2.6 Metal-Catalyzed (2 + 2 + 2) Cycloadditions
Book
Editors: Gao, S.; Ma, S.
Title: Metal-Catalyzed Cyclization Reactions 2
Print ISBN: 9783131998118; Online ISBN: 9783132404823; Book DOI: 10.1055/b-004-129734
1st edition © 2016 Georg Thieme Verlag KG
Georg Thieme Verlag, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Carreira, E. M.; Decicco, C. P.; Fürstner, A.; Koch, G.; Molander, G.; Schaumann, E.; Shibasaki, M.; Thomas, E. J.; Trost, B. M.
Type: Multivolume Edition
Abstract
The transition-metal-catalyzed (2 + 2 + 2) cycloaddition is a useful and atom-economical method for the synthesis of substituted six-membered-ring molecules. In this chapter, standard procedures for the transition-metal-catalyzed (2 + 2 + 2) cycloaddition involving not only alkynes but also nitriles, heterocumulenes, alkenes, and carbonyl compounds are presented. Applications in the synthesis of chiral aromatic molecules (biaryls, cyclophanes, and helicenes) and biologically active molecules are also described.
Key words
alkenes - alkynes - asymmetric catalysis - benzenes - biaryls - carbocycles - carbodiimides - carbon dioxide - carbonyl compounds - cycloaddition - cyclophanes - helicenes - heterocumulenes - heterocycles - isocyanates - metallacycles - nitriles - pyridines - pyridones - transition metals-
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