Protein C Deficiency – Response to Danazol and DDAVP

R Gonzalez; I Alberca; N Sala; V Vicente

doi:10.1055/s-0038-1661306

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1985; 53(03): 320-322
DOI: 10.1055/s-0038-1661306

Original Article

Schattauer GmbH Stuttgart

Protein C Deficiency – Response to Danazol and DDAVP

R Gonzalez

The Department of Haematology, University of Salamanca, Barcelona, Spain

,

I Alberca

The Department of Haematology, University of Salamanca, Barcelona, Spain

,

N Sala

¹The Hospital de la Santa Cruz y San Pablo, Barcelona, Spain

,

V Vicente

The Department of Haematology, University of Salamanca, Barcelona, Spain

› Author Affiliations

Abstract

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Summary

We studied a Spanish family in which one of the female members presented recurrent thrombophlebitis in both legs after three different deliveries. Biological and antigenic activity of protein C was decreased (35% and 42% respectively). Reduced protein C levels were also observed in 6 other family members. Administration of danazol (600 mg/day) in two patients with protein C deficiency elevated this protein and discontinuation of the drug resulted in a reduction of protein C to pretreatment values. The proposita showed a normal fibrinolytic activity and infusion of DDAVP produced a similar response of FVIII/VWF and plasminogen activator to those observed in healthy subjects.

Keywords

Protein C deficiency - Recurrent thrombosis - Danazol - DDAVP

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References

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