Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis

Erhard Hofer; Bernhard Schweighofer

doi:10.1160/TH06-08-0470

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 97(03): 355-363
DOI: 10.1160/TH06-08-0470

Theme Issue Article

Schattauer GmbH

Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis

Authors

Erhard Hofer

¹Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna. Austria
Bernhard Schweighofer

¹Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna. Austria

Abstract

Summary

New vessel formation during development and in the adult is triggered by concerted signals of largely endothelial-specific receptors for ligands of the VEGF, angiopoietin and ephrin families. The signals and genes induced by these receptors operate in the context of additional signals transduced by non-endothelial specific growth factor receptors, inflammatory cytokine receptors as well as adhesion molecules. We summarize here available data on characteristic signaling of the VEGF receptor-2 and the current state of knowledge regarding the additional different receptor tyrosine kinases of the VEGF, Tie and Ephrin receptor families. Furthermore, the potential cross-talk with signals induced by other growth factors and inflammatory cytokines as well as the modulation by VE-cadherin is discussed.

Keywords

Angiogenesis and inhibitors - signal transduction - endothelial cells

Full Text

References

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