1.2 Cation–π Cyclizations of Epoxides and Polyepoxides

K. W. Armbrust; T. Halkina; E. H. Kelley; S. Sittihan; T. Jamison

Abstract

This chapter describes the formation of complex polycyclic fragments from linear epoxide and polyepoxide precursors via domino reactions. Depending on the reaction conditions employed, either exo or endo epoxide opening can be selectively achieved. Applications of these domino reactions toward the synthesis of complex natural products are discussed.

Schlüsselwörter

oxiranes - cascades - natural products - marine ladder polyethers - ionophores - ethers - oxygen heterocycles - tetrahydrofurans - tetrahydropyrans - oxepanes

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