The Effect of Moderate Aerobic Exercise and Relaxation on Secretory Immunoglobulin A

A deficiency in secretory immunoglobulin A (sIgA) is associated with recurrent upper respiratory tract infections both in the general community and in elite athletes. The aim of this paper was to investigate the effect of aerobic exercise and relaxation on various indices of sIgA in 12 male and 8 female adults who varied in levels of recreational activity. Salivary samples were obtained before, immediately after and 30 minutes after an incremental cycle ergometer test to fatigue, after 30 minutes of cycling at 30 % or 60 % of maximum heart rate, and after 30 minutes of relaxation with guided imagery. Each session was run on a separate day. When expressed in relation to changes in salivary flow rate, sIgA did not change after exercise. However, both the absolute concentration and secretion rate of sIgA increased during relaxation (167 ± 179 μg · ml^-1, p < 0.001; and 37 ± 71 μg · min^-1, p < 0.05 respectively). Nonspecific protein increased more than sIgA during incremental exercise to fatigue (decrease in the sIgA/protein ratio 92 ± 181 μg · mg protein^-1, p < 0.05), but sIgA relative to protein did not change during relaxation. Our findings suggest that sIgA secretion rate is a more appropriate measure of sIgA than sIgA relative to protein, both for exercise and relaxation. These data suggest the possibility of using relaxation to counteract the negative effects of intense exercise on sIgA levels.

Key words:

Exercise, relaxation, immunoglobulin A, saliva.

