Thrombopoietin (Mpl-ligand) and the Regulation of Platelet Production

• References

• 1 Souyri M, Vigon I, Penciolelli J-F, Heard JM, Tambourin P, Wendling F. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 1990; 63: 1137-1147
• 2 Methia N, Louache F, Vainchenker W, Wendling F. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 1993; 82: 1395-1401
• 3 Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW. Thrombocytopenia in c-mpl-deficient mice. Science 1994; 265: 1445-1447
• 4 Bartley TD, Bogenberger J, Hunt P. et al. Identification and cloning of a megakaryocyte growth and development factor that its a ligand for the cytokine receptor Mpl. Cell 1994; 77: 1117-1124
• 5 de Sauvage FJ, Hass PE, Spencer SD. et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-MPL ligand. Nature 1994; 369: 533-538
• 6 Lok S, Kaushansky K, Holly RD. et al. Cloning and expression of murine thrombopoietin and stimulation of platelet production in vivo. Nature 1994; 369: 565-568
• 7 Kato T, Ogami K, Shimada Y. et al. Purification and characterization of thrombopoietin. J Biochem 1995; 118: 229-236
• 8 Kuter DJ, Beeler DL, Rosenberg RD. The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc.Natl.Acad.Sci USA 1994; 91: 11104-11108
• 9 Wendling F, Maraskovsky E, Debili N. et al. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 1994; 369: 571-574
• 10 Harker LA, Marzec UM, Hunt P. et al. Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996; 88: 511-521
• 11 Banu N, Wang JF, Deng B, Groopman JE, Avraham H. Modulation of megakaryocytopoiesis by thrombopoietin: The c-Mpl ligand. Blood 1995; 86: 1331-1338
• 12 Choi ES, Nichol JL, Hokom MM, Homkohl AC, Hunt P. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 1995; 85: 402-413
• 13 Zeigler FC, de Sauvage F, Widmer HR. et al. In vitro megakaiyocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 1994; 84: 4045-4052
• 14 Debili N, Wendling F, Katz A. et al. The Mpl-Ligand or thrombopoietin or megakaryocyte growth and development factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 1995; 86: 2516-2525
• 15 Choi ES, Hokom MM, Bartley TD. et al. Recombinant human megakaryocyte growth and development factor (MGDF), a ligand for c-mpl, produces functional platelets in vitro. Stem Cell 1995; 95: 2973-2978
• 16 Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M. Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factof and/or interleukin-3. Blood 1996; 88: 429-436
• 17 Ku H, Yonemura Y, Kaushansky K, Ogawa M. Thrombopoietin, the ligand/or the Mpl receptor, synergizes with Steel Factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 1996; 87: 4544-4551
• 18 Sitnicka E, Lin N, Priestley GV. et al. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 1996; 87: 4998-5005
• 19 de Sauvage FJ, Carver-Moore K, Luoh SM. et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J. Exp.Med 1996; 183: 651-656
• 20 Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-mpl. Blood 1996; 87: 2162-2170
• 21 Carver-Moore K, Broxmeyer HE, Luoh SM. et al. Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. Blood 1996; 88: 803-808
• 22 Kaushansky K, Lok S, Holly RD. et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand, thrombopoietin. Nature 1994; 369: 568-571
• 23 Ulich TR, del Castillo J, Yin S. et al. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 1995; 86: 971-976
• 24 Farese AM, Hunt P, Boone T, MacVittie TJ. Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 1995; 86: 54-59
• 25 Hokom MM, Lancey D, Kinstler OB. et al. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombopenia associated with carboplatin and irradiation in mice. Blood 1995; 86: 4486-4492
• 26 Farese AM, Hunt P, Grab LB, MacVittie TJ. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia. J. Clin.Invest. 1996; 97: 2145-2151
