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Thromb Haemost 1998; 80(06): 1029-1030
DOI: 10.1055/s-0037-1615408
Letters to the Editor
Schattauer GmbH

The 4G/5G Polymorphism of PAI-1 Promoter Gene and the Risk of Myocardial Infarction: A Meta-analysis

Authors

  • Licia Iacoviello

    1   Istituto di Ricerche Farmacologiche Mario Negri, Unit of Genetics of Vascular Risk Factors, “Angela Valenti” Laboratory of Thrombosis Pharmacology, Department of Vascular Medicine and Pharmacology
    3   Gaubius Laboratory, TNO-PG, Leiden, The Netherlands

  • Francesco Burzotta   *

    1   Istituto di Ricerche Farmacologiche Mario Negri, Unit of Genetics of Vascular Risk Factors, “Angela Valenti” Laboratory of Thrombosis Pharmacology, Department of Vascular Medicine and Pharmacology

  • Augusto Di Castelnuovo

    1   Istituto di Ricerche Farmacologiche Mario Negri, Unit of Genetics of Vascular Risk Factors, “Angela Valenti” Laboratory of Thrombosis Pharmacology, Department of Vascular Medicine and Pharmacology

  • Francesco Zito   **

    1   Istituto di Ricerche Farmacologiche Mario Negri, Unit of Genetics of Vascular Risk Factors, “Angela Valenti” Laboratory of Thrombosis Pharmacology, Department of Vascular Medicine and Pharmacology

  • Roberto Marchioli

    2   Laboratory of Clinical Epidemiology of Cardiovascular Disease, Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy

  • Maria Benedetta Donati

    1   Istituto di Ricerche Farmacologiche Mario Negri, Unit of Genetics of Vascular Risk Factors, “Angela Valenti” Laboratory of Thrombosis Pharmacology, Department of Vascular Medicine and Pharmacology
Weitere Informationen

Publikationsverlauf

Received 30. März 1998

Accepted after resubmission 12. August 1998

Publikationsdatum:
07. Dezember 2017 (online)

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* On leave of absence from the Institute of Cardiology, Catholic University, Rome, Italy


** Recipient of a Mario Negri Institute Fellowship “ALUMNI Association”


 

  • References

  • 1 Eriksson P, Kallin B, van’t Hooft FM, Bavenholm P, Hamsten A. Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.. Proc Natl Acad Sci USA 1995; 92: 1851-55.
    CrossrefPubMedSuche in Google Scholar
  • 2 Dawson SJ, Wiman B, Hamsten A, Green F, Humphries S, Henney AM. The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to inter-leukin 1 in HepG2 cells.. J Biol Chem 1993; 268: 10739-45.
    PubMedSuche in Google Scholar
  • 3 Ye S, Greeen FR, Scarabin PY, Nicaud V, Bara L, Dawson SJ, Humphries SE, Evans A, Luc G, Cambou JP, Arveiler D, Henney AM, Cambien F. The 4G/5G genetic polymorphism in the promoter of the plasminogen activator inhibitor 1 (PAI-1) gene is associated with differences in plasma PAI-1 activity but not with risk of myocardial infarction in the ECTIM study.. Thromb Haemost 1995; 74: 837-41.
    Thieme ConnectPubMedSuche in Google Scholar
  • 4 Mansfield MW, Stickland MH, Grant PJ. Plasminogen activator inhibitor 1 (PAI-1) promoter polymorphism and coronary artery disease in non-insulin dependent diabetes.. Thromb Haemost 1995; 74: 1032-34.
    Thieme ConnectPubMedSuche in Google Scholar
  • 5 Ossei-Gerning N, Mansfield MW, Stickland MH, Wilson IJ, Grant PJ. Plasminogen activator inhibitor-1 promoter 4G/5G genotype and plasma levels in relation to a history of myocardial infarction in patients characterized by coronary angiography.. Arterioscler Thromb Vasc Biol 1998; 17: 33-7.
    PubMedSuche in Google Scholar
  • 6 Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Miletich JP. Arterial and venous thrombosis is not associated with the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor gene in a large cohort of US men.. Circulation 1998; 95: 59-62.
    PubMedSuche in Google Scholar
  • 7 Burzotta F, Di Castelnuovo A, Amore C, D’Orazio A, Donati MB, Iacoviello L. 4G/5G polymorphism in the promoter region of the PAI-1 gene is not a risk factor for familial myocardial infarction: a case-control study in a sample of GISSI-2 patients.. Thromb Haemost 1998; 78: 1294-5.
    Thieme ConnectPubMedSuche in Google Scholar
  • 8 Colaizzo D, Margaglione M, Lirato C, Grandone E, Cappucci G, Fischetti A, Mancini FP, Pauciullo P, Di Minno G. Plasminogen activator inhibitor 1 4G/5G in subjects with a history of juvenile coronary heart disease.. Thromb Haemost 1998; Suppl: 97 (Abstract).
    PubMedSuche in Google Scholar
  • 9 van der Bom JC, Bots ML, Slagboom PE, Haverkate F, Meijer P, Kluft C, Grobbee DE. The risk of smoking is modified by the 4G allele of the PAI-1 gene.. Thromb Haemost 1998; Suppl: 579 (Abstract).
    Thieme ConnectPubMedSuche in Google Scholar
  • 10 Petitti DB. Meta-analysis, Decision Analysis and Cost-Effectiveness Analysis.. Oxford University Press 1994.
    PubMed
  • 11 Marchioli R, Marfisi RM, Carinci F, Tognoni G. Meta-analysis, clinical trials, and transferability of research results into practice. The case of cholesterol-lowering interventions in the secondary prevention of coronary artery disease.. Arch Intern Med 1996; 156: 1158-72.
    CrossrefPubMedSuche in Google Scholar