Transport Processes in Fibrinolysis and Fibrinolytic Therapy

Aleš Blinc; Charles W Francis

doi:10.1055/s-0038-1650608

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1996; 76(04): 481-491
DOI: 10.1055/s-0038-1650608

Review Article

Schattauer GmbH Stuttgart

Transport Processes in Fibrinolysis and Fibrinolytic Therapy

Authors

Aleš Blinc

¹The University of Ljubljana Clinical Center, Trnovo Hospital of Internal Medicine, Ljubljana, Slovenia, USA
Charles W Francis

²The Hematology Unit, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, New York, USA

Abstract

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References

References
1 Tanaka T. Gels. Sci Am 1981; 244: 124-138
2 Me Gregor R. Diffusion and sorption in fibers and films. Volume 1, Chapter 2: The Brownian motion and the continuum approximation Academic Press, London and New York 1974: 12-18
3 Milnor WR. Capillaries and lymphatic vessels. In: Medical Physiology, Vol. II, 13th ed Mountcastle VB. ed. The C. V. Mosby Co.; St Louis: 1974: 984-992
4 Me Gregor R. Diffusion and sorption in fibers and films. Volume 1, Chapter 15: Some mechanistic considerations Academic Press; London and New York: 1974: 193-220
5 Okada M, Blombäck B. Factors influencing fibrin gel structure studied by flow measurement. Ann NY Acad Sci 1983; 408: 233-253
6 Blinc A, Keber D, Lahajnar G, Stegnar M, Zidansek A, Demsar F. Lysing patterns of retracted blood clots with diffusion or bulk flow transport of plasma with urokinase into clots - a magnetic resonance imaging study in vitro. Thromb Haemost 1992; 68: 667-671
7 Mathur-De Vre R. The NMR studies of water in biologycal systems. Progr Biophys Molec Biol 1979; 35: 103-134
8 Blinc A, Lahajnar G, Blinc R, Zidansek A, Sepe A. Proton NMR study of the state of water in fibrin gels, plasma, and blood clots. Magn Reson Med 1990; 14: 105-122
9 Brenner SH, Gaydos LJ. The constrained Brownian movement of spherical particles in cylindrical pores of comparable radius: models of the diffusive and convective transport of solute molecules in membranes and porous media. J Colloid Interface Sci 1977; 58: 312-355
10 Phillips RJ, Deen WM, Brady JF. Hindered transport in fibrous membranes and gels: effect of solute size and fiber configuration. J Colloid Interface Sci 1990; 139: 363-373
11 Carr ME, Hardin CL. Fibrin has larger pores when formed in the presence of erythrocytes. Am J Physiol 1987; 253: H1069-H1073
12 Carr ME. Fibrin formed in plasma is composed of fibers more massive than those formed from purified fibrinogen. Thromb Haemost 1988; 59: 535-539
13 Stewart UA, Bradley MS, Johnson CS, Gabriel DA. Transport of probe molecules through fibrin gels as observed by means of holographic relaxation methods. Biopolymers 1988; 27: 173-185
14 Matveyev MY, Domogatsky SP. Penetration of macromolecules into contracted blood clot. Biophys J 1992; 63: 862-863
15 Lucas MA, Fretto LJ, McKee PA. The binding of human plasminogen to fibrin and fibrinogen. J Biol Chem 1983; 258: 4249-4256
16 Whitaker AN, Rowe EA, Masci PP, Joe F, Gaffney PJ. The binding of glu-and lys-plasminogens to fibrin and their subsequent effects on fibrinolysis. Thromb Res 1980; 19: 381-391
