Harder, Yves et al.: 2024 Modern Surgical Management of Chronic Lymphedema DOI: 10.1055/b-0044-201951
Section VIII: Training, Treatment Algorithm, Outcomes, and Further Developments

19 Review of the Current Literature

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Editors: Harder, Yves; Hirche, Christoph; Seidenstücker, Katrin; Hamdi, Moustapha

Authors: Adriaenssens, Nele; Baumeister, Rüdiger G. H.; Bianchi, Alessandro; Bigdeli, Amir K.; Boos, Anja M.; Bourgeois, Pierre; Brorson, Hakan; Brussaard, Carola; Cordts, Tomke; De Baerdemaeker, Randy; Engel, Holger; Frick, Andreas; Früh, Florian; Gazyakan, Emre; Goss, Jeremy A.; Gousopoulos, Epameinondas; Greene, Arin K.; Harnie, Sarah; Hartiala, Pauliina; Hayashi, Akitatsu; Kilian, Katja; Kumar, Leela Praveen; Kwak, Min-Seok; Lindenblatt, Nicole; Machens, Hans-Günther; Manokaran, Gurusamy; Masia, Jaume; Meroni, Matteo; Penna, Vincenzo; Pieper, Claus Christian; Pomata, Cristhian; Rodríguez-Bauzà, Elena; Roka-Palkovits, Julia; Saaristo, Anne; Salgarello, Marzia; Scaglioni, Mario F.; Schild, Hans Heinz; Spörlein, Andreas; Stäuble, Christiane G.; Suami, Hiroo; Torio, Nestor; Tzou, Chieh-Han; Uyulmaz, Semra; Vandyck, Ellen; Visconti, Giuseppe; Visuri, Mikko; Wagner, Stephan; Waked, Karl; Will, Patrick A.; Wilting, Jörg; Yang, Johnson Chia-Shen; Zeltzer MD, Assaf; Zuther, Joachim E.

Title: Modern Surgical Management of Chronic Lymphedema

Print ISBN: 9783132414280; Online ISBN: 9783132436855; Book DOI: 10.1055/b000000221

Subjects: Plastic, Reconstructive and Cosmetic Surgery

Thieme Clinical Collections (English Language)



 
Mario F. Scaglioni and Matteo Meroni

Summary

This chapter will highlight the current scientific evidence available that describes the different surgical procedures to be used to treat lymphedema. Since comparative studies are still infrequent, most studies available nowadays are more or less big case series and expert opinion based on personal experience and, therefore, the level of evidence is rather low. Yet, over the last years, the surgical management of lymphedema has undergone a true revival, particularly with regard to reconstructive microsurgery and therefore resulted in a continuous increase in scientific evidence. This chapter summarizes the current state of pre-, intra-, and postoperative visualization and monitoring of the lymphatic vascular system. Further, it highlights the currently used surgical procedures, both when offering lymphoablative surgery and reconstructive surgery, as a standalone procedure or in combination. It also highlights reconstructive surgery in a prophylactic setting, i.e., while performing lymph node dissection during oncological surgery, and finally describes potential therapeutical approaches based on scientific consensus.

