Homeopathy 2010; 99(01): 25-36
DOI: 10.1016/j.homp.2009.11.008
Original Paper
Copyright © The Faculty of Homeopathy 2009

Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study

PC. Endler
1  Interuniversity College for Health and Development Graz/Castle of Seggau, Austria
,
K. Thieves
1  Interuniversity College for Health and Development Graz/Castle of Seggau, Austria
,
C. Reich
1  Interuniversity College for Health and Development Graz/Castle of Seggau, Austria
,
P. Matthiessen
2  Centre for Integrative Medicine, University of Witten/Herdecke, Germany
,
L. Bonamin
3  Universidade Paulista, Sao Paulo, Brazil
,
C. Scherr
4  Hiscia Institute, Society for Cancer Research, Arlesheim, Switzerland
,
S. Baumgartner
4  Hiscia Institute, Society for Cancer Research, Arlesheim, Switzerland
5  Institute of Complementary Medicine KIKOM, University of Bern, Switzerland
› Author Affiliations

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Further Information

Publication History

Publication Date:
22 December 2017 (online)

Introduction: Repeatability of experiments is an important criterion of modern research and a major challenge for homeopathic basic research. There is no recent overview about basic research studies in high homeopathic potencies that have been subjected to laboratory-internal, multicenter or independent repetition trials.

Methods: We considered biochemical, immunological, botanical, cell biological and zoological studies on high potencies, i.e. beyond a dilution of 10-23. Main sources of information were reviews, personal contact with members of the homeopathic basic research community, and the MEDLINE and HOMBREX databases. Studies were extracted from the publications and grouped into models. Studies were further sorted according to repetition type (laboratory-internal, multicenter, or independent) and results achieved.

Results: A total of 107 studies were found. Of these, 30 were initial studies. In the attempt to reproduce one of these initial studies, 53 follow-up studies yielded comparable effects (35 laboratory-internal, 8 multicenter, 10 independent repetitions), eight studies showed a consistent, yet different result from the initial study (2 laboratory-internal, 2 multicenter, 4 independent repetitions), and 16 studies yielded no effects (5 laboratory-internal, 2 multicenter, 9 independent repetitions). When all repetitive studies are considered, 69% reported effects comparable to that of the initial study, 10% different effects, and 21% no effects. Independently performed repetition studies reported 44% comparable effects, 17% different effects, and 39% no effects.

Conclusions: We identified 24 experimental models in basic research on high homeopathic potencies, which were repeatedly investigated. 22 models were reproduced with comparable results, 6 models with different results, and repetition showed no results for 15 models. Independent reproductions with either comparable or different results were found for seven models. We encourage further repetition trials of published studies, in order to learn more about the model systems used and in order to test their repeatability.