17 Suenson E, Thorsen S. Secondary-site binding of Glu-plasmin, Lys-plas-min and miniplasmin to fibrin. Biochem J 1981; 197: 619-628
18 Hussain SS, Hasan AAK, Budzynski AZ. Differences between binding of one-chain and two-chain tissue plasminogen activator to non-cross-linked and cross-linked fibrin clots. Blood 1989; 74: 999-1006
19 Diamond S, Anand S. Inner clot diffusion and permeation during fibrinolysis. Biophys J 1993; 65: 2622-2643
20 Blackmore CC, Francis CW, Bryant RG, Brenner B, Marder VJ. Magnetic resonance imaging of blood and clots in vitro. Invest Radiol 1990; 25: 1316-1324
21 Sakharov DV, Rijken DC. Superficial accumulation of plasminogen during plasma clot lysis. Circulation 1995; 92: 1883-1890
22 Sakharov DV, Nagelkerke JF, Rijken DC. Rearrangements of the fibrin network and spatial distribution of fibrinolytic components during plasma clot lysis. J Biol Chem 1996; 271: 2133-2138
23 Hisano S. Immunofluorescence study on thrombolysis with special reference to patterns of distribution and the contents of fibrin, plasminogen, alpha-2-macroglobulin and urokinase in artificial thrombi. Thromb Haemost 1979; 39: 53-60
24 Krause J, Deutsch H. Localisation of fluorescence-labelled recombinant tissue-type plasminogen activator (rt-PA) on thrombi in vitro. Fibrinolysis 1989; 3: 35-39
25 Senf L. In vitro Messungen der Fibrinolyse durch Streptokinase. Folia Haematol, Leipzig 1981; 108: 819-821
26 Blombäck B, Okada M. Fibrin gel structure and clotting time. Thromb Res 1982; 25: 51-70
27 Carr ME, Shen LL, Hermans J. Mass-length ratio of fibrin fibers from gel permeation and light scattering. Biopolymers 1977; 16: 1-15
28 Shah GA, Nair CH, Dhall DP. Comparison of fibrin networks in plasma and fibrinogen solution. Thromb Res 1987; 45: 257-264
29 Blinc A, Planinsic G, Keber D, Jarh O, Lahajnar G, Zidansek A, Demsar F. Dependence of blood clot lysis on the mode of transport of urokinase into the clot a magnetic resonance maging study in vitro. Thromb Haemost 1991; 65: 549-552
30 Blinc A, Kennedy SD, Bryant RG, Marder VJ, Francis CW. Flow through blood clots determines the rate and pattern of fibrinolysis. Thromb Haemost 1994; 71: 230-235
31 Nair CH, Dhall DP. Studies on fibrin network structure: the effect of some plasma proteins. Thromb Res 1991; 61: 315-325
32 Nair CH, Azhar A, Dhall DP. Studies on fibrin network structure in human plasma. Part one: Methods for clinical application. Thromb Res 1991; 64: 455-476
33 Boyer MH, Shainoff JR, Ratnoff OD. Acceleration of fibrin polymerization by calcium ions. Blood 1972; 39: 382-387
34 Marguerie G, Benabid Y, Suscillon M. The binding of calcium to fibrinogen: influence on the clotting process. Biochim Biophys Acta 1979; 579: 134-141
35 Shen L, Hermans J, McDonagh J, McDonagh RP, Carr M. Effects of calcium ion and covalent cross-linking on formation and elasticity of fibrin gels. Thromb Res 1979; 6: 255-265
36 Carr ME, Gabriel DA. Dextran-induced changes in fibrin fiber size and density based on wavelength dependence of gel turbidity. Macromolecules 1980; 13: 1473-1477
37 Carr ME, Gabriel DA. The effect of dextran 70 on the structure of plasma-derived fibrin gels. J Lab Clin Med 1980; 96: 985-993
