Integrating Genomic Resources with Electronic Health Records using the HL7 Infobutton Standard

Bret S.E. Heale; Casey Lynnette Overby; Guilherme Del Fiol; Wendy S. Rubinstein; Donna R. Maglott; Tristan H. Nelson; Aleksandar Milosavljevic; Christa L. Martin; Scott R. Goehringer; Robert R. Freimuth; Marc S. Williams

doi:10.4338/ACI-2016-04-RA-0058

Applied Clinical Informatics, Table of Contents

Appl Clin Inform 2016; 07(03): 817-831
DOI: 10.4338/ACI-2016-04-RA-0058

Research Article

Schattauer GmbH

Integrating Genomic Resources with Electronic Health Records using the HL7 Infobutton Standard

Authors

Bret S.E. Heale

¹University of Utah, Salt Lake City, Utah

⁷Intermountain Healthcare, Salt Lake City, UT
Casey Lynnette Overby

²Johns Hopkins University, Baltimore, MD

⁴Geisinger Health System, Danville, PA
Guilherme Del Fiol

¹University of Utah, Salt Lake City, Utah
Wendy S. Rubinstein

³National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD
Donna R. Maglott

³National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD
Tristan H. Nelson

⁴Geisinger Health System, Danville, PA
Aleksandar Milosavljevic

⁵Baylor College of Medicine, Houston, TX
Christa L. Martin

⁴Geisinger Health System, Danville, PA
Scott R. Goehringer

⁴Geisinger Health System, Danville, PA
Robert R. Freimuth

⁶Mayo Clinic, Rochester, MN
Marc S. Williams

⁴Geisinger Health System, Danville, PA

Abstract

Summary

Background

The Clinical Genome Resource (ClinGen) Electronic Health Record (EHR) Workgroup aims to integrate ClinGen resources with EHRs. A promising option to enable this integration is through the Health Level Seven (HL7) Infobutton Standard. EHR systems that are certified according to the US Meaningful Use program provide HL7-compliant infobutton capabilities, which can be leveraged to support clinical decision-making in genomics.

Objectives

To integrate genomic knowledge resources using the HL7 infobutton standard. Two tactics to achieve this objective were: (1) creating an HL7-compliant search interface for ClinGen, and (2) proposing guidance for genomic resources on achieving HL7 Infobutton standard accessibility and compliance.

Methods

We built a search interface utilizing OpenInfobutton, an open source reference implementation of the HL7 Infobutton standard. ClinGen resources were assessed for readiness towards HL7 compliance. Finally, based upon our experiences we provide recommendations for publishers seeking to achieve HL7 compliance.

Results

Eight genomic resources and two sub-resources were integrated with the ClinGen search engine via OpenInfobutton and the HL7 infobutton standard. Resources we assessed have varying levels of readiness towards HL7-compliance. Furthermore, we found that adoption of standard terminologies used by EHR systems is the main gap to achieve compliance.

Conclusion

Genomic resources can be integrated with EHR systems via the HL7 Infobutton standard using OpenInfobutton. Full compliance of genomic resources with the Infobutton standard would further enhance interoperability with EHR systems.

Citation: Heale BSE, Overby CL, Del Fiol G, Rubinstein WS, Maglott DR, Nelson TH, Milosavljevic A, Martin CL, Goehringer SR, Freimuth RR, Williams MS. Integrating genomic resources with electronic health records using the HL7 Infobutton standard.

Keywords

Clinical information systems - standards adoption - HL7 - genetics - clinical decision support

Full Text

References

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