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Thromb Haemost 1994; 71(05): 593-595
DOI: 10.1055/s-0038-1642488
Review Article
Schattauer GmbH Stuttgart

Fibrinogen Plasma Levels as a Marker of Thrombin Activation: New Insights on the Role of Fibrinogen as a Cardiovascular Risk Factor

Authors

  • Antonio Ceriello

    The Department of Clinic and Experimental Pathology, Chair of Internal Medicine and Chair of Clinic Pathology, University of Udine, Udine, Italy

  • Mario Pirisi

    The Department of Clinic and Experimental Pathology, Chair of Internal Medicine and Chair of Clinic Pathology, University of Udine, Udine, Italy

  • Roberta Giacomello

    The Department of Clinic and Experimental Pathology, Chair of Internal Medicine and Chair of Clinic Pathology, University of Udine, Udine, Italy

  • Giuliana Stel

    The Department of Clinic and Experimental Pathology, Chair of Internal Medicine and Chair of Clinic Pathology, University of Udine, Udine, Italy

  • Edmondo Falleti

    The Department of Clinic and Experimental Pathology, Chair of Internal Medicine and Chair of Clinic Pathology, University of Udine, Udine, Italy

  • Enrico Motz

    The Department of Clinic and Experimental Pathology, Chair of Internal Medicine and Chair of Clinic Pathology, University of Udine, Udine, Italy

  • Sebastiano Lizzio

    The Department of Clinic and Experimental Pathology, Chair of Internal Medicine and Chair of Clinic Pathology, University of Udine, Udine, Italy

  • Fabio Gonano

    The Department of Clinic and Experimental Pathology, Chair of Internal Medicine and Chair of Clinic Pathology, University of Udine, Udine, Italy

  • Ettore Bartoli

    The Department of Clinic and Experimental Pathology, Chair of Internal Medicine and Chair of Clinic Pathology, University of Udine, Udine, Italy
Weitere Informationen

Publikationsverlauf

Received 02. September 1993

Accepted after revision 31. Januar 1994

Publikationsdatum:
06. Juli 2018 (online)

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Summary

Fibrinogen has recently emerged as a major risk factor for athero- thrombosis. However, the pathophysiologic mechanism linking high fibrinogen concentration to cardiovascular disease is unclear.

In this study 136 subjects (75 males, 61 females, age 51.7 ± 14.4 years, mean ± standard deviation, range 17-82) were tested for total and HDL-cholesterol, total triglycerides, apolipoprotein AI, apolipo- protein B, fibrinogen, prothrombin fragment and D-dimer. Moreover, 5 subjects who had hyperfibrinogenemia (range 450 to 950 mg/dl) for at least 6 months by repeated measurements, were treated with a short 7-day course of heparin 12,500 U/day subcutaneously. The effect of heparin on all the above mentioned parameters was observed at the end of treatment and after 7 days of wash-out. Simple regression analysis detected a positive correlation between fibrinogen and age, prothrombin fragment and D-dimer, and a negative correlation between fibrinogen and HDL-cholesterol and apolipoprotein AI. A direct correlation between age and both prothrombin fragment and D-dimer was also demonstrated. Multivariate analysis showed a persistent correlation between fibrinogen and prothrombin fragment, D-dimer and age, that was not influenced by sex, smoking habit and body mass index. In the 5 hyperfibrinogenemic subjects, heparin administration significantly reduced fibrinogen (625.4 ± 211.1 vs 455.2 ± 112.3 mg/dl, p <0.03), prothrombin fragment (0.97 ± 0.1 vs 0.63 ± 0.2 nM, p <0.002) and D-dimer (336 ± 101.8 vs 275.2 ± 78.5 ng/ml, p <0.03). All these parameters returned to baseline after 7 days of wash-out (fibrinogen 632.5 ± 198.2 mg/dl, prothrombin fragment 0.96 ± 0.2 nM, D-dimer 325.8 ±98.65 ng/ml).

These data indicate that fibrinogen plasma levels are strongly correlated to parameters of thrombin activation in plasma and suggest that high fibrinogen plasma levels might be a risk marker for cardiovascular disease because expression of an existing thrombophilia.