Leitlinien zur Therapie der akuten Manie

Zusammenfassung

Offizielle Therapieempfehlungen zur Therapie akuter Manien gibt es sowohl auf nationaler als auch auf internationaler Ebene. Sie werden auf der Basis der wissenschaftlichen Evidenz von einer Expertenkommission für die jeweiligen Psychopharmaka oder Therapiestrategien erstellt und in eine in der klinischen Praxis einsetzbare Form gebracht. Die World Federation of Societies of Biological Psychiatry (WFSBP) hat im Jahre 2003 solche Therapieempfehlungen publiziert. Sie geben einen Überblick über die relevanten Psychopharmakastudien zur akuten Manietherapie und zeigen einen Algorithmus auf, der sich an der Schwere der manischen Episode orientiert. Dabei gibt es vier Evidenzkategorien (A - D), die Auskunft über die Qualität der vorhandenen Studien geben.

Abstract

There are several national and international practice guidelines on the treatment of acute mania. Their purpose is to assess the available evidence of efficacy for medication used in the treatment of bipolar mania and to grade it according to the quality of studies available. The World Federation of Societies of Biological Psychiatry (WFSBP) has developed such guidelines in 2003. They categorize the scientific quality of the studies into four levels of evidence (A - D) and provide an algorithm based on the degree of severity of the acute manic episode.