• 27 Fibbe WE, Heemskerk DPM, Laterveer L. et al. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 1995; 86: 3308-3313
• 28 Kaushansky K, Broudy VC, Grossmann A. et al. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J. Clin.Invest. 1995; 96: 1683-1687
• 29 Grossmann A, Lenox J, Deisher TA. et al. Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice. Blood 1996; 88: 3363-3370
• 30 Molineux G, Hartley CA, McElroy P, McCrea C, McNiece IK. Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation. Blood 1996; 88: 1509-1514
• 31 Molineux G, Hartley C, McElroy P, McCrea C, McNiece IK. Megakaryocyte growth and development factor accelerates platelet recovery in peripheral blood progenitor cell transplant recipients. Blood 1996; 88: 366-376
• 32 O’Malley CJ, Rasko RL, Basser RL. et al. Administration of pegylated recombinant human megakaryocyte growth and development factor to human stimulates the production of functional platelets that show no evidence of in vitro activation. Blood 1996; 88: 3288-3298
• 33 Archimbaud E, Ottmann O, Lui Yin JA. et al. A randomised, double-blind, placebo-controlled study using PEG-rhuMGDF as an adjunct to chemotherapy for adults with de-novo acute myeloid leukaemia (AML): Early results. Blood 1996; 88 (Suppl. 01) 447
• 34 Vadhan-Raj S, Patel S, Broxmeyer HE. et al. Phase I-II investigation of recombinant human thrombopoietin (rhTPO) in patients with sarcoma receiving high dose chemotherapy (CT) with adriamycin (A) and ifosfamide (I). Blood 1996; 88 (Suppl. 01) 448
• 35 Miyakawa Y, Oda A, Druker BJ. et al. Thrombopoietin induces tyrosine phosphorylation of stat3 and stat5 in human blood platelets. Blood 1996; 87: 439-446
• 36 Toombs CF, Young CH, Glaspy JA, Vamum BC. Recombinant human megakaryocyte growth and development factor (MGDF) moderately enhances ex vivo platelet aggregation by a receptor dependent mechanism. Thrombosis Research 1995; 80: 23-33
• 37 Chen J, Herced-Harjacek L, Groopman JE, Grabarek J. Regulation of platelets activation in vitro by the c-Mpl ligand, thrombopoietin. Blood 1995; 86: 4054-4062
• 38 Harker LA, Hunt P, Marzec UM. et al. Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 1996; 87: 1833-1844
• 39 Sungaran R, Markovic B, Chong BH. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow and spleen using in situ hybridization. Blood 1996; 89: 101-107
• 40 de Gabriele G, Pennington DG. Regulation of platelet production. Brit. J. Haematol 1967; 13: 210-216
• 41 Kuter DJ, Rosenberg RD. Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit. Blood 1994; 84: 1464-1472
• 42 Cohen-Solal K, Villeval JL, Titeux M, Lok S, Vainchenker W, Wendling F. Constitutive expression of Mpl ligand transcript during thrombocytopenia and thrombocytosis. Blood 1996; 88: 2578-2584
• 43 Fielder PJ, Gurney AL, Stefanich E. et al. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 1996; 87: 2154-2161
• 44 Stoffer R, Wiestner A, Skoda RC. Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 1996; 87: 567-573
• 45 Shivdasani RA, Rosenblatt MF, Zucker-Franklin D. et al. Transcription factor NF-E2 is required for platelet formation independent of actions of thrombopoietin/MGDF in megakaryocyte development. Cell 1995; 81: 695-704
• 46 Mukai HY, Kojima H, Todokoro K. et al. Serum thrombopoietin (TPO) levels in patients with amegakaryocytic thrombocytopenia are much higher than those with immune thrombocytopenic purpura. Thrombosis and Haemostasis 1996; 76: 675-678
• 47 Ichikawa N, Ishida F, Shimodaira S, Tahara T, Kato T, Kitano K. Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenia purpura. Thrombosis and Haemostasis. 1996; 76: 156-160
• 48 Nagahisa H, Nagata Y, Ohnuki T. et al. Bone marrow stromal cells produce thrombopoietin an stimulate megakaryocyte growth and maturation but suppress proplatelet formation. Blood 1996; 87: 1309-1316