38 Carr ME, Gabriel DA, McDonagh J. Influence of calcium on the structure of reptilase and thrombin derived fibrin gels. Biochem J 1986; 239: 513-516
39 Carr ME. The effect of hydroxyethyl starch on the structure of thrombin and reptilase induced fibrin gels. J Lab Clin Med 1986; 108: 556-561
40 Carr ME, White GC, Gabriel DA. Platelet factor 4 causes increased fibrin gel fiber size. Thromb Res 1987; 45: 539-543
41 Carr ME, Gabriel DA, Herion JC, Roberts HR. Granulocyte lysosomal cationic protein alters fibrin assembly: a possible mechanism for granulocyte control of clot structure. J Lab Clin Med 1986; 107: 199-203
42 Carr ME. Turbidimetric evaluation of albumin’s impact on the structure of thrombin mediated fibrin gels. Haemostasis 1987; 17: 189-194
43 Torbet J. Fibrin assembly in human plasma and fibrinogen/albumin mixtures. Biochemistry 1986; 25: 5309-5314
44 Leung LLK. Interaction of histidine rich glycoprotein with fibrinogen and fibrin. J Clin Invest 1986; 77: 1305-1311
45 Wilf J, Gladner JA, Minton AP. Acceleration of fibrin gel formation by unrelated proteins. Thromb Res 1985; 37: 681-688
46 Bale MD, Westrick LG, Mosher DF. Incorporation of thrombospondin into fibrin clots. J Biol Chem 1985; 260: 7502-7508
47 Gabriely DA, Smith LA, Folds JD, Davis L, Cancelosi SE. The influence of immunoglobulin (IgG) on the assembly of fibrin gels. J Lab Clin Med 1983; 101: 545-552
48 Galanakis DK, Lane BP, Simon SR. Albumin modulates lateral assembly of fibrin polymers: evidence of enhanced fine fibril formation and of unique synergism with fibrinogen. Biochemistry 1987; 26: 2389-2400
49 Dhall TZ, Shah GA, Ferguson IA, Dhall DP. Fibrin network structure: modification by platelets. Thromb Haemost 1983; 49: 42-46
50 Carr ME, Gabriel DA, McDonagh J. Influence of factor XIII and fibronec-tin on fiber size in thrombin-induced fibrin gels. J Lab Clin Med 1987; 110: 747-752
51 Freiman DG. The structure of thrombi. In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 2nd ed Colman RW, Hirsh J, Marder VJ, Salzman EW. eds. J. B. Lippincott Company; Philadelphia: 1987: 1123-1135
52 Madras PN, Morton WA, Petschek HE. Dynamics of thrombus formation. Fed Proceedings 1971; 30: 1665-1676
53 Blombäck B, Hessel B, Hogg D, Therkildsen L. A two step fibrinogen-fibrin transition in blood coagulation. Nature 1978; 257: 501-505
54 Moschos CB, Oldewutrel HA, Haider B, Regan TJ. Effect of coronary thrombus age on fibrinogen uptake. Circulation 1976; 54: 653-656
55 Sabovic M, Lijnen HR, Keber D, Collen D. Effect of retraction on the lysis of human clots with fibrin-specific and non-fibrin specific plasminogen activators. Thromb Haemost 1989; 62: 1083-1087
56 Sabovic M, Lijnen HR, Keber D, Collen D. Correlation between progressive adsorption of plasminogen to blood clots and their sensitivity to lysis. Thromb Haemost 1990; 64: 450-454
57 Sabovic M, Keber D. In vitro synergism between t-PA and scu-PA depends on clot retraction. Fibrinolysis 1995; 9: 101-105
58 Sobel BE, Nachowiak DA, Fry ETA, Bergmann SR, Torr SR. Paradoxical attenuation of fibrinolysis attributable to “plasminogen steal” and its implications for coronary thrombolysis. Coronary Artery Dis 1990; 1: 111-119
