med J 1962; 1: 1584-1586
- 63 Carroll BJ, Martin FI, Davies B. Resistance to suppression by dexamethasone of plasma 11-O.H.C.S. levels in severe depressive illness. Br Med J 1968; 3: 285-287
- 64 Reynolds RM, Bendall HE, Whorwood CB, Wood PJ, Walker BR, Phillips DI. Reproducibility of the low dose dexamethasone suppression test: comparison between direct plasma and salivary cortisol assays. Clin Endocrinol (Oxf) 1998; 49: 307-310
- 65 Rush AJ, Giles DE, Schlesser MA, Orsulak PJ, Parker CR, Weissneburger JE, Crowley GT, Khatami M, Vasavada N. The dexamethasone suppression test in patients with mood disorders. J Clin Psychiatry 1996; 57: 470-484
- 66 Stein MB, Yehuda R, Koverola C, Hanna C. Enhanced dexamethasone suppression of plasma cortisol in adult women traumatized by childhood sexual abuse. Biol Psychiatry 1997; 42: 680-686
- 67 Wiedmann K, Holsboer F. The effect of repeated human corticotropin-releasing hormone administration on dexamethasone-suppressed pituitary-adrenocortical activity in healthy subjects. Biol Psychiatry 1997; 42: 882-888
- 68 Takahishi LR. Role of CRF1 and CRF2 receptors in fear and anxiety. Neurosci Biobehav Rev 2006; 25: 627-636
- 69 Richard EM, Helbing J-C, Tridon C, Desmedt A, Minni AM, Cador M, Pourtau L, Konsmon J-P, Morme P, Moisan MP. Plasma transcortin influences endocrine and behavioral stress responses in mice. Endocrinology 2010; 151: 649-659
- 70 Dolz W, Eitner A, Caldwell JD, Jirikowski GF. Expression of corticosteroid binding globulin in the rat olfactory system. Acta Histochem 2012; epub ahead of publication doi10.1016/j.acthis.2012.09.012
- 71 Beckman M. Pheromone reception. When in doubt, mice mate rather than hate. Science 2002; 295: 782
- 72 Witt M, Woz’niak W. Structure and function of the vomeronasal organ. Adv Otorhinolaryngol 2006; 63: 70-83
- 73 Evans CS. Accessory chemosignaling mechanisms in primates. Am J Primatol 2006; 68: 525-544
- 74 Rapiejko P, Zielnik-Jurkiewicz B, Wojdas A, Ratajczak J, Jurkiewicz D. The existence vomeronasal organ in adult humans. Otolaryngol Pol 2007; 61: 581-584
- 75 Robinson AM, Kern RC, Foster JD, Fong KJ, Pitovski DZ. Expression of glucocorticoid receptor mRNA and protein in the olfactory mucosa: physiologic and pathophysiologic implications. Laryngoscope 1998; 108 (8 Pt 1) 1238-1242
- 76 Ackerl K, Aztmueller M, Grammer K. The scent of fear. Neuroendocrinol Letters 2002; 23: 79-84
- 77 Chen D, Havilland-Jones J. Human olfactory communication of emotion. Percept Mot Skills 2000; 91: 771-781
- 78 Chen D, Katdare A, Lucas N. Chemosignals of fear enhance cognitive performance in humans. Chem Senses 2006; 31: 415-423
- 79 Cocke R, Thiessen DD. Chemocommunication among prey and predator species. Animal Learning Beh 1986; 14: 90-92
- 80 Mujica-Parodi L, Strey HH, Frederick B, Savoy R, Cox D, Botanov Y, Tokunov D, Rubin D, Weber J. Chemosensory cues to conspecific emotional stress activate amygdala in humans. PLoS ONE 2009; 4: 1-14
- 81 Zhou W, Chen D. Fear-Related Chemosignals Modulate Recognition of Fear in Ambiguous Facial Expressions. Psycholog Sci 2009; 20: 177-183
- 82 Berglund H, Lindstrom P, Savic I. Brain response to putative pheromones in lesbian women. Proc Natl Acad Sci USA 2006; 103: 8269-8274
- 83 Glaser SD, Veenstra TD, Jirikowski GF, Prufer K. Distribution of 1,25-dihydroxyvitamin D3 receptor immunoreactivity in the rat olfactory system. Cell Mol Biology 1999; 19: 613-624
