1.6. 1 Glycosidases and Glycosynthases
Buch
Herausgeber: Faber, K.; Fessner, W.-D.; Turner, N. J.
Titel: Biocatalysis in Organic Synthesis 1
Print ISBN: 9783131741318; Online ISBN: 9783131975218; Buch-DOI: 10.1055/b-003-125815
1st edition © 2015. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Fachgebiete: Organische Chemie
Science of Synthesis Reference Libraries
Übergeordnete Publikation
Titel: Science of Synthesis
DOI: 10.1055/b-00000101
Typ: Mehrbändiges Werk
Abstract
Enzymatic synthesis of glycans, as an alternative to classical chemical synthesis, is of great interest due to the exquisite stereospecificity and improved processivity and regioselectivity of the biological catalysts, and for the possibility of using reagents less toxic to the environment. Nonetheless, the limitations intrinsic to the natural enzymes promoting sugar synthesis, namely glycoside hydrolases and glycosyltransferases, have prompted efforts to engineer the former catalysts, obtaining glycosynthases that promote the synthesis of oligosaccharides, polysaccharides, and glycoconjugates in quantitative yields from inexpensive substrates. In this chapter we survey methods that exploit glycosidases and glycosynthases to allow the efficient and reliable preparation of glycans of synthetic relevance.
Schlüsselwörter
carbohydrate active enzymes - carbohydrate synthesis - enzyme engineering - glycobiology - glycochemistry - glycoconjugates - glycosidase reaction mechanism - glycosyltransferase - oligosaccharides - polysaccharides - protein glycosylation-
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