Literatur

• 1 Suppes T, Dennehy E B, Swann A C, Bowden C L, Calabrese J R, Hirschfeld R M. et al . Report of the Texas Consensus Conference Panel on medication treatment of bipolar disorder 2000.  J Clin Psychiatry. 2002;  63 (4) 288-299
• 2 Licht R W, Vestergaard P, Kessing L V, Larsen J K, Thomsen P H. Psychopharmacological treatment with lithium and antiepileptic drugs: suggested guidelines from the Danish Psychiatric Association and the Child and Adolescent Psychiatric Association in Denmark.  Acta Psychiatr Scand Suppl. 2003;  (419) 1-22
• 3 Grunze H, Kasper S, Goodwin G, Bowden C, Baldwin D, Licht R W. et al . The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders, Part II: Treatment of Mania.  World J Biol Psychiatry. 2003;  4 (1) 5-13
• 4 American Psychiatric Association . Practice guideline for the treatment of patients with bipolar disorder. (Revision).  Am J Psychiatry. 2002;  159 (4 Suppl) 1-50
• 5 Bauer M S, Callahan A M, Jampala C, Petty F, Sajatovic M, Schaefer V. et al . Clinical practice guidelines for bipolar disorder from the Department of Veterans Affairs [see comments].  J Clin Psychiatry. 1999;  60 (1) 9-21
• 6 Bowden C L. New concepts in mood stabilization: evidence for the effectiveness of valproate and lamotrigine.  Neuropsychopharmacology. 1998;  19 (3) 194-199
• 7 McElroy S L, Pope H GJ, Keck P E, Hudson G F, Phillips K A, Strakowski S M. Are impulse-control disorders related to bipolar diosrder?.  Compr Psychiatry. 1996;  (37) 229-240
• 8 Poolsup N, Li-Wan P A, Olivera I R De. Systematic overview of lithium treatment in acute mania.  J Clin Pharm Ther. 2000;  25 139-156
• 9 Freeman T W, Clothier J L, Pazzaglia P, Lesem M D, Swann A C. A double-blind comparison of valproate and lithium in the treatment of acute mania.  Am J Psychiatry. 1992;  149 (1) 108-111
• 10 Bowden C L, Brugger A M, Swann A C, Calabrese J R, Janicak P G, Petty F. et al . Efficacy of divalproex vs. lithium and placebo in the treatment of mania.  Journal of the American Medical Association. 1994;  271 (12) 918-924
• 11 Pope H G, McElroy S L, Keck P E, Hudson J L. Valproate in the treatment of acute mania.  Arch Gen Psychiatry. 1991;  48 62-68
• 12 Emrich H M, Zerssen D von, Kissling W, Möller H J, Windorfer A. Effect of sodium valproate on mania. The GABA-hypothesis of affective disorders.  Arch Psychiatr Nervenkr. 1980;  229 1-16
• 13 Keck P E, McElroy S L, Tugrul K C, Bennett J A. Valproate oral loading in the treatment of acute mania.  J Clin Psychiatry. 1993;  54 305-308
• 14 Swann A C, Bowden C L, Calabrese J R, Dilsaver S C, Morris D D. Differential effect of number of previous episodes of affective disorder on response to lithium or divalproex in acute mania.  Am J Psychiatry. 2000;  156 1264-1266
• 15 Berk M, Ichim L, Brook S. Olanzapine compared to lithium in mania: a double-blind randomized controlled trial.  Int Clin Psychopharmacol. 1999;  14 (6) 339-343
• 16 Tohen M, Sanger T M, McElroy S L, Tollefson G D, Chengappa K N, Daniel D G. et al . Olanzapine versus placebo in the treatment of acute mania. Olanzapine HGEH Study Group.  Am J Psychiatry. 1999;  156 (5) 702-709
• 17 Tohen M, Jacobs T G, Grundy S L, McElroy S L, Banov M C, Janicak P G. et al . Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzapine HGGW Study Group.  Arch Gen Psychiatry. 2000;  57 (9) 841-849
• 18 Sachs G S, Grossman F, Ghaemi S N, Okamoto A, Bowden C L. Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety.  Am J Psychiatry. 2002;  159 1146-1154
• 19 Yatham L N. Efficacy and tolerability of risperidone as combination therapy in bipolar mania: results from a randomised, double-blind study.  Eur Neuropsychopharmacol. 2000;  10 (Suppl 3) 250
• 20 Tohen M, Baker R W, Altshuler L L, Zarate C A, Suppes T, Ketter T A. et al . Olanzapine versus divalproex in the treatment of acute mania.  Am J Psychiatry. 2002;  159 (6) 1011-1017
• 21 Bowden C L, Grunze H, Mullen J. A randomized, double-blind, placebo-controlled efficacy and safety study of quetiapine or lithium as monotherapy for mania in bipolar disorder.  J Clin Psychiatry. 2005;  66 111-121
• 22 Keck P E, Ice K. Ziprasidone in acute mania. Abstract No 224. APA 2000
• 23 Keck Jr P E, Versiani M, Potkin S, West S A, Giller E, Ice K. Ziprasidone in the treatment of acute bipolar mania: a three-week, placebo-controlled, double-blind, randomized trial.  Am J Psychiatry. 2003;  160 (4) 741-748
• 24 Potkin S G, Keck P E, Segal S, Ice K, English P. Ziprasidone in acute bipolar mania: a 21-day randomized double-blind, placebo-controlled replication trial.  J Clin Psychiatry. 2005;  25 (4) 301-310
• 25 Licht R W. Drug treatment of mania: a critical review.  Acta Psychiatr Scand. 1998;  97 (6) 387-397
