3.2. 2.3 DNA-Encoded Dynamic Combinatorial Chemical Libraries
Book
Editors: Scheuermann, J. ; Li, Y.
Title: DNA-Encoded Libraries
Print ISBN: 9783132455221; Online ISBN: 9783132437357; Book DOI: 10.1055/b000000342
1st edition © 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG, Stuttgart
Subjects: Organic Chemistry;Chemical Reactions, Catalysis;Organometallic Chemistry;Laboratory Techniques, Stoichiometry
Science of Synthesis Reference Libraries
Parent publication
Title: Science of Synthesis
DOI: 10.1055/b-00000101
Series Editors: Fürstner, A. (Editor-in-Chief); Carreira, E. M.; Faul, M.; Kobayashi, S.; Koch, G.; Molander, G. A.; Nevado, C.; Trost, B. M.; You, S.-L.
Type: Multivolume Edition
Abstract

DNA-encoded dynamic combinatorial chemical library (EDCCL) technology is the application of dynamic combinatorial chemistry (DCC) in the field of DNA-encoded library (DEL) technology. EDCCL technology can be used for de novo selection as well as to convert lead compounds into high-affinity bivalent binders. EDCCL technology aims to combine the advantages of DCC and DEL, while addressing some drawbacks from both.
Key words
DNA-encoded libraries - dynamic combinatorial chemistry (DCC) - fragment-based drug discovery - chelate effect - dual pharmacophores- 1 Corbett PT, Leclaire J, Vial L, West KR, Wietor J.-L, Sanders JKM, Otto S. Chem. Rev. 2006; 106: 3652
- 6 Mocharla VP, Colasson B, Lee LV, Röper S, Sharpless KB, Wong C.-H, Kolb HC. Angew. Chem. Int. Ed. 2005; 44: 116
- 9 Buller F, Steiner M, Scheuermann J, Mannocci L, Nissen I, Kohler M, Beisel C, Neri D. Bioorg. Med. Chem. Lett. 2010; 20: 4188
- 12 Harris PA, King BW, Bandyopadhyay D, Berger SB, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Finger JN, Grady LC, Hoffman SJ, Jeong JU, Kang J, Kasparcova V, Lakdawala AS, Lehr R, McNulty DE, Nagilla R, Ouellette MT, Pao CS, Rendina AR, Schaeffer MC, Summerfield JD, Swift BA, Totoritis RD, Ward P, Zhang A, Zhang D, Marquis RW, Bertin J, Gough PJ. J. Med. Chem. 2016; 59: 2163
- 13 Fernández-Montalván AE, Berger M, Kuropka B, Koo SJ, Badock V, Weiske J, Puetter V, Holton SJ, Stöckigt D, ter Laak A, Centrella PA, Clark MA, Dumelin CE, Sigel EA, Soutter HH, Troast DM, Zhang Y, Cuozzo JW, Keefe AD, Roche D, Rodeschini V, Chaikuad A, Díaz-Sáez L, Bennett JM, Fedorov O, Huber KVM, Hübner J, Weinmann H, Hartung IV, Gorjánácz M. ACS Chem. Biol. 2017; 12: 2730
- 14 Clark MA, Acharya RA, Arico-Muendel CC, Belyanskaya SL, Benjamin DR, Carlson NR, Centrella PA, Chiu CH, Creaser SP, Cuozzo JW, Davie CP, Ding Y, Franklin GJ, Franzen KD, Gefter ML, Hale SP, Hansen NJV, Israel DI, Jiang J, Kavarana MJ, Kelley MS, Kollmann CS, Li F, Lind K, Mataruse S, Medeiros PF, Messer JA, Myers P, OʼKeefe H, Oliff MC, Rise CE, Satz AL, Skinner SR, Svendsen JL, Tang L, van Vloten K, Wagner RW, Yao G, Zhao B, Morgan BA. Nat. Chem. Biol. 2009; 5: 647
- 18 Wichert M, Krall N, Decurtins W, Franzini RM, Pretto F, Schneider P, Neri D, Scheuermann J. Nat. Chem. 2015; 7: 241
- 21 Reddavide FV, Cui M, Lin W, Fu N, Heiden S, Andrade H, Thompson M, Zhang Y. Chem. Commun. (Cambridge) 2019; 55: 3753
- 22 Zhou Y, Li C, Peng J, Xie L, Meng L, Li Q, Zhang J, Li XD, Li X, Huang X, Li X. J. Am. Chem. Soc. 2018; 140: 15859
- 25 Hartman MR, Yang D, Tran TNN, Lee K, Kahn JS, Kiatwuthinon P, Yancey KG, Trotsenko O, Minko S, Luo D. Angew. Chem. Int. Ed. 2013; 52: 8699
- 27 Grünzner S, Reddavide FV, Steinfelder C, Cui M, Busek M, Klotzbach U, Zhang Y, Sonntag F, Gray BL, Becker H. 10061 Microfluidics, BioMEMS, and Medical Microsystems XV 2017; 1006111 https://doi.org/10.1117/12.2253840