A Glanzmann’s Thrombasthenia Cluster Among Iraqi Jews in Israel

Summary

A country-wide survey of Glanzmann’s thrombasthenia in Israel identified 44 patients. The patients belong to 23 unrelated families, 17 of whom are of Iraqi Jewish origin. The frequency of thrombasthenia among Iraqi Jews in Israel (total population 270,000) is 1:7714 and thus the calculated frequency of the carrier state is 2.3%.

Key words

Thrombasthenia - Glanzmann’s thrombasthenia - Platelet disorders

• References

• 1 Nurden AT, Caen J. An abnormal glycoprotein pattern in three cases of Glanzmann’s thrombasthenia. Br J Haematol 1974; 28: 253-260
• 2 Lightsey AL, Thomas WJ, Plow EF, McMillan R, Ginsberg M. Glanzmann’s thrombasthenia in the absence of glycoprotein II b and III deficiency. Blood 1981; 58 (Suppl) 199a
• 3 Nurden AT, Rosa JP, Boizard B, Didry D, Legrand C, Parquet A. Evidence that GP II b-III a complexes are required for ADP-induced platelet aggregation from studies on the platelets of a patient with a new type of Glanzmann’s thrombasthenia. Thromb Haemostas 1983; 50: 216 (Abstr.)
• 4 Bentegeat J, Verger P, Boisseau M, De Joigny C, Guillard JM, Le Menn R. Considérations cliniques, génétiques, biologiques et physiopathologiques sur la thrombasthenie de Glanzmann (A propos de 5 cas). Coagulation 1968; 1: 237-248
• 5 Desbuquois G, Leroux ME, Laugier J, Leroy J, Bremont JP, Rolland JC. Intérêt de la transfusion d’échange au cours des hémorrhagies graves de la thrombasthenie de Glanzmann-Naegeli chez l’enfant: A propos de 2 cas. Ann Pediatr (Paris) 1970; 17: 49-54
• 6 Levy JM, Mayer G, Sacrez R, Ruff R, Francfort JJ, Rodier L. Thrombasthenie de Glanzmann-Naegeli. Etude d’un groupe ethnique à forte endogamie Sem Hop Paris 1971; 47: 129-137
• 7 Reichert N, Seligsohn U, Ramot B. Clinical and genetic aspects of Glanzmann’s thrombasthenia in Israel. Report of 22 cases Thrombos Diathes Haemorrh 1975; 34: 806-820
• 8 Khanduri U, Pulimood R, Sudarsanam A, Corman RH, Jadhav M, Pereira S, Pulimood BM. Glanzmann’s thrombasthenia: A review of 42 cases from South India. Thromb Haemostas 1981; 46: 717-721
• 9 Awidi AS. Increased incidence of Glanzmann’s thrombasthenia in Jordan as compared with Scandinavia. Scand J Haematol 1983; 30: 218-222
• 10 Caen JP, Castaldi PA, Leclerc JG, Inceman S, Larrieu MJ, Probst M, Bernard J. Congenital bleeding disorders with long bleeding time and normal platelet count. I. Glanzmann’s thrombasthenia a report of 15 cases. Am J Med 1966; 41: 4-26
• 11 Cohen I, Glaser T, Seligsohn U. Effects of ADP and ATP on bovine fibrinogen and ristocetin-induced platelet aggregation in Glanzmann’s thrombasthenia. Br J Haematol 1975; 31: 343-347