Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 1997; 78(01): 427-433
DOI: 10.1055/s-0038-1657564
DOI: 10.1055/s-0038-1657564
PLENARY LECTURE – Wright-Schulte Lecture
Coagulation Factor V: An Old Star Shines Again
Authors
Further Information
Publication History
Publication Date:
12 July 2018 (online)
-
References
- 1 Nolf P. Contribution á l’étude de la coagulation du sang. Les facteurs promordiaux, leurs origine. Arch Int Physiol 1908; 06: 1-72
- 2 Owren PA. The coagulation of blood. Investigations on a new clotting factor. Act Med Scand 1947; Suppl 128: 194-327
- 3 Ware AG, Murphy RC, Seegers WH. The function of Ac-globulin in blood clotting. Science 106 1947; 618-619
- 4 Kisiel W, Canfield WM, Ericsson LH, Davie EW. Anticoagulant properties of bovine plasma protein C following activation by thrombin. Biochemistry 1977; 16: 5824-5831
- 5 Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-1008
- 6 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, De RondeH, Van derVelden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67
- 7 Greengard JS, Sun X, Xu X, Fernandez JA, Griffin JH, Evatt B. Activated protein C resistance caused by Arg506Gln mutation in factor Va. Lancet 1994; 343: 1361-1362
- 8 Voorberg J, Roelse JC, Koopman R, Buller HR, Berends F, Ten CateJW, Mertens K, Van MourikJA. Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V. Lancet 1994; 343: 1535-1536
- 9 Zoller B, Dahlbäck B. Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis. Lancet 1994; 343: 1536-1538
- 10 Esmon CT. The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits and reconstitution of biological activity. J Biol Chem 1979; 254: 964-973
- 11 Nesheim ME, Myrmel KH, Hibbard L, Mann KG. Isolation and characterization of single chain bovine factor V. J Biol Chem 1979; 254: 508-517
- 12 Dahlbäck B. Human coagulation factor V purification and thrombin-catalyzed activation. J Clin Invest 1980; 66: 583-591
- 13 Kane WH, Majerus PW. Purification and characterization of human coagulation factor V. J Biol Chem 1981; 256: 1002-1007
- 14 Rosing J, Bakker HM, Thomassen MCLGD, Hemker HC, Tans G. Characterization of two forms of human factor Va with different cofactor activities. J Biol Chem 1993; 268: 21130-21136
- 15 Keller FG, Ortel TL, Quinn-Allen MA, Kane WH. Thrombin- catalyzed activation of recombinant human factor V. Biochemistry 1995; 34: 4118-4124
- 16 Marquette KA, Pittman DD, Kaufman RJ. The factor V B-domain provides two functions to facilitate thrombin cleavage and release of the light chain. Blood 1995; 86: 3026-3034
- 17 Ortel TL, Devore CarterD, Quinn AllenM, Kane WH. Deletion analysis of recombinant human factor V. Evidence for a phosphatidylserine binding site in the second C-type domain. J Biol Chem 1992; 267: 4189-4198
- 18 Nesheim ME, Taswell JB, Mann KG. The contribution of bovine factor V and factor Va to the activity of prothrombinase. J Biol Chem 1979; 254: 10952-10962
- 19 Guinto ER, Esmon CT, Mann KG, MacGillivray RT. The complete cDNA sequence of bovine coagulation factor V. J Biol Chem 1992; 267: 2971-2978
- 20 Jenny RJ, Pittman DD, Toole JJ, Kriz RW, Aldape RA, Hewick RM, Kaufman RJ, Mann KG. Complete cDNA and derived amino acid sequence of human factor V. Proc Natl Acad Sci USA 1987; 84: 4846-4850
- 21 Nesheim ME, Mann KG. Thrombin-catalyzed activation of single chain bovine factor V. J Biol Chem 1979; 254: 1326-1334
- 22 Monkovic D, Tracy P. Activation of human factor V by factor Xa and thrombin. Biochemistry 1990; 29: 1118-1128
- 23 Suzuki K, Dahlbäck B, Stenflo J. Thrombin-catalyzed activation of human coagulation factor V. J Biol Chem 1982; 257: 6556-664
