Thrombosis and Haemostasis, Inhaltsverzeichnis Thromb Haemost 1997; 78(01): 631-635DOI: 10.1055/s-0038-1657602 Epidemiology of inherited thrombophilia Schattauer GmbH Stuttgart The Leiden Thrombophilia Study (LETS) Autoren Institutsangaben Felix J M van der Meer 1 Department of Hematology, Hemostasis and Thrombosis Research Center, Academic Hospital Leiden, The Netherlands T Koster 2 Department of Clinical Epidemiology, Hemostasis and Thrombosis Research Center, Academic Hospital Leiden, The Netherlands J P Vandenbroucke 2 Department of Clinical Epidemiology, Hemostasis and Thrombosis Research Center, Academic Hospital Leiden, The Netherlands E Briët 1 Department of Hematology, Hemostasis and Thrombosis Research Center, Academic Hospital Leiden, The Netherlands Frits R Rosendaal 1 Department of Hematology, Hemostasis and Thrombosis Research Center, Academic Hospital Leiden, The Netherlands 2 Department of Clinical Epidemiology, Hemostasis and Thrombosis Research Center, Academic Hospital Leiden, The Netherlands Artikel empfehlen Abstract als PDF herunterladen(opens in new window) Artikel einzeln kaufen(opens in new window) PDF (859 kb) Referenzen References 1 Miletich J, Sherman L, Broze G. Absence of thrombosis in subjects with heterozygous protein C deficiency. N Engl J Med 1987; 317: 991-996 2 Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981; 68: 1370-1373 3 Bertina RM, Broekmans AW, Van der Linden IK, Mertens K. Protein C deficiency in a Dutch family with thrombotic disease. Thromb Haemostas 1982; 48: 01-05 4 Broekmans AW, Veltkamp JJ, Bertina RM. Congenital protein C deficiency and venous thromboembolism. A study in three Dutch families. N Engl J Med 1983; 309: 340-344 5 Koster T, Rosendaal FR, Briët E, Van der Meer FJM, Colly LP, Trienekens PH, Poort SR, Reitsma PH, Vandenbroucke JP. Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study). Blood 1995; 85: 2756-2761 6 Comp PC, Esmon CT. Recurrent venous thromboembolism in patients with a partial deficiency of protein S. N Engl J Med 1984; 311: 1525-1528 7 Broekmans AW, Bertina RM, Reinalda-Poot J, Engesser L, Muller HP, Leeuw JA, Michiels JJ, Brommer EJP, Briët E. Hereditary protein S deficiency and venous thromboembolism. A study in three Dutch families. Thromb Haemost 1985; 53: 273-277 8 Engesser L, Broekmans AW, Briët E, Brommer EJP, Bertina RM. Hereditaiy protein S deficiency: clinical manifestations. Ann Intern Med 1987; 106: 677-682 9 Heijboer H, Brandjes DPM, Büller HR, Sturk A, ten Cate JW. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis. N Engl J Med 1990; 323: 1512-1516 10 Tait RC, Walker ID, Perry DJ, Islam SIAM, Daly ME, McCall F, Conkie JA, Carrell RW. Prevalence of antithrombin deficiency in the healthy population. Br J Haematol 1994; 87: 106-112 11 Koster T, Rosendaal FR, De Ronde H, Briët E, Vandenbroucke JP, Bertina RM. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993; 342: 1503-1506 12 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, De Ronde H, Van der Velden RA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-67 13 Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995; 85: 1504-1508 14 Vandenbroucke JP, Koster T, Briët E, Reitsma PH, Bertina RM, Rosendaal FR. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet 1994; 344: 1453-1457 15 Bloemenkamp KWM, Rosendaal FR, Helmerhorst FM, Büller HR, Vandenbroucke JP. Lancet 1995; 346: 1593-1596 16 Koster T, Blann AD, Briët E, Vandenbroucke JP, Rosendaal FR. Lancet 1995; 345: 152-155 17 Den Heijer M, Koster T, Blom HJ, Bos GMJ, Briët E, Reitsma PH, Vandenbroucke JP, Rosendaal FR. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996; 334: 759-762 18 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-3703