- 84 Jirikowski GF. Localization and fuctional implications of steroid binding globulins in the olfactory system. 16th Annual Workshop on Steroid Hormones and Brain Function 2008
- 85 Lewis JG, Elder PA. Corticosteroid-binding globulin reactive centre loop antibodies recognise only the intact natured protein: elastase cleaved and uncleaved CBG may coexist in circulation. J Steroid Biochem Mol Biol 2011; 127: 289-294
- 86 Pemberton PA, Stein PE, Pepys MB, Potter JM, Carrell RW. Hormone binding globulins undergo serpin conformational change in inflammation. Nature 1988; 336: 257-258
- 87 Allera A, Wildt L. Glucocorticoid-recognizing and -effector sites in rat liver plasma membrane. Kinetics of corticosterone uptake by isolated membrane vesicles–II. Comparative influx and efflux. J Steroid Biochem Mol Biol 1992; 42: 757-771
- 88 Pusch L, Wegmann S, Caldwell JD, Jirikowski GF. Expression of Corticosteroid-Binding Globulin in Human Astrocytoma Cell Line. Cellular and Mol Neurobiol 2009; 29: 583-588
- 89 Humphries KH, Izadnegahdar M, Mackay MH. Sex differences in presentation of myocardial infarction. JAMA 2012; 307: 2486-2487
- 90 Leonard FD. Sex differences in presentation of myocardial infarction. JAMA 2012; 307: 2486
- 91 Gasparri C, Curcio A, Torella D, Gaspari M, Celli V, Salituri F, Boncompagni D, Torella M, Guletta E, Cuda G, Indolfi C. Proteomics reveals high levels of vitamin D binding protein in myocardial infarction. Front Biosci (Elite Ed) 2010; 2: 796-804
- 92 Chun RF. New perspectives on the vitamin D binding protein. Cell Biochem Funct 2012; 30: 445-456
- 93 Blanton D, Han Z, Bierschenk L, Linga-Reddy MV, Wang H, Clare-Salzler M, Haller M, Schatz D, Myhr C, She JX, Wasserfall C, Atkinson M. Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes. Diabetes 2011; 60: 2566-2570
- 94 Cho S, Choi YS, Yim SY, Yang HI, Jeon YE, Lee KE, Kin H, Seo SK, Lee BS. Urinary vitamin D-binding protein is elevated in patients with endometriosis. Hum Reprod 2012; 27: 515-522
- 95 Yamamoto N, Lindsay DD, Naraparaju VR, Ireland RA, Popoff SN. A defect in the inflammation-primed macrophage-activation cascade in osteopetrotic rats. J Immunol 1994; 152: 5100-5107
- 96 Wood AM, Bassford C, Webster D, Newby P, Rajesh P, Stockley FA, Thickett DD. Vitamin D-binding protein contributes to COPD by activation of alveolar macrophages. Thorax 2011; 66: 205-210
- 97 Faserl K, Kremser L, Lindner H, Sarg B, Wildt L, Seeber B. Polymorphism in vitamin D-binding protein as a genetic risk factor in the pathogenesis of endometriosis. J Clin Endocrinol Metab 2011; 96: E233-E241
- 98 Gregory KJ, Zhao B, Bielenberg DR, Dridi S, Wu J, Jian W, Huang B, Pirie-Shepherd S, Fannon M. Vitamin D binding protein-macrophage activating factor directly inhibits proliferation, migration, and uPAR expression of prostate cancer cells. PLoS ONE 2010; 5: e13428
- 99 Chisimba L, Thickett DR, Stockley RA, Wood AM. The vitamin D axis in the lung: a key role for vitamin D-binding protein. Thorax 2010; 65: 456-462
- 100 Dimeloe S, Hawrylowicz CM. A direct role for vitamin D-binding protein in the pathogenesis of COPD?. Thorax 2011; 66: 189-190
- 101 Kipp JL, Ramirez VD. Estradiol and testosterone have opposite effects of microtubule polymerization. Neuroendocrinology 2003; 77: 258-272