59 Onundarson PT, Francis CW, Marder VJ. Depletion of plasminogen in vitro during thrombolytic therapy limits fibrinolytic potential. J Lab Clin Med 1992; 120: 120-128
60 Onundarson PT, Francis CW, Marder VJ. Plasminogen depletion during streptokinase treatment or two-chain urokinase incubation correlates with decreased clot lysability ex vivo and in vitro. Thromb Haemost 1993; 70: 998-1004
61 Nishino N, Kakkar VV, Scully MR. Influence of intrinsic and extrinsic plasminogen upon the lysis of thrombi in vitro. Thromb Haemost 1991; 66: 672-677
62 Harpel PC, Chang TS, Verderber E. Tissue plasminogen activator and urokinase mediate the binding of glu-plasminogen to plasma fibrin: evidence for new binding sites in plasmin-degraded fibrin. J Biol Chem 1985; 260: 4432-4440
63 Gurewich V. The sequential, complementary and synergistic activation of fibrin-bound plasminogen by tissue plasminogen activator and pro-urokinase. Fibrinolysis 1989; 3: 59-66
64 Wu JH, Siddiqui K, Diamond SL. Transport phenomena and clot dissolving therapy: an experimental investigation of diffusion-controlled and permeation-enhanced fibrinolysis. Thromb Haemost 1994; 72: 105-112
65 Senf L. In vitro Untersuchungen und modellrechnungen zur Kinetik der Fibrinolyse durch Streptokinase. Folia Haematol, Leipzig 1979; 106: 899-907
66 Zidansek A, Blinc A, Lahajnar G, Keber D, Blinc R. Finger-like lysing patterns of blood clots. Biophys J 1995; 69: 803-809
67 Nishino N, Scully MF, Rampling MW, Kakkar VV. Properties of thrombolytic agents in vitro using a perfusion circuit attaining shear stress at physiological level. Thromb Haemost 1990; 64: 550-555
68 Senf L. A special case of diffusion with a moving boundary considered as a propagating wave. Int J Heat Mass Transfer 1983; 26: 301-302
69 Zidansek A, Blinc A. The influence of transport parameters and enzyme kinetics of the fibrinolytic system on thrombolysis: mathematical modelling of two idealised cases. Thromb Haemost 1991; 65: 553-559
70 Anand S, Wu JH, Diamond SL. Enzyme mediated proteolysis of fibrous bioplymers: dissolution front movement in fibrin or collagen under conditions of diffusion or convective transport. Biotechnol Bioeng 1995; 48: 89-107
71 Senf L. Zur Diffusion in Fibrin bei gleichzeitiger Fibrinolyse. Folia Haematol Leipzig 1981; 108: 439-446
72 Zidansek A, Blinc A, Lahajnar G, Keber D, Blinc R. Lysing patterns of blood clots: a nuclear magnetic resonance imaging study in vitro and mathematical modelling of the lysing pattern kinetics. J Mol Struct 1993; 294: 283-286
73 Bookstein JJ, Saldinger E. Accelerated thrombolysis - in vitro evaluation of agents and methods of administration. Invest Radiol 1985; 20: 731-735
74 Valji K, Bookstein JJ. Fibrinolysis with intrathrombic injection of urokinase and tissue-type plasminogen activator - results in a new model of subacute venous thrombosis. Invest Radiol 1987; 22: 23-27
75 Kandarpa K, Drinker PA, Singer SJ, Caramore D. Forceful pulsatile local infusion of enzyme accelerates thrombolysis: in vivo evaluation of a new delivery system. Radiology 1988; 168: 739-744
76 Valji K, Roberts AC, Davis GB, Bookstein JJ. Pulsed-spray thrombolysis of arterial and bypass graft occlusions. A J R 1991; 156: 617-621