- 24 Foster WB, Nesheim ME, Mann KG. The factor Xa-catalyzed activation of factor V. J Biol Chem 1983; 258: 13970-13977
- 25 Tans G, Nicolaes GA, Thomassen MCLGD, Hemker HC, van ZonneveldAJ, Pannekoek H, Rosing J. Activation of human factor V by meizothrombin. J Biol Chem 1994; 269: 15969-15972
- 26 Rosing J, Zwaal RFA, Tans G. Formation of meizothrombin as intermediate in factor Xa-catalyzed prothrombin activation. J Biol Chem 1986; 261: 4224-4228
- 27 Krishnaswamy S, Mann KG, Nesheim ME. The prothrombinase-catalyzed activation of prothrombin proceeds through the intermediate meizothrombin in an ordered, sequential reaction. J Biol Chem 1986; 261: 8977-8984
- 28 Guinto ER, Esmon CT. Formation of a calcium-binding site on bovine activated factor V following recombination of the isolated subunits. J Biol Chem 1982; 257: 10038-10043
- 29 Tracy PB, Eide LL, Bowie EJ, Mann KG. Radioimmunoassay of factor V in human plasma and platelets. Blood 1982; 60: 59-63
- 30 Viskup RW, Tracy PB, Mann KG. The isolation of human platelet factor V. Blood 1987; 69: 1188-1195
- 31 Bloom JW, Nesheim ME, Mann KG. Phospholipid-binding properties of bovine factor V and factor Va. Biochemistry 1979; 18: 4419-4425
- 32 Pusey ML, Mayer LD, Wei GJ, Bloomfield VA, Nelsestuen GL. Kinetic and hydrodynamic analysis of blood clotting factor V-membrane binding. Biochemistry 1982; 21: 5262-5269
- 33 van deWaart P, Bruls H, Hemker HC, Lindhout T. Interaction of bovine blood clotting factor Va and its subunits with phospholipid vesicles. Biochemistry 1983; 22: 2427-2432
- 34 Higgins DL, Mann KG. The interaction of bovine factor V and factor V-derived peptides with phospholipid vesicles. J Biol Chem 1983; 258: 6503-6508
- 35 Kalafatis M, Rand MD, Mann KG. Factor Va-membrane interaction is mediated by two regions located on the light chain of the cofactor. Biochemistry 1994; 33: 486-493
- 36 Kalafatis M, Jenny RJ, Mann KG. Identification and characterization of a phospholipid-binding site of bovine factor Va. J Biol Chem 1990; 265: 21580-21589
- 37 Ortel TL, Yoo L, Quinn-Allen MA, Kane WH. Partial glycosylation at asparagine-2181 of the second C-type domain of human factor V is the structural basis of the light chain doublet. Blood 1994; 84 no. 10 suppl. 1-387 a
- 38 Boskovic DS, Giles AR, Nesheim ME. Studies of the role of Va in the factor Xa-catalyzed activation of prothrombin, fragment 1 2-prethrombin-2, and dansyl-L-glutamyl-glycyl-L-arginine-meizo-thrombin in the absence of phospholipid. J Biol Chem 1990; 265: 10497-10505
- 39 Pryzdial EL, Mann KG. The association of coagulation factor Xa and factor Va. J Biol Chem 1991; 266: 8969-8977
- 40 Nesheim ME, Eid S, Mann KG. Assembly of the prothrombinase complex in the absence of prothrombin. J Biol Chem 1981; 256: 9874-9882
- 41 Lindhout T, Govers RiemslagJWP, van deWaart P, Hemker HC, Rosing J. Factor Va- factor Xa interaction. Effects of phospholipid vesicles of varying composition. Biochemistry 1982; 21: 5494-5502
- 42 Krishnaswamy S. Prothrombinase complex assembly contribution of protein-protein and protein-membrane interactions toward complex formation. J Biol Chem 1990; 07: 3708-3718
- 43 Nelsestuen GL, Broderius M. Interactions of prothrombin and blood-clotting factor X with membranes varying composition. Biochemistry 1977; 16: 4172-4177
- 44 Annamalai AE, Rao AK, Chiu HC, Wang D, Dutta RoyAK, Walsh PN, Colman RW. Epitope mapping of functional domains of human factor Va with human and murine monoclonal antibodies. Evidence for the interaction of heavy chain with factor Xa and calcium. Blood 1987; 70: 139-146
- 45 Kalafatis M, Xue J, Lawler CM, Mann KG. Contribution of the heavy and light chains of factor Va to the interaction with factor Xa. Biochemistry 1994; 33: 6538-6545
