The Plasminogen Activator of the Arterial Wall

L Donner; P Klener; Z Roth

doi:10.1055/s-0038-1649252

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1977; 37(03): 436-443
DOI: 10.1055/s-0038-1649252

Original Article

Schattauer GmbH

The Plasminogen Activator of the Arterial Wall

L Donner

¹Department of Medicine, Charles University, Division of Haematology and the Department of Mathematical Statistics and Programming, Institute of Hygiene and Epidemiology, Prague, Czechoslovakia

,

P Klener

¹Department of Medicine, Charles University, Division of Haematology and the Department of Mathematical Statistics and Programming, Institute of Hygiene and Epidemiology, Prague, Czechoslovakia

,

Z Roth

¹Department of Medicine, Charles University, Division of Haematology and the Department of Mathematical Statistics and Programming, Institute of Hygiene and Epidemiology, Prague, Czechoslovakia

› Institutsangaben

Abstract

als PDF herunterladen

Summary

The plasminogen activator in 645 specimens of various human arteries – thoracic, abdominal aorta, carotic, pulmonary, renal, basilar, coronary – was studied using Todd’s histochemi-cal method. 92 cadavers were used, 1–18 hours post mortem from subjects aged from 272 days to 83 years. 45 specimens of pulmonary, renal and splenic arteries were obtained during surgery.

The greatest fibrinolytic activity was within the adventitia. Intima occasionally showed very little fibrinolytic activity, or none at all.

No statistically significant differences in plasminogen activator activity were found between the various arteries examined.

A statistically significant increase in fibrinolysis in adventitia of atherosclerotic arteries was established. No correlation was found between the fibrinolytic activity of the arteries and their alkaline phosphatase content.

Some properties of the plasminogen activator of the arterial vessel wall were evaluated. Influence of storage, inactivation with epsilonaminocaproic acid and extracted with potassium thiocyanate was studied.

PDF (6395 kb)

Referenzen

References
1 Albrechtsen O. K. Fibrinolytic activity in the organism. Acta Physiologica Scandinavica 1959; 47 suppl. 165
2 Astrup T, Albrechtsen O. K. Estimation of the plasminogen activator and the trypsin inhibitor in animal and human tissues. Scandinavian Journal of Clinical and Laboratory Investigation 1957; 9: 233
3 Astrup T, Coccheri S. Thromboplastic and fibrinolytic activity of the arteriosclerotic human aorta. Nature (London) 1962; 193: 182
4 Constantini R, Hilbe G, Spötl F, Holzknecht F. The plasminogen activator content of the arterial wall in occlusive arterial diseases. Thrombosis et Diathesis Haemorrhagica (Stuttgart) 1972; 27: 649
5 Constantini R, Spötl F, Holzknecht F, Herbst M, Braunsteiner H. On the plasminogen activator content of forearm-veins in patients with primary “carbohydrate-induced” hypertriglyceridemia. Coagulation 1969; 2: 361
6 Chrobák L, Bartoš VI, Brzek VI, Hnízdová D. Coagulation properties of human thoracic duct lymph. American Journal of Medical Service 1967; 253: 100
7 Jellinek H. Arterial Lesions and Arteriosclerosis. Akadémiai Kiadó; Budapest: 136 1974
8 Kwaan H. C, Astrup T. Fibrinolytic activity of reparative connective tissue. Journal of Pathology and Bacteriology 1964; 84: 409
9 Lieberman J. F, Kellog F. Fibrinolytic activity of arterial tissues. Circulation Research 1961; 9: 515
10 Lojda Z. Enzymhistochemische Methoden. Springer, Berlin, Heidelberg; New York.: 1976
11 Nordhoek Hegt V, Brakman P. Histochemical study of an inhibitor of fibrinolysis in the human arterial wall. Nature (London) 1974; 248: 75
12 Onoyama K, Tanaka K. Fibrinolytic activity of the arterial wall. Thrombosis et Diathesis Haemorrhagica 1969; 21: 1
13 Pandolfi M, Nilsson I. M, Robertson B, Isacson S. Fibrinolytic activity of human veins. Lancet 1967; 2: 127
14 Pandolfi M, Robertson B, Isacson S, Nilsson I. M. Fibrinolytic activity of human veins in arms and legs. Thrombosis et Diathesis Haemorrhagica 1968; 20: 247
15 Risberg B. Fibrinolysis in the lung. Acta chirurgica scandinavia Suppl 1975; 458
16 Sandberg H, Rezai M, Bellet S, Feinberg J, Moliver S. Gelbert Fibrinolytic activity of human tissues from adult and infant cadavers. Journal of Laboratory and Clinical Medicine 1964; 64: 99
17 Todd A. S. Fibrinolysis autographs. Nature (London) 1958; 181: 495
18 Todd A. S. The histological localisation of plasma activator. Journal of Pathology and Bacteriology 1959; 78: 281
19 Todd A. S. Tissue activator of plasminogen and thrombosis. In: W. Walker (Ed.) Thrombosis and Anticoagulant Therapy; Livingstone, Edinburgh: 21
20 Todd A. S. Localisation of fibrinolytic activity in tissues. British Medical Bulletin 1964; 210
21 Todd A. S. Blood vessel wall and fibrinolytic activity. In Johnson S. A, Guest M. M. (Eds.) Dynamics of Thrombus formation and Dissolution. Lippincot. Philadelphia: 321 1964
22 Todd A. S, Hargraves L. N. Mc. F. Identification of plasminogen activator. In Davidson J. F, Samama M. M, Desnoyer P. C. (Eds.)Progress in Chemical Fibrinolysis and Thrombosis. Raven Press; New York: 1975: 217
23 Warren B. A. Fibrinolytic properties of vascular endothelium. British Journal of Experimental Pathology 1963; 44: 365