• 26 Weisler R H, Kalali A H, Ketter T A. SPD417 Study Group . A multicenter, randomized, double-blind, placebo-controlled trial of extended-release carbamazepine capsules as monotherapy for bipolar disorder patients with manic or mixed episodes.  J Clin Psychiatry. 2004;  65 478-484
• 27 Weisler R H, Keck P E, Swann A C, Cutler A J, Ketter T A, Kalali A H. et al . Extended-release carbamazepine capsules as monotherapy for acute mania in bipolar disorder: a multicenter, randomized, double-blind, placebo-controlled trial.  J Clin Psychiatry. 2005;  66 (3) 323-330
• 28 Keck P EJ, McElroy S L. Outcome in the pharmacologic treatment of bipolar disorder.  J Clin Psychopharmacol. 1996;  16 (2, Suppl 1) 15S-23S
• 29 Emilien G, Maloteaux J M, Seghers A, Charles G. Lithium compared to valproic acid and carbamazepine in the treatment of mania: a statistical meta-analysis.  Eur Neuropsychopharmacol. 1996;  6 245-252
• 30 Post R M, Ketter T A, Denicoff K, Pazzaglia P J, Leverich G S, Marangell L B. et al . The place of anticonvulsant therapy in bipolar illness.  Psychopharmacology. 1996;  128 115-129
• 31 Hesslinger B, Normann C, Langosch J M, Klose P, Berger M, Walden J. Effects of carbamazepine and valproate on haloperidol plasma levels and on psychopathologic outcome in schizophrenic patients.  J Clin Psychopharmacol. 1999;  19 310-315
• 32 Mukherjee S, Rosen A M, Caracci G, Shukla S. Persistent tardive dyskinesia in bipolar patients.  Arch Gen Psychiatr. 1986;  43 (4) 342-346
• 33 Swann A C, Bowden C L, Calabrese J R, Dilsaver S C, Morris D D. Pattern of response to divalproex, lithium, or placebo in four naturalistic subtypes of mania.  Neuropsychopharmacology. 2002;  26 (4) 530-536
• 34 Secunda S K, Swann A, Katz M M, Koslow S H, Croughan J, Chang S. Diagnosis and treatment of mixed mania.  Am J Psychiatry. 1987;  144 (1) 96-98
• 35 Himmelhoch J M, Garfinkel M E. Sources of lithium resistance in mixed mania.  Psychopharmacology Bulletin. 1986;  22 (3) 613-620
• 36 Goldberg J F, Garno J L, Leon A C, Kocsis J H, Portera L. Rapid titration of mood stabilizers predicts remission from mixed or pure mania in bipolar patients [published erratum appears in J Clin Psychiatry 1998 Jun; 59 (6): 320].  J Clin Psychiatry. 1998;  59 (4) 151-158
• 37 Benabarre A, Vieta E, Colom F, Martinez A, Reinares M, Corbella B. Treatment of mixed mania with risperidone and mood stabilizers.  Can J Psychiatry. 2001;  46 (9) 866-867
• 38 Whitlock F A, Evans L E. Drugs and depression.  Drugs. 1978;  15 53-71
• 39 Coryell W, Leon A C, Turvey C, Akiskal H, Mueller T I, Endicott J. The significance of psychotic features in manic episodes: a report from the NIMH collaborative study.  J Affect Disord. 2001;  67 (1 - 3) 79-88
• 40 Johnstone E C, Crow T J, Frith C D, Owens D G. The Northwick Park „functional psychosis” study: diagnosis and treatment response.  Lancet. 1988;  2 119-125
• 41 Kusumakar V, Lakshmi N Y, Haslam D RS, Parikh S V, Matte R. Treatment of mania, mixed state and rapid cycling.  Canadian Journal of Psychiatry. 1997;  42 (Suppl 2) 79S-86S
• 42 McElroy S L, Keck P E, Stanton S P, Tugrul K C, Bennett J A, Strakowski S M. A randomized comparison of divalproex oral loading versus haloperidol in the initial treatment of acute psychotic mania.  J Clin Psychiatry. 1996;  57 (4) 142-146
• 43 Akiskal H. Dysthymia and cyclothymia in psychiatric practice a century after Kraepelin.  J Affect Disord. 2001;  62 31
• 44 Deltito J A. The effect of valproate on bipolar spectrum temperamental disorders.  J Clin Psychiatry. 1993;  54 300-304
• 45 Jacobsen F M. Low-dose valproate: a new treatment for cyclothymia, mild rapid cycling disorders and premenstrual syndrome.  J Clin Psychiatry. 1993;  54 229-234
• 46 Vieta E, Gasto C, Colom F, Reinares M, Martinez-Aran A, Benabarre A. et al . Role of risperidone in bipolar II: an open 6-month study.  J Affect Disord. 2001;  67 (1 - 3) 213-219
• 47 Amann B, Schlösser S, Sterr A, Hummel B, Schäfer M, Padovan C S. et al . Anticonvulsants in the treatment of aggression in the demented elderly.  Psychiatric Networks. 2000;  3 87-95
• 48 Small J G, Klapper M H, Kellams J J, Miller M J, Milstein V, Sharpley P H. et al . Electroconvulsive treatment compared with lithium in the management of manic states.  Arch Gen Psychiatry. 1988;  45 727-732
• 49 Black D W, Winokur G, Nasrallah A. Treatment of mania: a naturalistic study of electroconvulsive therapy versus lithium in 438 patients.  J Clin Psychiatry. 1987;  48 132-139
• 50 Mukherjee S, Sackeim H A, Schnur D B. Electroconvulsive therapy of acute manic episodes: a review of 50 years' experience.  Am J Psychiatry. 1994;  151 169-176