Histologic and Biomechanical Evaluation of the Effects of Social Stress and the Antidepressant Fluoxetine on Tendon Healing in Rats

Muhammed Besir Ozturk; Onur Egemen; Salih Onur Basat; Ergün Bozdağ; Damlanur Sakız; Mithat Akan

doi:10.1007/s12593-015-0204-4

Journal of Hand and Microsurgery, Table of Contents

J Hand Microsurg 2015; 07(02): 294-299
DOI: 10.1007/s12593-015-0204-4

Original Article

Thieme Medical and Scientific Publishers Private Ltd.

Histologic and Biomechanical Evaluation of the Effects of Social Stress and the Antidepressant Fluoxetine on Tendon Healing in Rats

Muhammed Besir Ozturk

¹Department of Plastic Reconstructive and Aesthetic Surgery, Tekirdağ Government Hospital, Tekirdağ, Turkey Email: muhammedozturk@msn.com

,

Onur Egemen

²Department of Plastic Reconstructive and Aesthetic Surgery, Liv Hospital, İstanbul, Turkey

,

Salih Onur Basat

³Department of Plastic Reconstructive and Aesthetic Surgery, Bağcılar Training and Research Hospital, İstanbul, Turkey

,

Ergün Bozdağ

⁴Faculty of Mechanical Engineering, Labaratory of Strength of Materials and Biomechanics, Istanbul Technical University, İstanbul, Turkey

,

Damlanur Sakız

⁵Department of Pathology, Şişli Etfal Training and Research Hospital, İstanbul, Turkey

,

Mithat Akan

⁶Department of Plastic Reconstructive and Aesthetic Surgery, Medipol University Hospital, İstanbul, Turkey

› Author Affiliations
Subject Editor:

Abstract

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Abstract

Impaired wound healing in humans under psychological stress and the positive effects of antidepressant drugs on wound healing were also shown in the literature. However, there are currently no studies regarding the effects of antidepressant drugs on tendon healing. The aim of this study was to compare tendon healing under normal conditions versus social stress. We also aimed to perform a histological and biomechanical analysis of the effects of the antidepressant drug fluoxetine on tendon healing. Sixty Sprague Dawley rats were divided into six groups. A social stress regimen was used to stress the rats. The use of fluoxetine in the social stress group yielded significantly better biomechanical results and the collagen organizations of the fluoxetine group were more similar to the normal tendon collagen organization. Fluoxetine seems to inhibit the negative effects of stress on tendon healing and seems to improve tendon healing.

Levels of Evidence: Level 5

Keywords

Social stress - Fluoxetine - Tendon healing - Social stress and tendon healing - SSRI and tendon healing

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References

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