Factor V Q506 Mutation (Activated Protein C Resistance) Associated with Reduced Intrapartum Blood Loss – a Possible Evolutionary Selection Mechanism

Pelle G. Lindqvist; Peter J. Svensson; Björn Dahlbäck; Karel Maršál

doi:10.1055/s-0037-1614222

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1998; 79(01): 69-73
DOI: 10.1055/s-0037-1614222

Review Article

Schattauer GmbH

Factor V Q⁵⁰⁶ Mutation (Activated Protein C Resistance) Associated with Reduced Intrapartum Blood Loss – a Possible Evolutionary Selection Mechanism

Authors

Pelle G. Lindqvist

¹The Department of Obstetrics and Gynaecology, University of Lund, University Hospital, Malmö, Sweden
Peter J. Svensson

²The Department of Clinical Chemistry and Coagulation Research, University of Lund, University Hospital, Malmö, Sweden
Björn Dahlbäck

²The Department of Clinical Chemistry and Coagulation Research, University of Lund, University Hospital, Malmö, Sweden
Karel Maršál

¹The Department of Obstetrics and Gynaecology, University of Lund, University Hospital, Malmö, Sweden

Abstract

Summary

Objectives. To ascertain whether relationship exists between the presence of APC resistance [a hypercoagulable state due to a mutation (R⁵⁰⁶Q) in the factor V gene] and the occurrence of pre-eclampsia (PE), intrauterine growth retardation (IUGR), and pregnancy bleeding complications. Design. A retrospective study. Subjects. A study group of 122 women with PE and/or IUGR during a recent pregnancy and a control group of 465 healthy pregnant women. Results. A significantly reduced risk of intrapartum bleeding complications in the APC-resistant subgroup as compared to the non-APC-resistant subgroup was suggested by reduced intrapartum blood loss, and pre- and postpartum haemoglobin measurements. The prevalence of APC resistance in the PE and IUGR subgroups did not differ significantly from that in the control group. Conclusion. The remarkably high prevalence of the potentially harmful factor V gene mutation in the general population may be the result of an evolutionary selection mechanism conferring such survival advantages as reduction in the risk of intrapartum bleeding on carriers of the FV:Q⁵⁰⁶ allele.

Full Text

References

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