Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study

Andréia Cristiane Carrenho Queiroz; Julio Cesar Silva Sousa Jr.; Natan Daniel Silva Jr.; Eleonora Tobaldini; Katia Coelho Ortega; Edilamar Menezes de Oliveira; Patricia Chakur Brum; Nicola Montano; Decio Mion Jr.; Taís Tinucci; Claudia Lucia de Moraes Forjaz

doi:10.1055/s-0042-123044

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2017; 38(04): 270-277
DOI: 10.1055/s-0042-123044

Physiology & Biochemistry

Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study

Andréia Cristiane Carrenho Queiroz

¹School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil

²Federal University of Juiz de Fora, Minas Gerais, Brazil

,

Julio Cesar Silva Sousa Jr.

¹School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil

,

Natan Daniel Silva Jr.

¹School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil

,

Eleonora Tobaldini

³Department of Biomedical and Clinical Sciences “L. Sacco”, Medicine and Physiopathology, L. Sacco Hospital, University of Milan, Milan, Italy

,

Katia Coelho Ortega

⁴General Hospital, University of São Paulo, São Paulo, Brazil

,

Edilamar Menezes de Oliveira

¹School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil

,

Patricia Chakur Brum

¹School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil

,

Nicola Montano

³Department of Biomedical and Clinical Sciences “L. Sacco”, Medicine and Physiopathology, L. Sacco Hospital, University of Milan, Milan, Italy

,

Decio Mion Jr.

⁴General Hospital, University of São Paulo, São Paulo, Brazil

,

Taís Tinucci

¹School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil

,

Claudia Lucia de Moraes Forjaz

¹School of Physical Education and Sport, University of Sao Paulo, São Paulo, Brazil

› Institutsangaben

Abstract

To evaluate whether captopril (3×50 mg/day) potentiates post-resistance exercise hypotension (PREH) in hypertensives (HT), 12 HT men received captopril and placebo for 4 weeks each in a double-blinded, randomized-crossover design. On each therapy, subjects underwent 2 sessions: Control (C – rest) and Resistance Exercise (RE – 7 exercises, 3 sets to moderate fatigue, 50% of 1 RM –repetition maximum). Measurements were taken before and after 30–60 min (Post1) and 7 h (Post2), and ambulatory blood pressure (BP) was monitored for 24 h. There were no differences in PREH characteristics and mechanisms between the placebo and captopril periods. At Post1, systolic/diastolic BP decreased significantly and similarly after RE with both therapies (Placebo=−13±2/−9±1 mmHg vs. Captopril=−12±2/−10±1 mmHg, P<0.05). RE reduced cardiac output in some subjects and systemic vascular resistance in others. Heart rate and cardiac sympathetic modulation increased, while stroke volume and baroreflex sensitivity decreased after RE (Placebo: +13±2 bpm, +21±5 nu, −11±5 ml, −4±2 ms/mmHg; Captopril: +13±2 bpm, +35±4 nu, 17±5 ml, −3±1 ms/mmHg, P<0.05). At Post2, all variables returned to pre-intervention values. Ambulatory BP was similar between the sessions. Thus, captopril did not potentiate the magnitude and duration of PREH in HT men, and it did not influence PREH mechanisms.

Key word

hypertension - angiotensin I-converting enzyme inhibitor - blood pressure - autonomic modulation - strength exercise - placebo-controlled

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