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Bäckvall, J.-E. : 2023 Science of Synthesis, 2022/4: Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT) DOI: 10.1055/sos-SD-237-00100
Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT)

8 Chemoenzymatic Dynamic Kinetic Asymmetric Transformation

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Editor: Bäckvall, J.-E. 

Authors: Adriaensen, K. ; Akai, S. ; Berreur, J. ; Bhat, V. ; Clayden, J. ; Collins, B. S. L. ; Córdova, A. ; De Vos, D. ; Deiana, L.; Faber, K. ; Fletcher, S. P. ; Goetzke, F. W. ; González-Granda, S. ; Gotor-Fernández, V. ; Hafeman, N. J. ; Jin, Z. ; Kanomata, K. ; Kroutil, W. ; Liu, Y.; Modicom, F.; Pàmies, O. ; Sardini, Jr., S. R.; Stoltz, B. M. ; Winkler, C. K. ; Wu, X. ; Xie, J.-H. ; Zhang, K.; Zhou, Q.-L. 

Title: Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT)

Print ISBN: 9783132453777; Online ISBN: 9783132453791; Book DOI: 10.1055/b000000439

2023 © 2023. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart

Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry

Science of Synthesis Reference Libraries



Parent publication

Title: Science of Synthesis

DOI: 10.1055/b-00000101

Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.

Type: Multivolume Edition

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Abstract

The combination of enzymes and metal complexes can be used to achieve the de-epimerization of diastereoisomeric mixtures. Thus, by means of this chemoenzymatic dynamic kinetic asymmetric transformation (DYKAT), a wide range of racemic diols and, to a lesser extent, amino alcohols and diamines, have been transformed into a single diastereoisomer in excellent yields, and diastereo- and enantioselectivities.

Key words

dynamic kinetic asymmetric transformation - DYKAT - enzymes - metal complexes - diols - amino alcohols - diamines - chirality
 
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