Heyde’s syndrome without a decrease in large von Willebrand factor multimers: A case of intestinal bleedings reversed by valve replacement in a patient with aortic stenosis

Thromb Haemost 2009; 101(04): 773-774
DOI: 10.1160/TH08-07-0422

Case Report

Schattauer GmbH

Anetta Undas

¹Insitute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland

,

Jerzy Windyga

²Institute of Hematology and Transfusion Medicine, Warsaw, Poland

,

Ksenia Bykowska

²Institute of Hematology and Transfusion Medicine, Warsaw, Poland

,

Pawel P. Dimitrow

¹Insitute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland

,

Ewa Stepien

¹Insitute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland

,

Jerzy Sadowski

¹Insitute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland

References
1 Pate GE, Chandavind M, Naiman SC. et al. Heyde’s syndrome: review. J Heart Valve Dis 2004; 13: 701-712.
2 Warkentin TE, Moore JC, Morgan DG. Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand’s disease the link?. Lancet 1992; 340: 35-37.
3 Vincentelli A, Susen S, Le Tourneau T. et al. Acquired von Willebrand syndrome in aortic stenosis. N Engl J Med 2003; 349: 343-349.
4 Krizek DR, Rick ME. A rapid method to visualize von Willebrand factor multimers by using agarose gel electrophoresis, immunolocalization and lumino-graphic detection. Thromb Res 2000; 97: 457-462.
5 Makris M. Gastrointestinal bleeding in von Wille-brand disease. Thromb Res 2006; 118 (Suppl. 01) S13-S17.
6 Veyradier A, Fressinaud E, Meyer D. Laboratory diagnosis of von Willebrand disease. Int J Clin Lab Res 1998; 28: 201-210.