77 Bildsoe MC, Moradian GP, Hunter DW, Castaneda-Zuniga WR, Amplatz K. Mechanical clot dissolution: new concept. Radiology 1989; 171: 231-233
78 Sullivan KL, Gardiner GA, Shapiro MJ, Bonn J, Levin DC. Acceleration of thrombolysis with a high dose transthrombus bolus technique. Radiology 1989; 173: 805-808
79 Jang IK, Gold H, Ziskind AA, Fallon JT, Holt RE, Leinbach RC, May JW, Collen D. Differential sensitivity of erythrocyte-rich and platelet-rich arterial thrombi to lysis with recombinant tissue-type plasminogen activator -a possible explanation for resistance to coronary thrombolysis. Circulation 1989; 79: 920-928
80 Prewitt RM, Gu S, Garber PJ, Ducas J. Marked systemic hypotension depresses coronary thrombolysis induced by intracoronary administration of recombinant tissue-type plasminogen activator. J Am Coll cardiol 1992; 20: 1626-1633
81 Prewitt RM, Gu SA, Greenberg D, Chan SM, Schick U, LaPointe H, Ducas J. Effects of flow on recombinant tissue plasminogen activator-induced pulmonary thrombolysis. J Appl Physiol 1991; 71: 1441-1446
82 Francis CW, Onundarson PT, Carstensen EL, Blinc A, Meltzer RS, Schwarz K, Marder VJ. Enhancement of fibrinolysis in vitro by ultrasound. J Clin Invest 1992; 90: 2063-2068
83 Blinc A, Francis CW, Trudnowski JL, Carstensen EL. Characterization of ultrasound-potentiated fibrinoysis in vitro. Blood 1993; 81: 2636-2643
84 Lauer CG, Burge R, Tang DB, Bass BG, Gomez ER. Alving BM: Effect of ultrasound on tissue-type plasminogen activator induced thrombolysis. Circulation 1991; 84: 1257-1264
85 Kudo S. Thrombolysis with ultrasound effect. Tokyo Jikeikai Med J 1989; 104: 1005-1012
86 Kashyap A, Blinc A, Marder VJ, Penney DP, Francis CW. Acceleration of fibrinolysis by ultrasound in a rabbit ear model of small vessel injury. Thromb Res 1994; 76: 475-485
87 Francis CW, Blinc A, Lee S, Cox C. Ultrasound accelerates transport of recombinant tissue plasminogen activator into clots. Ultrasound Med Biol 1995; 21: 419-424
88 Siddiqi F, Blinc A, Braaten J, Francis CW. Ultrasound increases flow through fibrin gels. Thromb Haemost 1995; 73: 495-498
89 Braaten JV, Siddiqi F, Francis CW. Ultrasound reversibly alters fluid permeation and fiber density in fibrin gels. Thromb Haemost 1995; 73: 1226 (abst).
90 Francis CW, Markham Jr RE, Barlow GH, Florack TM, Dobrzynski D, Marder VJ. Thrombin activity of fibrin thrombi and soluble plasmic derivatives. J Lab Clin Med 1983; 102: 220-230
91 Farstad IN, Dielsen DWT, Ruyter R, Godal HC. Thrombin activity in pulmonary emboli obtained at autopsy. Thromb Res 1990; 59: 879-882
92 Martin M. Thrombolytic therapy in arterial thromboembolism. Prog Cardiovas Dis 1979; 21: 351-374
93 Amery A, Deloof W, Vermylen J, Verstraete M. Outcome of recent thromboembolic occlusions of limb arteries treated with streptokinase. Br Med J 1970; 4: 639-644
94 Hume M, Gurewich V, Thomas DP, Dealy Jr JB. Streptokinase for chronic arterial occlusive disease. Arch Surg 1970; 101: 653-657
95 Verstraete M, Vermylen J, Donati MB. The effect of streptokinase infusion on chronic arterial occlusions and stenosis. Ann Int Med 1971; 74: 377-382
