Abstract
Our data demonstrate that serum lipid and lipoprotein levels
continue to track from childhood into young adulthood. The persistence and
clustering of multiple CVD risk factors from childhood to adulthood and the
impact of obesity in this regard point to the need for preventive measures
aimed at developing healthy lifestyles early in life. Adverse levels of LDL-C
in childhood persist over time, progress to adult dyslipidemias, and relate to
obesity and hypertension as well. NCEP guidelines which classify CVD risk on
the basis of LDL-C level, are helpful in targeting individuals at risk early in
life.
Key words
Dyslipidemia - lipids - lipoproteins - tracking
References
1
Bao W, Srinivasan S R, Wattigney W A, Bao W, Berenson G S.
Persistence of multiple cardiovascular risk clustering
related to syndrome x from childhood to young adulthood.
Arch Intern Med.
1994;
154
1842-1847
2
Bao W, Srinivasan S R, Wattigney W A, Bao W, Berenson G S.
Usefulness of childhood low-density lipoprotein cholesterol
level in predicting adult dyslipidemias and other cardiovascular risks.
Arch Intern Med.
1996;
156
1315-1320
3
Bao W, Threefoot S A, Srinivasan S R, Berenson G S.
Essential hypertension predicted by tracking of elevated
blood pressure from childhood to adulthood: the Bogalusa Heart Study.
Am J Hypertens.
1995;
8
657-665
4
Bao W, Srinivasan S R, Valdez R, Greenlund K J, Wattigney W A, Berenson G S.
Longitudinal changes in cardiovascular risk from childhood to
young adulthood in offspring of parents with coronary artery disease: the
Bogalusa Heart Study.
JAMA.
1997;
278
1749-1754
5
Berenson G S, Strong W B, Williams C. et al .
An American Health Foundation monograph. Coronary artery
disease prevention: cholesterol, a pediatric perspective.
Prev Med.
1989;
18
323-409
6 Berenson G S, Srinivason S R, Webber L S. et al .Cardiovascular risk in early life.
The Bogalusa Heart Study.
Current Concepts. Kalamazoo, MI; Upjohn Company 1991
7
Consensus Conference .
Lowering blood cholesterol to prevent heart disease.
JAMA.
1985;
253
2080-2086
8
Grundy S M, Denke M A.
Dietary influences on serum lipids and lipoproteins.
J Lipid Res.
1990;
31
1149-1172
9
Kannel W B, D'Agostino R B, Belanger A J.
Concept of bridging the gap from youth to adulthood.
Am J Med Sci.
1995;
310
S15-21
10
Lenfant C, Savage P J.
The early natural history of atherosclerosis and hypertension
in the young: National Institutes of Health perspectives.
Am J Med Sci.
1995;
310
S3-7
11
Myers L, Coughlin S S, Webber L S, Srinivasan S R, Berenson G S.
Prediction of adult cardiovascular multifactorial risk status
from childhood risk factor levels: the Bogalusa Heart Study.
Am J Epidemiol.
1995;
142
918-924
12
Wattigney W A, Webber L S, Srinivasan S R, Berenson G S.
The emergence of clinically abnormal levels of cardiovascular
disease risk factor variables among young adults: the Bogalusa Heart
Study.
Prev Med.
1995;
24
617-626
13
Webber L S, Srinivasan S R, Wattigney W A, Berenson G S.
Tracking of serum lipids and lipoproteins from childhood to
adulthood: the Bogalusa Heart Study.
Am J Epidemiol.
1991;
133
884-899
14 World Health Statistics Annual 1991 .Geneva, Switzerland; World Health Organization
1992
G. S. Berenson, MD
Professor and Director of the Tulane Center for Cardiovascular
Health · Department of Epidemiology, Tulane School of Public Health and
Tropical Medicine
1440 Canal St., Suite 2140 · New Orleans, Louisiana 70112
· USA ·
Phone: +1-504-585-7182
Fax: +1-504-585-7194
Email: berenson@tulane.edu