8 Chemoenzymatic Dynamic Kinetic Asymmetric Transformation
Buch
Herausgeber: Bäckvall, J.-E.
Titel: Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT)
Print ISBN: 9783132453777; Online ISBN: 9783132453791; Buch-DOI: 10.1055/b000000439
1st edition © 2023. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Fachgebiete: Organische Chemie;Chemische Reaktionen, Katalyse;Organometallchemie;Chemische Labormethoden, Stöchiometrie
Science of Synthesis Reference Libraries
Übergeordnete Publikation
Titel: Science of Synthesis
DOI: 10.1055/b-00000101
Reihenherausgeber: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Typ: Mehrbändiges Werk
Abstract
The combination of enzymes and metal complexes can be used to achieve the de-epimerization of diastereoisomeric mixtures. Thus, by means of this chemoenzymatic dynamic kinetic asymmetric transformation (DYKAT), a wide range of racemic diols and, to a lesser extent, amino alcohols and diamines, have been transformed into a single diastereoisomer in excellent yields, and diastereo- and enantioselectivities.