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DOI: 10.1055/s-0045-1802583
Imaging Findings in Amyloid Arthropathy of the Hip Joints: The Eyes Cannot See What the Mind Does Not Know
Autor*innen
Funding None.
Abstract
Amyloid arthropathy is a rare but serious complication in patients with chronic renal failure with a history of prolonged hemodialysis. The underlying pathophysiology is the accumulation of beta-2 microglobulin in intra- and periarticular tissues, with consequent synovial thickening and erosions. Imaging-based diagnosis of amyloid arthropathy allows prompt clinical management and better patient outcomes. In view of vague clinical presentation and uncommon incidence, the radiologist is often the first one to suspect this complication. We hereby describe the case of a 66-year-old man with gradually progressive left hip pain for the past 6 months who was diagnosed to have bilateral amyloid arthropathy and was subsequently confirmed with computed tomography (CT) guided synovial biopsy. Amyloid arthropathy should be considered in patients with hip pain who are on long-term hemodialysis and present with suggestive findings on radiograph, CT, and magnetic resonance studies.
Publikationsverlauf
Artikel online veröffentlicht:
12. Februar 2025
© 2025. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Sipe JD, Benson MD, Buxbaum JN. et al; Nomenclature Committee of the International Society of Amyloidosis. Amyloid fibril protein nomenclature: 2012 recommendations from the Nomenclature Committee of the International Society of Amyloidosis. Amyloid 2012; 19 (04) 167-170
- 2 Merlini G, Seldin DC, Gertz MA. Amyloidosis: pathogenesis and new therapeutic options. J Clin Oncol 2011; 29 (14) 1924-1933
- 3 Wininger AE, Phelps BM, Le JT, Harris JD, Trachtenberg BH, Liberman SR. Musculoskeletal pathology as an early warning sign of systemic amyloidosis: a systematic review of amyloid deposition and orthopedic surgery. BMC Musculoskelet Disord 2021; 22 (01) 51
- 4 Gejyo F, Yamada T, Odani S. et al. A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin. Biochem Biophys Res Commun 1985; 129 (03) 701-706
- 5 Bardin T, Zingraff J, Shirahama T. et al. Hemodialysis-associated amyloidosis and beta-2 microglobulin. Clinical and immunohistochemical study. Am J Med 1987; 83 (03) 419-424
- 6 Kiss E, Keusch G, Zanetti M. et al. Dialysis-related amyloidosis revisited. AJR Am J Roentgenol 2005; 185 (06) 1460-1467
- 7 Otake S, Tsuruta Y, Yamana D, Mizutani H, Ohba S. Amyloid arthropathy of the hip joint: MR demonstration of presumed amyloid lesions in 152 patients with long-term hemodialysis. Eur Radiol 1998; 8 (08) 1352-1356
- 8 Georgiades CS, Neyman EG, Barish MA, Fishman EK. Amyloidosis: review and CT manifestations. Radiographics 2004; 24 (02) 405-416
- 9 Loizos S, Chrysa TS, Christos GS. Amyloidosis: review and Imaging Findings. Seminars in Ultrasound. CT and MRI 2014; 35 (03) 225-239
- 10 Scarpioni R, Ricardi M, Albertazzi V, De Amicis S, Rastelli F, Zerbini L. Dialysis-related amyloidosis: challenges and solutions. Int J Nephrol Renovasc Dis 2016; 9: 319-328
- 11 Hoshino J, Yamagata K, Nishi S. et al. Significance of the decreased risk of dialysis-related amyloidosis now proven by results from Japanese nationwide surveys in 1998 and 2010. Nephrol Dial Transplant 2016; 31 (04) 595-602
- 12 Campistol JM. Dialysis-related amyloidosis after renal transplantation. Semin Dial 2001; 14 (02) 99-102