- 46 Tucker MM, Foster WB, Katzmann JA, Mann KG. A monoclonal antibody which inhibits the factor Va:factor Xa interaction. J Biol Chem 1983; 258: 1210-1214
- 47 Guinto ER, Esmon CT. Loss of prothrombin and of factor Xa- fiactor Va interactions upon inactivation of factor Va by activated protein C. J Biol Chem 1984; 259: 13986-13992
- 48 Nicolaes GA, Tans G, Thomassen MCLGD, Hemker HC, Pabinger I, Varadi K, Schwarz HP, Rosing J. Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 1995; 270: 21158-21166
- 49 Bakker HM, Tans G, Thomassen MCLGD, Yukelson LY, Ebberink R, Hemker HC, Rosing J. Functional properties of human factor Va lacking the Asp683- Arg709 domain of the heavy chain. J Biol Chem 1994; 269: 20662-20667
- 50 Esmon CT, Jackson CM. Conversion of prothrombin to thrombin. IV. The function of the fragment 2 region during activation in the presence of factor V. J Biol Chem 1974; 249: 7791-7797
- 51 Kotkow KJ, Deitcher SR, Furie B, Furie BC. The second kringle domain of prothrombin promotes factor Va- mediated prothrombin activation by prothrombinase. J Biol Chem 1995; 270: 4551-4557
- 52 van deWaart P, Hemker HC, Lindhout T. Interaction of prothrombin with factor Va-phospholipid complexes. Biochemistry 1984; 23: 2838-2842
- 53 Luckow EA, Lyons DA, Ridgeway TM, Esmon CT, Laue TM. Interaction of clotting factor V heavy chain with prothrombin and prethrombin 1 and role of activated protein C in regulating this interaction:analysis by analytical ultracentrifiigation. Biochemistry 1989; 28: 2348-2354
- 54 Rijn vanJLML, Govers RiemslagJWP, Zwaal RFA, Rosing J. Kinetic studies of prothrombin activation-. Effect of factor Va and phospholipids on the formation of the enzyme-substrate complex. Biochemistry 1984; 23: 4557-4563
- 55 Krishnaswamy S, Williams EB, Mann KG. The binding of activated protein C to factors V and Va. J Biol Chem 1986; 261: 9684-9693
- 56 Walker FJ, Scandella D, Fay PJ. Identification of the binding site for activated protein C on the light chain of factors V and VIII. J Biol Chem 1990; 265: 1484-1489
- 57 Heeb MJ, Kojima Y, Hackeng TM, Griffin JH. Binding sites for blood coagulation factor Xa and protein S involving residues 49-506 in factor Va. Protein Science 1996; 05: 1883-1889
- 58 Esmon CT, Owen WG, Jackson CM. A plausible mechanism for prothrombin activation by factor Xa, factor Va, phospholipid and calcium ions. J Biol Chem 1974; 249: 8045-8047
- 59 Rosing J, Tans G, Govers RiemslagJWP, Zwaal RFA, Hemker HC. The role of phospholipids and factor Va in the prothrombinase complex. J Biol Chem 1980; 255: 274-283
- 60 Suttie JW, Jackson CM. Prothrombin structure, activation and biosynthesis. Physiol Rev 1977; 57: 1-70
- 61 Husten EJ, Esmon CT, Johnson AE. The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex. J Biol Chem 1987; 262: 12953-12961
- 62 Krishnaswamy S, Vlasuk GP, Bergum PW. Assembly of the prothrombinase complex enhances the inhibition of bovine factor Xaby tick anticoagulant peptide. Biochemistry 1994; 33: 7897-7907
- 63 Mammen EF, Thomas WR, Seegers WH. Activation of purified prothrombin to autoprothrombin I or autoprothrombin II (platelet cofactor II or autoprothrombin II-A). Thromb Diathes Haemorrh 1960; 05: 218-250
- 64 Stenflo J. A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization. J Biol Chem 1976; 251: 355-363
- 65 Walker FJ. Regulation of activated protein C by a new protein A possible function for bovine protein S. J Biol Chem 1980; 255: 5521-5524
- 66 Walker FJ. Regulation of activated protein C by protein S. The role of phospholipid in factor Va inactivation. J Biol Chem 1981; 256: 11128-11131