96 Duetch E, Ehringer H. Thrombolytic therapy in chronic arterial occlusions. J Clin Path 1972; 25: 644 (abst).
97 McNicol GP, Reid W, Bain WH, Douglas AS. Treatment of peripheral arterial occlusion by streptokinase perfusion. Br Med J 1963; 1: 1508-1512
98 Dotter CT, Rosch J, Seaman AJ. Selective clot lysis with low-dose streptokinase. Radiol 1974; 111: 31-37
99 Hess H, Ingrisch H, Mietaschk A, Rath H. Local low-dose thrombolytic therapy of peripheral arterial occlusions. New Engl J Med 1982; 307: 1627-1630
100 Katzen BT, van Breda A. Low dose streptokinase in the treatment of arterial occlusions. AJR 1981; 136: 1171-1178
101 Totty WC, Gilula LA, McClennan BL, Ahmed P, Sherman L. Low-dose intravascular fibrinolytic therapy. Radiology 1982; 143: 59-69
102 Hargrove WC, Berkowitz HD, Freiman DB, McLean G, Ring RJ, Roberts B. Recanalization of totally occluded femoropopliteal vein grafts with low-dose streptokinase infusion. Surgery 1982; 92: 890-895
103 Becker GJ, Rabe RE, Richmond BD, Holden RW, Yune HY, Dilley RS, Bang NU, Glover JL, Klatte EC. Low-dose fibrinolytic therapy. Results and new concepts. Radiology 1983; 148: 663-670
104 van Breda A, Robison JC, Feldman L, Waltman AC, Brewster DC, Abbott WM, Athanasoulis CA. Local thrombolysis in the treatment of arterial graft occlusions. J Vase Surg 1984; 1: 103-112
105 Graor RA, Risius B, Denny KM, Young JR, Beven EG, Hertzer NR, Fuschhaupt III WF, O’Hara PJ, Geisinger MA, Zelch MG. Local thrombolysis in the treatment of thrombosed arteries, bypass grafts, and arteriovenous fistulas. J Vase Surg 1985; 1: 406-414
106 Gardiner Jr GA, Koltun W, Kandarpa K, Whittemore A, Meyerovitz MF, Bettmann MA, Levin DC, Harrington DP. Thrombolysis of occluded femoropopliteal grafts. AJR 1986; 147: 621-626
107 LeBolt SA, Tisnado J, Cho S-R. Treatment of peripheral arterial obstruction with streptokinase: Results in arterial vs graft occlusions. AJR 1988; 151: 589-592
108 Seabrook GR, Mewissen MW, Schmitt DD, Reifsnyder T, Bandyk DF, Lipchik EO, Towne JB. Percutaneous intraarterial thrombolysis in the treatment of thrombosis of lower extremity arterial reconstructions. J Vase Surg 1991; 13: 646-651
109 McNamara RO, Bomberger RA, Merchant RF. Intra-arterial urokinase as the initial therapy for acutely ischemic lower limbs. Circulation 1991; (Suppl. 83) I-106-I-119
110 Berridge DC, Gregson RHS, Hopkinson BR, Makin GS. Randomized trial of intra-arterial recombinant tissue plasminogen activator, intravenous recombinant tissue plasminogen activator and intra-arterial streptokinase in peripheral arterial thrombolysis. Br J Surg 1991; 78: 988-995
111 Ouriel K, Shortell CK, DeWeese JA, Green RM, Francis CW, Azodo MVU, Gutierrez OH, Manzione JV, Cox C, Marder VJ. A comparison of thrombolytic therapy with operative revascularization in the initial treatment of acute peripheral arterial ischemia. J Vase Surg 1994; 19: 1021-1030
112 The STILE Investigators. Results of a prospective randomized trial evaluating surgery versus thrombolysis for ischemia of the lower extremity. The STILE Trial. Ann Surg 1994; 220: 251-268
113 Sullivan KL, Gardiner Jr GA, Shapiro MJ, Bonn J, Levin DC. Acceleration of thrombolysis with a high-dose transthrombus bolus technique. Radiology 1989; 173: 805-808
114 Meyerovitz MF, Goldhaber SZ, Reagan K, Polak JF, Kandarpa K, Grassi CJ, Donovan BC, Bettmann MA, Harrington DP. Recombinant tissue-type plasminogen activator versus urokinase in peripheral arterial and graft occlusions: A randomized trial. Radiology 1990; 175: 75-78
