Homeopathy 2009; 98(03): 137-141
DOI: 10.1016/j.homp.2009.05.006
Original Paper
Copyright © The Faculty of Homeopathy 2009

Homeopathic treatment of minor aphthous ulcer: a randomized, placebo-controlled clinical trial

Fahimeh Mousavi
Yalda Nozad Mojaver
Mehdi Asadzadeh
Mustafa Mirzazadeh

Subject Editor:
Further Information

Publication History

Received15 December 2008
revised17 May 2009

accepted27 May 2009

Publication Date:
20 December 2017 (online)

Objective: The objectives of this study were to clinically determine the efficacy of individualised homeopathy in the treatment of minor recurrent aphthous ulceration (MiRAU).

Design & intervention: A randomized, single blind, placebo-controlled clinical trial of individualised homeopathy. One hundred patients with minor aphthous ulcer were treated with individualised homeopathic medicines or placebo and followed up for 6 days. Patients received two doses of individualised homeopathic medicines in the 6C potency as oral liquid at baseline and 12 h later. Pain intensity and ulcer size were recorded at baseline during and at the end of the trial (mornings of days 4 and 6).

Result: All 100 patients completed treatment. Between group differences for pain intensity and ulcer size were statistically significant at day 4 and at day 6 (P < 0.05). No adverse effects were reported.

Conclusion: The results suggest that homeopathic treatment is an effective and safe method in the treatment of MiRAU.

  • References

  • 1 Clover Ann. Homeopathy. UK: Victoria, 1999, p. 89–93.
  • 2 Akintoye S.O., Greenberg M.S. Recurrent aphthous stomatitis. Dent Clin North Am 2005; 49 (01) 31-47 vii–viii
  • 3 Ship J.A. Recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 81 (02) 141-147.
  • 4 Rogers 3rd R.S. Recurrent aphthous stomatitis, clinical characteristics and associated system disorders. Semin Cutan Med Surg 1997; 16 (04) 278-283.
  • 5 Volkov I., Rudoy I., Freud T. et al. Effectiveness of vitamin B12 in treating recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled trial. J Am Board Fam Med 2009; 22 (01) 9-16.
  • 6 Scully C. The oral cavity and lips. Burns T., Breathnach S., Cox N., Griffiths C. Rook's Textbook of Dermatology. 7th edn. 2004. Massachusetts, Oxford, Australia: Blakwell Science; 43-46 66
  • 7 Visual analogue scale. www.blackwellpublishing.com/specialarticles/jcn_10_706.pdf
  • 8 Liu Jie, Zeng Xin, Chen Qianming. An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102: 475-481.
  • 9 Altenburg A., Abdel-Naser M.B., Seeber H. Practical aspects of management of recurrent aphthous stomatitis. JEADV 2007; 21: 1019-1026.
  • 10 Fontes V., Machet L., Huttenberger B., Lorette G., Vaillant L. Recurrent aphthous stomatitis: treatment with colchicine. An open trial of 54 cases. Ann Dermatol Venereol 2002; 129: 1365-1369.
  • 11 Garcia Callejo F.J., Orts Alborch M.H., Molrant Ventura A., Segarra Cortes P., Marco Algarra J. Recurrent aphthous stomatitis and clinical response to pentoxifylline. Acta Otorrinolaringol Esp 1999; 50: 671-673.
  • 12 Chandrasekhar J., Liem A.A., Cox N.H., Paterson A.W. Oxypentoxifylline in the management of recurrent aphthous oral ulcers: an open clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999; 87: 564-567.
  • 13 Barrons R.W. Treatment strategies for recurrent oral aphthous ulcers. Am J Health Syst Pharm 2001; 58: 41-50.
  • 14 Porter S.R., Al-Johani K., Fedele S., Moles D.R. Randomised controlled trial of the efficacy of HybenX in the symptomatic treatment of recurrent aphthous stomatitis. Oral Dis 2009 Mar; 15 (02) 155-161.
  • 15 Babaee N., Mansourian A., Momen-Heravi F., Moghadamnia A. Momen-Beitollahi. The efficacy of a paste containing Myrtus communis (Myrtle) in the management of recurrent aphthous stomatitis: a randomized controlled trial. Clin Oral Investig 2009 Mar 21;