- 67 Solymoss S, Tucker MM, Tracy PB. Kinetics of inactivation of membrane-bound factor Va by activated protein C. J Biol Chem 1988; 263: 14884-14890
- 68 Bakker HM, Tans G, Janssen ClaessenT, Thomassen MCLGD, Hemker HC, Griffin JH, Rosing J. The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C. Eur J Biochem 1992; 208: 171-178
- 69 Smirnov MD, Esmon CT. Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C. J Biol Chem 1994; 269: 816-819
- 70 Tans G, Rosing J, Thomassen MCLGD, Heeb MJ, Zwaal RF, Griffin JH. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles. Blood 1991; 77: 2641-2648
- 71 Suzuki K, Stenflo J, Dahlbäck B, Teodorsson B. Inactivation of human coagulation factor V by activated protein C. J Biol Chem 1983; 258: 1914-1920
- 72 Walker FJ, Sexton PW, Esmon CT. The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V. Biochim Biophys acta 1979; 571: 333-342
- 73 van deWaart P, Bruls H, Hemker HC, Lindhout T. Functional properties of factor Va subunits after proteolytic alterations by activated protein C. Biochim Biophys Acta 1984; 799: 38-44
- 74 Odegaard B, Mann K. Proteolysis of factor Va by factor Xa and activated protein C. J Biol Chem 1987; 262: 11233-11238
- 75 Kalafatis M, Mann KG. Role of the membrane in the inactivation of factor Va by activated protein C. J Biol Chem 1993; 268: 27246-27257
- 76 Kalafatis M, Rand MD, Mann KG. The mechanism of inactivation of human factor V and human factor Va by activated protein C. J Biol Chem 1994; 269: 31869-31880
- 77 Kalafatis M, Bertina RM, Rand MD, Mann KG. Characterization of the molecular defect in factor VR506Q. J Biol Chem 1995; 270: 4053-4057
- 78 Heeb MJ, Kojima Y, Greengard JS, Griffin JH. Activated protein C resistance:molecular mechanisms based on studies using purified Gln506-factor V. Blood 1995; 85: 3405-3411
- 79 Rosing J, Hoekema L, Nicolaes GAF, Thomassen MCLGD, Hemker HC, Varadi K, Schwarz HP, Tans G. Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 1995; 270: 27852-27858
- 80 Aparicio C, Dahlbäck B. Molecular mechanisms of activated protein C resistance. Properties of factor V isolated from an individual with homozygosity for the Arg506 to Gin mutation in the factor V gene. Biochem J 1996; 313: 467-472
- 81 Nesheim ME, Canfield WM, Kisiel W, Mann KG. Studies of the capacity of factor Xa to protect factor Va from inactivation by activated protein C. J Biol Chem 1982; 257: 1443-1447
- 82 Heeb MJ, Mesters RM, Tans G, Rosing J, Griffin JH. Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. J Biol Chem 1993; 268: 2872-2877
- 83 Heeb MJ, Rosing J, Bakker HM, Fernandez JA, Tans G, Griffin JH. Protein S binds to and inhibits factor Xa. Proc Natl Acad Sci USA 1994; 91: 2728-2732
- 84 Dahlbäck B, Hildebrand B. Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V. Proc Natl Acad Sci USA 1994; 91: 1396-1400
- 85 Shen L, Dahlbäck B. Factor V and protein S as synergistic cofactors to activated protein C in degradation of factor VIIIa. J Biol Chem 1994; 269: 18735-18738
- 86 Lu D, Kalafatis M, Mann KG, Long GL. Comparison of activated protein C/protein S-mediated inactivation of human factor VIII and factor V. Blood 1996; 87: 4708-4717
- 87 Varadi K, Rosing J, Tans G, Pabinger I, Keil B, Schwarz HP. Factor V enhances the cofactor function of protein S in the APC- mediated inactivation of factor VIII: influence of the factor VR506Q mutation. Thromb Haemostas 1996; 76 (02) 208-214
- 88 Walker FJ, Chavin SI, Fay PJ. Inactivation of factor VIII by activated protein C and protein S. Arch Biochem Biophys 1987; 252: 322-328
- 89 Fay PH, Smudzin TM, Walker FJ. Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. J Biol Chem 1991; 266: 20139-20145