Antiprothrombin antibodies detected in two different assay systems

Maria Laura Bertolaccini; Tatsuya Atsumi; Takao Koike; Graham R. V. Hughes; Munther A. Khamashta

doi:10.1160/TH04-06-0382

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2005; 93(02): 289-297
DOI: 10.1160/TH04-06-0382

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Antiprothrombin antibodies detected in two different assay systems

Prevalence and clinical significance in systemic lupus erythematosus

Authors

Maria Laura Bertolaccini

¹Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK
Tatsuya Atsumi

²Internal Medicine II, Hokkaido University School of Medicine, Sapporo, Japan
Takao Koike

²Internal Medicine II, Hokkaido University School of Medicine, Sapporo, Japan
Graham R. V. Hughes

¹Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK
Munther A. Khamashta

¹Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK

Abstract

Summary

We evaluated the clinical significance of aPT and aPS-PT by testing for the presence of these antibodies in 212 SLE patients and in 100 healthy individuals. Results show that anti-prothrombin antibodies were found in 47% of the patients (aPT in 31% and aPS-PT in 31%). Their presence did not correlate with that of aCL, anti-β 2GPI, LA and/or anti-protein S. IgG but not IgM aPT were more frequently found in patients with thrombosis than in those without. IgG and IgM aPS-PT were also more frequent in patients with thrombosis (venous and/or arterial) than in those without. Levels of IgG aPT and IgG and IgM aPS-PT were higher in patients with thrombosis than in those without. Although aPT and aPS-PT were more frequently found in women with adverse obstetric history than in those without, the differences were not statistically significant. More significantly, 48% of the patients with aPL-related clinical features who were negative for standard tests had antiprothrombin antibodies. We can conclude that aPT and aPS-PT are frequently found in SLE. Their presence is associated with thrombosis, making these antibodies potential markers for the APS. Testing for these antibodies could be of clinical benefit in patients who are negative for the routinely used tests.

Keywords

Antiphospholipid syndrome - pregnancy morbidity - coagulation - thrombosis - lupus anticoagulant

Full Text

References

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