References

• 01 Ammann A, Hong R. Selective IgA deficiency: presentation of 30 cases and a review of the literature.  Medicine. 1971;  50 223-236
• 02 Biddle S JH. Exercise psychology.  Sport Science Review. 1995;  1 79-92
• 03 Blannin A K, Robson J, Walsh N P, Clark A M, Glennon L, Gleeson M. The effect of exercising to exhaustion at different intensities on saliva immunoglobulin A, protein and electrolyte secretion.  Int J Sports Med. 1998;  19 547-552
• 04 Cohen S, Tyrrell D AJ, Smith A P. Psychological stress and susceptibility to the common cold.  N Engl J Med. 1991;  325 606-612
• 05 Dillon K M, Minchoff B, Baker K. Positive emotional states and enhancement of the immune system.  Int J Psychiatr Med. 1985;  15 13-17
• 06 Dillon K M, Totten M C. Psychological factors, immunocompetence, and health of breast-feeding mothers and their infants.  J Genet Psychol. 1989;  150 155-162
• 07 Gleeson M, McDonald A W, Cripps A W, Pyne D B, Clancy R L, Fricker P A. The effect on immunity of long term intensive training in elite swimmers.  Clin Exp Immunol. 1995;  102 210-216
• 08 Green M L, Green R G, Santoro W. Daily relaxation modifies serum and salivary immunoglobulins and psychophysiologic symptom severity.  Biofeed Self Reg. 1988;  13 187-199
• 09 Green R G, Green M L. Relaxation increases salivary immunoglobulin A.  Psychol Reports. 1987;  61 623-629
• 10 Gregerson M B, Roberts I M, Amiri M M. Absorption and imagery locate immune response in the body.  Biofeed Self Reg. 1996;  21 149-165
• 11 Heath G W, Ford E S, Craven T E, Macera C A, Jackson K L, Pate R R. Exercise and the incidence of upper respiratory tract infections.  Med Sci Sports Exerc. 1991;  23 152-157
• 12 Hewson-Bower B, Drummond P D. Secretory immunoglobulin A increases during relaxation in children with and without recurrent upper respiratory tract infections.  Devel Behav Pediatr. 1996;  17 311-316
• 13 Housh T J, Johnson G O, Housh D J, Evans S L, Tharp G D. The effect of exercise at various temperatures on salivary levels of immunoglobulin A.  Int J Sports Med. 1991;  12 498-500
• 14 Janoski M L, Kugler J. Relaxation, imagery, and neuroimmunomodulation.  Ann NY Acad Sci. 1987;  496 722-730
• 15 Ljungberg G, Erikson T, Ekblom B, Birkhed D. Saliva and marathon running.  Scand J Med Sci Sports. 1997;  7 214-219
• 16 Mackinnon L T. Immunoglobulin, antibody, and exercise.  Exerc Immunol Rev. 1996;  2 1-35
• 17 Mackinnon L T, Chick T W, Van As A, Tomasi T B. Decreased secretory immunoglobulins following intense endurance exercise.  Sports Training Med Rehab. 1989;  1 209-218
• 18 Mackinnon L T, Ginn E, Seymour G J. Decreased salivary immunoglobulin A secretion rate after intense interval exercise in elite kayakers.  Eur J Appl Physiol. 1993;  67 180-184
• 19 Mackinnon L T, Hooper S. Mucosal (secretory) immune system responses to exercise of varying intensity and during overtraining.  Int J Sports Med. 1994;  15 S 179-S 183
• 20 Mackinnon L T, Jenkins D G. Decreased salivary immunoglobulins after intense interval exercise before and after training.  Med Sci Sports Exer. 1993;  25 678-683
• 21 Mazanec M B, Nedrud J G, Kaetzel C S, Lamm M E. A three-tiered view of the role of IgA in mucosal defence.  Immunol Today. 1993;  14 430-435
• 22 McDowell S L, Chaloa K, Housh T J, Tharp G D, Johnson G O. The effect of exercise intensity and duration on salivary immunoglobulin A.  Eur J Appl Physiol. 1991;  63 108-111
• 23 Nieman D C. Exercise, upper respiratory tract infection, and the immune system.  Med Sci Sports Exer. 1993;  26 128-139
• 24 Nieman D C, Johanssen L M, Lee J W, Arabatzis K. Infectious episodes in runners before and after the Los Angeles marathon.  J Sports Med Phys Fitness. 1990;  30 316-328
• 25 Olness K, Culbert T, Uden D. Self-regulation of salivary immunoglobulin A by children.  Pediatrics. 1989;  83 66-71
• 26 Peters E M, Bateman E D. Ultra marathon running and upper respiratory tract infections.  South Afr Med J. 1983;  64 582-584
• 27 Plante T G, Rodin J. Physical fitness and enhanced psychological health.  Curr Psychol Res Rev. 1990;  9 3-24
• 28 Pyne D B, Gleeson M. Effects of intensive exercise training on immunity in athletes.  Int J Sports Med. 1998;  19 S 183-S 194
• 29 Rider M S, Weldin C W. Imagery, improvisation and immunity.  Arts Psychother. 1990;  17 211-216
• 30 Rider M S, Achterberg J, Lawlis G F, Goven A, Toledo R, Butler J R. Effects of immune system imagery on secretory IgA.  Biofeed Self Reg. 1990;  15 317-333
• 31 Ring C, Carroll D, Willemsen G, Cooke J, Ferraro A, Drayson M. Secretory immunoglobulin A and cardiovascular activity during mental arithmetic and paced breathing.  Psychophysiol. 1999;  36 602-609
• 32 Stone A A, Cox D S, Valdimarsdottir H, Neale J M. Secretory IgA as a measure of immunocompetence.  J Human Stress. 1987;  13 136-140
• 33 Tharp G D. Basketball exercise and secretory immunoglobulin A.  Eur J Appl Physiol. 1991;  63 312-314
• 34 Tharp G D, Barnes M W. Reduction of saliva immunoglobulin levels by swim training.  Eur J Appl Physiol. 1990;  60 61-64
• 35 Tomasi T B, Trudeau F B, Czerwinski D, Erredge S. Immune parameters in athletes before and after strenuous exercise.  J Clin Immunol. 1982;  2 173-178
• 36 Walsh N P, Blannin A K, Clark A M, Cook L, Robson P J, Gleeson M. The effects of high-intensity intermittent exercise on saliva IgA, total protein and α-amylase.  J Sports Sci. 1999;  17 129-134
• 37 Willemsen G, Ring C, Carroll D, Evans P, Clow A, Hucklebridge F. Secretory immunoglobulin A and cardiovascular reactions to mental arithmetic and cold pressor.  Psychophysiol. 1998;  35 252-259
• 38 Winzer A, Ring C, Carroll D, Willemsen G, Drayson M, Kendall M. Secretory immunoglobulin A and cardiovascular reactions to mental arithmetic, cold pressor, and exercise: effects of beta-adrenergic blockade.  Psychophysiol. 1999;  36 591-601