Ocular Manifestations of Sarcoidosis

Deborah Bradley; Robert P. Baughman; Lawrence Raymond; Adam H. Kaufman

doi:10.1055/s-2002-36518

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2002; 23(6): 543-548
DOI: 10.1055/s-2002-36518

Ocular Manifestations of Sarcoidosis

Deborah Bradley¹ , Robert P. Baughman¹ , Lawrence Raymond² , Adam H. Kaufman²

¹Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio
²Department of Ophthalmology, University of Cincinnati Medical Center, Cincinnati, Ohio

Abstract

ABSTRACT

Ophthalmic involvement in sarcoidosis may cause significant sight-threatening illness for patients. Studies of patients with histologically proven sarcoidosis have found 25 to 50% of patients to have ocular manifestations.[1] The frequency in which eye disease is seen and the course that it takes vary with age, race, and geography.[2] [3] This article discusses relevant aspects of the ocular manifestations of sarcoidosis for the internist and pulmonologist. Overall disease presentation, specific types of ocular involvement, evaluation strategies, and treatment considerations are discussed.

KEYWORD

iritis - uveitis - vitritis - pars planitis - scleritis - ocular manifestations - sarcoidosis

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References

REFERENCES

1 Hunter D G, Foster C S. Ocular manifestations of sarcoidosis. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology Philadelphia: WB Saunders 1994: 1217-1224
2 Izumi T. Symposium: population differences in clinical features and prognosis of sarcoidosis throughout the world. Sarcoidosis . 1992; 9(suppl) S105-S118
3 Angi M R, De Caro G, Bergamo L. Low prevalence of uveitis in Italian sarcoidosis patients. Sarcoidosis . 1991; 8 181-182
4 Stavrou P, Foster C S. Sarcoidosis. In: Foster CS, Vitale AT, eds. Diagnosis and Treatment of Uveitis Philadelphia: WB Saunders 2002: 710-725
5 James D G. Ocular sarcoidosis. Ann N Y Acad Sci . 1986; 465 551-563
6 Raymond L A, Spaulding A G, Vilter R W. Peripheral retinal neovascularization in sarcoidosis with thalassemia. Ann Ophthalmol. 978; 10 745-748
7 Hoover D L, Khan J A, Giangiacomo J. Pediatric ocular sarcoidosis. Surv Ophthalmol . 1986; 30 215-228
8 Rothova A. Ocular involvement in sarcoidosis. Br J Ophthalmol . 2000; 84 110-116
9 Blau E B. Familial granulomatous arthritis, iritis, and rash. J Pediatr . 1985; 107 689-693
10 Manouvrier-Hanu S, Puech B, Peitte F. Blau syndrome of granulomatous arthritis, iritis, and skin rash: a new family and review of the literature. Am J Med Gen . 1998; 76 217-221
11 Tromp G, Kuivaniemi H, Raphael S. Genetic linkage of familial granulomatous inflammatory arthritis, skin rash, and uveitis to chromosome 16. Am J Hum Genet . 1996; 59 1097-1107
12 Siltzbach L E, James D G, Neville E. Course and prognosis of sarcoidosis around the world. Am J Med . 1974; 57 847-852
13 Yamaguchi M, Hosada Y, Sasaki R. Epidemiological study on sarcoidosis in Japan: recent trends in incidence and prevalence rates and changes in epidemiological features. Sarcoidosis . 1989; 6 138
14 Rothova A, Alberts C, Glasius E. Risk factors for ocular sarcoidosis. Doc Ophthalmol . 1989; 72 287-296
15 Samson C M, Waheed N, Baltatzis S. Methotrexate therapy for chronic noninfectious uveitis. Ophthalmology . 2001; 108 1134-1139
16 Baughman R P, Winget D B, Lower E E. Methotrexate is steroid sparing in acute sarcoidosis: results of a double blind, randomized trial. Sarcoidosis Vasc Diffuse Lung Dis . 2000; 17 60-66
17 Baughman R P. Methotrexate for sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis . 1998; 15 147-149
18 Baughman R P, Lower E E. A clinical approach to the use of methotrexate for sarcoidosis. Thorax . 1999; 54 742-746
19 Dev S, McCallum R M, Jaffe G J. Methotrexate treatment for sarcoid-associated panuveitis. Ophthalmology . 1999; 106 111-118
20 Dana M R, Merayo-Lloves J, Schaumberg D A. Prognosticators for visual outcome in sarcoid uveitis. Ophthalmology . 1996; 103 1846-1853
21 Baughman R P, Lower E E, Bradley D A, Kaufman A H. Use of cytotoxic therapy for chronic ophthalmic sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis . 1999; 16(suppl) S17
22 Baughman R P, Ohmichi M, Lower E E. Combination therapy for sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis . 2001; 18 133-137
23 Edelsten C, Pearson A, Joynes E. The ocular and systemic prognosis of patients presenting with sarcoid uveitis. Eye . 1999; 13(pt 6) 748-753
24 Kaye G B, Salmon J F, Isaacs S. Risk factors for uveitis in sarcoidosis. S Afr Med J . 1993; 83 342-344
25 Jabs D A, Johns C J. Ocular involvement in chronic sarcoidosis. Am J Ophthalmol . 1986; 102 297-301
26 Martinetti M, Tinelli C, Kolek V. ``The Sarcoidosis Map'': a joint survey of clincal and immunogenetic findings in two European countries. Am J Respir Crit Care Med . 1995; 152 557-564
27 Merritt J C, Whitsett C F, Daffin L. HLA-A, -B, and -DR antigenic factors in ocular sarcoidosis. Am J Ophthalmol . 1983; 96 396-397
28 Baughman R P, Teirstein A S, Judson M A. A Case Control Etiologic Study of Sarcoidosis (ACCESS) Research Group. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med . 2001; 164 1885-1889
29 Rothova A, Suttorp-van Schulten S M, Frits T W. Causes and frequency of blindness in patients with intraocular inflammatory disease. Br J Ophthalmol . 1996; 80 332-336
30 Dresner M S, Brecher R, Henkind P. Ophthalmology consultation in the diagnosis and treatment of sarcoidosis. Arch Intern Med . 1986; 146 301-304
31 Hunninghake G W, Costabel U, Ando M. ATS/ ERS/WASOG statement on sarcoidosis. Am J Resp Crit Care Med 1999;160:736-755; Sarcoidosis Vasc Diffuse Lung Dis . 1999; 16 149-173
32 Johns C J, Michele T M. The clinical management of sarcoidosis: a 50-year experience at the Johns Hopkins Hospital. Medicine (Baltimore) . 1999; 78 65-111
33 Obenauf C D, Shaw H E, Sydnor C F. Sarcoidosis and its ophthalmic manifestations. Am J Ophthalmol . 1978; 86 648-655