115 Cragg AH, Smith TP, Corson JD, Nakagawa N, Castaneda F, Kresowik TF, Sharp WJ, Shamma A, Berbaum KS. Two urokinase dose regimens in native arterial and graft occlusions: Initial results of a prospective, randomized clinical trial. Radiology 1991; 178: 681-686
116 Hicks ME, Picus D, Darcy MD, Kleinhofer MA. Multilevel infusion catheter for use with thrombolytic agents. JVIR 1991; 1: 73-75
117 Mewissen MW, Minor PL, Beyer GA, Lipchick EO. Symptomatic native arterial occlusions: early experience with “over-the-wire” thrombolysis. JVIR 1990; 1: 43-47
118 McNamara TO. The use of lytic therapy with endovascular “repair” for the failed infrainguinal graft. Sem Vase Surg 1990; 3: 56-65
119 Valji K, Roberts AC, David GB, Bookstein JJ. Pulsed-spray thrombolysis of arterial and bypass graft occlusions. AJR 1991; 156: 617-621
120 Kandarpa K, Chopra PS, Aruny JE, Polak JF, Donaldson MC, Whittemore AD, Mannick JA, Goldhaber SZ, Meyerovitz MF. Intraarterial thrombolysis of lower extremity occlusions: Prospective, randomized comparison of forced periodic infusion and conventional slow continuous infusion. Radiology 1993; 188: 861-867
121 McNamara TO, Fischer JR. Thrombolysis of peripheral arterial and graft occlusions: Improved results using high-dose urokinase. AJR 1985; 144: 769-775
122 Ouriel K, Shortell CK, Azodo MVU, Guilterrez OH, Marder VJ. Acute peripheral arterial occlusion: Predictors of success in catheter-directed thrombolytic therapy. Radiology 1994; 193: 561-566
123 Dunn BP, Livingstone WR, Macdougall AI, Rennie JB, Watt DA. Declotting Scribner shunts. Lancet 1969; 2: 328
124 Schilling JJ, Eiser AR, Slifkin RF, Whitney JT, Neff MS. The role of thrombolysis in hemodialysis access occlusion. Am J Kidney Dis 1987; 10: 92-97
125 Rodkin RS, Bookstein JJ, Heeney DJ, Davis GB. Streptokinase and transluminal angioplasty in the treatment of acutely thrombosed hemodialysis access fistulas. Radiology 1983; 149: 425-428
126 Young AT, Hunter DW, Castaneda Zuniga WR, So SK, Mercado S, Car-della JF, Amplatz K. Thrombosed synthetic hemodialysis access fistulae: failure of fibrinolytic therapy. Radiology 1985; 154: 639-642
127 Valji K. Transcatheter treatment of thrombosed hemodialysis access grafts. AJR 1995; 164: 823-829
128 Valji K, Bookstein JJ, Roberts AC, Oglevie SB, Pittman C, O’Neill MP. Pulse-spray pharmacomechanical thrombolysis of thrombosed hemodialysis access grafts: Long-term experience and comparison of original and current techniques. AJR 1995; 164: 1495-1500
129 Davis GB, Dowd CF, Bookstein JJ, Maroney TP, Lang EV, Halasz N. Thrombosed dialysis grafts: Efficacy of intrathrombic deposition of concentrated urokinase, clot maceration, and angioplasty. AJR 1987; 149: 177-181
130 Sands JJ, Patel S, Plaviak D, Miranda CL. Pharmacomechanical thrombolysis with urokinase for treatment of thrombosed hemodialysis access grafts: a comparison with surgical thrombectomy. ASAIO J 1994; 40: M866-M888
131 Fletcher AP, Alkjaersig N, Smymiotis FE. The treatment of patients suffering from early myocardial infarction with massive and prolonged streptokinase therapy. Trans Assoc Am Physicians 1958; 71: 287
132 Boucek RJ, Murphy Jr WP. Segmental perfusion of the coronary arteries with fibrinolysin in man following a myocardial infarction. Am J Cardiol 1960; 6: 525
133 Marder VJ, Francis CW. Thrombolytic therapy for acute transmural myocardial infarction. Intracoronary versus intravenous. Am J Med 1984; 77: 921-928