 
  • 1 Scaglioni MF, Arvanitakis M, Chen YC, Giovanoli P, Chia-Shen Yang J, Chang EI. Comprehensive review of vascularized lymph node transfers for lymphedema: outcomes and complications.. Microsurgery 2018; 38 (2) 222-229 PubMed (PMID: 27270748)
  • 2 Charles H. Elephantiasis of the leg. In: Latham A, English TC, eds. A System of Treatment. Vol. 3. London: Churchill; 1912
  • 3 Brorson H. Liposuction normalizes lymphedema induced adipose tissue hypertrophy in elephantiasis of the leg—a prospective study with a ten-year follow-up.. Plast Reconstr Surg 2015; 136 (4) (Suppl. Suppl) 133-134 (PMID: NOT_FOUND)
  • 4 Brorson H. Complete reduction of arm lymphedema following breast cancer—a prospective twenty-one years’ study.. Plast Reconstr Surg 2015; 136 (4) (Suppl. Suppl) 134-135 (PMID: NOT_FOUND)
  • 5 Danese C, Bower R, Howard J. Experimental anastomoses of lymphatics.. Arch Surg 1962; 84: 6-9. Discussion following PubMed (PMID: 13883364)
  • 6 Yamamoto T, Yoshimatsu H, Koshima I. Navigation lymphatic supermicrosurgery for iatrogenic lymphorrhea: supermicrosurgical lymphaticolymphatic anastomosis and lymphaticovenular anastomosis under indocyanine green lymphography navigation.. J Plast Reconstr Aesthet Surg 2014; 67 (11) 1573-1579 PubMed (PMID: 25023202)
  • 7 Li K, Zhang Z, Nicoli F et al. Application of indocyanine green in flap surgery: a systematic review.. J Reconstr Microsurg 2018; 34 (2) 77-86 PubMed (PMID: 28992648)
  • 8 Saaristo AM, Niemi TS, Viitanen TP, Tervala TV, Hartiala P, Suominen EA. Microvascular breast reconstruction and lymph node transfer for postmastectomy lymphedema patients.. Ann Surg 2012; 255 (3) 468-473 PubMed (PMID: 22233832)
  • 9 Scaglioni MF, Suami H. Lymphatic anatomy of the inguinal region in aid of vascularized lymph node flap harvesting.. J Plast Reconstr Aesthet Surg 2015; 68 (3) 419-427 PubMed (PMID: 25465766)
  • 10 Agko M, Ciudad P, Chen HC. Staged surgical treatment of extremity lymphedema with dual gastroepiploic vascularized lymph node transfers followed by suction-assisted lipectomy—a prospective study.. J Surg Oncol 2018; 117 (6) 1148-1156 PubMed (PMID: 29355987)
  • 11 Sedlácek J. Lymphovenous shunt as supplementary treatment of elephantiasis of lower limbs.. Acta Chir Plast 1969; 11 (2) 157-162 PubMed (PMID: 4184616)
  • 12 Chang EI, Skoracki RJ, Chang DW. Lymphovenous anastomosis bypass surgery.. Semin Plast Surg 2018; 32 (1) 22-27 PubMed (PMID: 29636650)
  • 13 Scaglioni MF, Fontein DBY, Arvanitakis M, Giovanoli P. Systematic review of lymphovenous anastomosis (LVA) for the treatment of lymphedema.. Microsurgery 2017; 37 (8) 947-953 PubMed (PMID: 28972280)
  • 14 Chang DW, Suami H, Skoracki R. A prospective analysis of 100 consecutive lymphovenous bypass cases for treatment of extremity lymphedema.. Plast Reconstr Surg 2013; 132 (5) 1305-1314 PubMed (PMID: 24165613)
  • 15 Hara H, Mihara M, Ohtsu H, Narushima M, Iida T, Koshima I. Indication of lymphaticovenous anastomosis for lower limb primary lymphedema.. Plast Reconstr Surg 2015; 136 (4) 883-893 PubMed (PMID: 26086382)
  • 16 Suami H, Scaglioni MF, Dixon KA, Tailor RC. Interaction between vascularized lymph node transfer and recipient lymphatics after lymph node dissection—a pilot study in a canine model.. J Surg Res 2016; 204 (2) 418-427 PubMed (PMID: 27565078)
  • 17 Cheng MH, Chen SC, Henry SL, Tan BK, Chia-Yu Lin M, Huang JJ. Vascularized groin lymph node flap transfer for postmastectomy upper limb lymphedema: flap anatomy, recipient sites, and outcomes.. Plast Reconstr Surg 2013; 131 (6) 1286-1298 PubMed (PMID: 23714790)
  • 18 Ciudad P, Manrique OJ, Bustos SS et al. Comparisons in long-term clinical outcomes among patients with upper or lower extremity lymphedema treated with diverse vascularized lymph node transfer.. Microsurgery 2020; 40 (2) 130-136 PubMed (PMID: 31489971)
