Monocyte Tissue Factor Expression Induced by Plasmodium falciparum-Infected Erythrocytes

Gilles Pernod; Benoît Polack; François Peyron; Annick Luisy; Lucien Kolodié; Pierre Ambroise-Thomas; Ferrucio Santoro

doi:10.1055/s-0038-1656333

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1992; 68(02): 111-114
DOI: 10.1055/s-0038-1656333

Original Article

Schattauer GmbH Stuttgart

Monocyte Tissue Factor Expression Induced by Plasmodium falciparum-Infected Erythrocytes

Authors

Gilles Pernod

¹Laboratoire d'Hématologie, CNRS URA 1344, Faculté de Médecine, Grenoble, France

²Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS URA 1344, Faculté de Médecine, Grenoble, France
Benoît Polack

¹Laboratoire d'Hématologie, CNRS URA 1344, Faculté de Médecine, Grenoble, France

²Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS URA 1344, Faculté de Médecine, Grenoble, France
François Peyron

³Département de Parasitologie et Pathologie Exotique, Université Claude Bernard, Lyon, France
Annick Luisy

¹Laboratoire d'Hématologie, CNRS URA 1344, Faculté de Médecine, Grenoble, France
Lucien Kolodié

¹Laboratoire d'Hématologie, CNRS URA 1344, Faculté de Médecine, Grenoble, France
Pierre Ambroise-Thomas

²Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS URA 1344, Faculté de Médecine, Grenoble, France
Ferrucio Santoro

²Département de Parasitologie-Mycologie Médicale et Moléculaire, CNRS URA 1344, Faculté de Médecine, Grenoble, France

Abstract

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Summary

Monocytes are active elements of the host response against Plasmodium falciparum. They are able to express tissue factor and trigger the extrinsic pathway of blood coagulation the activation of which remained unclear in malaria. Our aim was to assess the tissue factor expression of purified blood monocytes stimulated by cultured Plasmodium falciparum-infected erythrocytes. Malaria parasite induced an early generation of tissue factor with a peak between 8 and 12 h of stimulation. Maximum expression was observed for parasitemia ranging from 1 to 2%. Plasmodium falciparum culture supernatants had the same effect showing the existence of a soluble factor able to induce the tissue factor expression. These data, demonstrating an activation of the tissue factor pathway by the malaria parasite, emphasize thrombin generation. Therefore, thrombin could participate in malaria pathology either in the microcirculatory blockade via platelet and fibrinogen activation or as a mitotic.

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Referenzen

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