134 European Cooperative Study Group for Streptokinase Treatment in Acute Myocardial Infarction Streptokinase in acute myocardial infarction. New Engl J Med 1979; 301: 797-802
135 DeWood MA, Spores J, Notske R, Mouser LT, Burroughs R, Golden MS, Lang HT. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. New Engl J Med 1980; 303: 897-901
136 Rentrop KP, Blanke H, Karsch KR, Wiegand V, Kostering H, Oster H, Leitz K. Acute myocardial infarction: Intracoronary application of nitroglycerin and streptokinase in combination with transluminal recanalization. Clin Cardiol 1979; 1: 354-363
137 Rentrop P, Blanke H, Karsch KR, Kaiser H, Kostering H, Leitz K. Selective intracoronary thrombolysis in acute myocardial infarction and unstable angina pectoris. Circulation 1981; 63: 307-316
138 Rentrop KP. Thrombolytic therapy in patients with acute myocardial infarction. Circulation 1985; 71: 627-631
139 Rogers WJ, Mantle JA, Hood Jr WP, Baxley WA, Whitlow PL, Reeves RC, Soto B. Prospective randomized trial of intravenous and intracoronary SK in AMI. Circulation 1983; 68: 1051-1061
140 Alderman EL, Jutzy KR, Berte LE, Miller RG, Friedman JP, Creger WP, Eliastam M. Randomized comparison of intravenous versus intracoronary SK or MI. Am J Cardiol 1984; 54: 14-19
141 Taylor GJ, Mikell FL, Moses HW, Dove JT, Batchelder JE, Thull A, Hausen S, Wellons Jr HA, Schneider JA. Intravenous versus intracoronary SK therapy for acute myocardial infarction in community hospitals. Am J Cardiol 1984; 54: 256-260
142 Valentine RP, Pitts DE, Brooks-Brunn JA, Williams JG, Van Hove E, Schmidt PE. Intravenous versus intracoronary SK in AMI. Am J Cardiol 1985; 55: 309-312
143 Théry C, Bauchart J, Lesenne M, Asseman P, Flajollet J-G, Legghe R, Marache P. Predictive factors of effectiveness of streptokinase in deep venous thrombosis. Am J Cardiol 1992; 69: 117-122
144 Meyerovitz MR, Polak JF, Goldhaber SZ. Short-term response to thrombolytic therapy in deep venous thrombosis: predictive value of venograph-ic appearance. Radiology 1992; 184: 345-348
145 Francis CW, Totterman S. Magnetic resonance imaging of deep vein thrombi correlates with response to thrombolytic therapy. Thromb Haemost 1995; 73: 386-391
146 Fraschini G, Jadeja J, Lawson M, Holmes FA, Carrasco HC, Wallace S. Local infusion of urokinase for the lysis of thrombosis associated with permanent central venous catheters in cancer patients. J Clin Oncol 1987; 5: 672-678
147 Druy EM, Trout III HH, Giordano JM, Hix WR. Lytic therapy in the treatment of axillary and subclavian vein thrombosis. J Vase Surg 1985; 1: 821-827
148 Becker GJ, Holden RW, Rabe FE, Castaneda-Zuniga WR, Sears N, Dilley RS, Glover JL. Local thrombolytic therapy for subclavian and axillary vein thrombosis. Treatment of the thoracic inlet syndrome. Radiology 1983; 149: 419-423
149 Francis CW, Marder VJ. Fibrinolytic therapy for venous thrombosis. Prog Cardiovasc Dis 1991; 34: 193-204
150 Molina JE, Hunter DW, Yedlicka JW. Thrombolytic therapy for iliofemoral venous thrombosis. Vase Surg 1992; 26: 630-637
151 Semba CP, Dake MD. Iliofemoral deep venous thrombosis: Aggressive therapy with catheter-directed thrombolysis. Radiology 1004; 191: 487-494
152 Comerota AJ, Aldridge SC, Cohen G, Ball DS, Pliskin M, White JV. A strategy of aggressive regional therapy for acute iliofemoral venous thrombosis with contemporary venous thrombectomy or catheter-directed thrombolysis. J Vase Surg 1994; 20: 244-254