  • 19 Chen WF, McNurlen M, Ding J, Bowen M. Vascularized lymph vessel transfer for extremity lymphedema—is transfer of lymph node still necessary?. Int Microsurg J 2019; 3 (3) 1 (PMID: 31489971)
  • 20 Raju A, Chang DW. Vascularized lymph node transfer for treatment of lymphedema: a comprehensive literature review.. Ann Surg 2015; 261 (5) 1013-1023 PubMed (PMID: 24950271)
  • 21 Nguyen AT, Chang EI, Suami H, Chang DW. An algorithmic approach to simultaneous vascularized lymph node transfer with microvascular breast reconstruction.. Ann Surg Oncol 2015; 22 (9) 2919-2924 PubMed (PMID: 25623599)
  • 22 Granzow JW, Soderberg JM, Kaji AH, Dauphine C. An effective system of surgical treatment of lymphedema.. Ann Surg Oncol 2014; 21 (4) 1189-1194 PubMed (PMID: 24522988)
  • 23 Di Taranto G, Bolletta A, Chen SH et al. A prospective study on combined lymphedema surgery: gastroepiploic vascularized lymph nodes transfer and lymphaticovenous anastomosis followed by suction lipectomy.. Microsurgery 2021; 41 (1) 34-43 PubMed (PMID: 32845534)
  • 24 Carl HM, Walia G, Bello R et al. Systematic review of the surgical treatment of extremity lymphedema.. J Reconstr Microsurg 2017; 33 (6) 412-425 PubMed (PMID: 28235214)
  • 25 Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J. Methodological index for non-randomized studies (minors): development and validation of a new instrument.. ANZ J Surg 2003; 73 (9) 712-716 PubMed (PMID: 12956787)
  • 26 Boccardo F, Casabona F, De Cian F et al. Lymphedema microsurgical preventive healing approach: a new technique for primary prevention of arm lymphedema after mastectomy.. Ann Surg Oncol 2009; 16 (3) 703-708 PubMed (PMID: 19139964)
  • 27 Boccardo F, De Cian F, Campisi CC et al. Surgical prevention and treatment of lymphedema after lymph node dissection in patients with cutaneous melanoma.. Lymphology 2013; 46 (1) 20-26 PubMed (PMID: 23930438)
  • 28 Feldman S, Bansil H, Ascherman J et al. Single institution experience with lymphatic microsurgical preventive healing approach (LYMPHA) for the primary prevention of lymphedema.. Ann Surg Oncol 2015; 22 (10) 3296-3301 PubMed (PMID: 26202566)
  • 29 Ozmen T, Lazaro M, Zhou Y, Vinyard A, Avisar E. Evaluation of simplified lymphatic microsurgical preventing healing approach (S-LYMPHA) for the prevention of breast cancer-related clinical lymphedema after axillary lymph node dissection.. Ann Surg 2019; 270 (6) 1156-1160 PubMed (PMID: 29794843)
  • 30 . The diagnosis and treatment of peripheral lymphedema: 2013 Consensus Document of the International Society of Lymphology.. Lymphology 2013; 46 (1) 1-11 PubMed (PMID: 23930436)
  • 31 Campisi C, Boccardo F, Zilli A, Macciò A, Napoli F. Long-term results after lymphatic-venous anastomoses for the treatment of obstructive lymphedema.. Microsurgery 2001; 21 (4) 135-139 PubMed (PMID: 11494379)
  • 32 Hirche C, Engel H, Seidenstuecker K et al. Rekonstruktive Mikrochirurgie des sekundären Lymphödems: Konsensus der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der peripheren Nerven und Gefäße (DAM) zur Indikation, Diagnostik und Therapie mittels Lymphovenöser Anastomosen (LVA) und vaskularisierter Lymphknotentransplantation (VLKT). [Lympho-reconstructive microsurgery for secondary lymphedema: Consensus of the German-Speaking Society for Microsurgery of Peripheral Nerves and Vessels (DAM) on indication, diagnostic and therapy by lymphovenous anastomosis (LVA) and vascularized lymph node transfer (VLNT)].. Handchir Mikrochir Plast Chir 2019; 51 (6) 424-433 PubMed (PMID: 31067594)
  • 33 Beederman M, Garza RM, Agarwal S, Chang DW. Outcomes for physiologic microsurgical treatment of secondary lymphedema involving the extremity.. Ann Surg 2020.; PubMed 10.1097/SLA.0000000000004457(PMID: 32889875)
  • 34 Grünherz L, Hulla H, Uyulmaz S, Giovanoli P, Lindenblatt N. Patient-reported outcomes following lymph reconstructive surgery in lower limb lymphedema: a systematic review of literature.. J Vasc 2021; 9 (3) 811-819.e2 PubMed (PMID: 33309902)