Frailty of Obese Children: Evaluation of Plasma Antioxidant Capacity in Pediatric Obesity

F. Leo; A. N. Rossodivita; C. D. Segni; S. Raimondo; S. Canichella; A. Silvestrini; G. A. D. Miggiano; E. Meucci; A. Mancini

doi:10.1055/s-0042-105280

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2016; 124(08): 481-486
DOI: 10.1055/s-0042-105280

Article

Frailty of Obese Children: Evaluation of Plasma Antioxidant Capacity in Pediatric Obesity

Authors

F. Leo

¹Department of Medical Sciences, Division of Endocrinology, Catholic University of The Sacred Heart, Rome, Italy
A. N. Rossodivita

²Institute of Pediatrics, Catholic University of The Sacred Heart, Rome, Italy
C. D. Segni

¹Department of Medical Sciences, Division of Endocrinology, Catholic University of The Sacred Heart, Rome, Italy
S. Raimondo

¹Department of Medical Sciences, Division of Endocrinology, Catholic University of The Sacred Heart, Rome, Italy
S. Canichella

³Department of Laboratory Medicine, Dietetic Service, Catholic University of the Sacred Heart, Rome, Italy
A. Silvestrini

⁴Institute of Biochemistry and Clinical Biochemistry, Catholic University of The Sacred Heart, Rome, Italy
G. A. D. Miggiano

³Department of Laboratory Medicine, Dietetic Service, Catholic University of the Sacred Heart, Rome, Italy

⁴Institute of Biochemistry and Clinical Biochemistry, Catholic University of The Sacred Heart, Rome, Italy
E. Meucci

⁴Institute of Biochemistry and Clinical Biochemistry, Catholic University of The Sacred Heart, Rome, Italy
A. Mancini

¹Department of Medical Sciences, Division of Endocrinology, Catholic University of The Sacred Heart, Rome, Italy

Abstract

Background: Obese children are subject to the same chronic oxidative and inflammatory stress, responsible for the onset of all the complications typical of adult age, such as insulin resistance, type 2 diabetes, dyslipidemia and cardiovascular disease.

Objectives: Since few studies are reported in prepubertal obese children, we investigated the relationship between oxidative stress, body composition and metabolic pattern in childhood obesity in comparison with adult obese patients.

Methods: We enrolled 25 prepubertal children (12 males and 13 females) aged 5–12 years with a mean value of standard deviation of BMI (SDS-BMI)±SEM of 1.96±0.09. We performed oral glucose tolerance test, hormonal and metabolic evaluation, bioimpedentiometry, evaluation of total antioxidant capacity using spectroscopical method using a radical cation, 2,2^I- azinobis(3-ethylbenzothiazoline-6 sulphonate) (ABTS), as indicator of radical formation, with a latency time (LAG) proportional to antioxidant in the sample.

Results: LAG values significantly correlate with % fat mass, waist circumference and waist/hip ratio. However mean LAG values were significantly lower than in obese adults.

Conclusions: We suggest that children are more susceptible to oxidative stress than adults, possibly to incomplete development of antioxidant system. Prognostic and therapeutical implications need to be further investigated.

Key words

oxidative stress - obesity - childhood - antioxidants - metabolic syndrome - insulin resistance

Full Text

References

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