Homeopathy 2013; 102(02): 130-138
DOI: 10.1016/j.homp.2013.02.004
Original Paper
Copyright © The Faculty of Homeopathy 2013

A prospective multi-centric open clinical trial of homeopathy in diabetic distal symmetric polyneuropathy

Chaturbhuja Nayak
1   Central Council for Research in Homoeopathy, New Delhi, India
Praveen Oberai
1   Central Council for Research in Homoeopathy, New Delhi, India
Roja Varanasi
1   Central Council for Research in Homoeopathy, New Delhi, India
Hafeezullah Baig
2   Drug Standardisation Unit (Homoeopathy), Hyderabad, India
Raveender Ch
3   Regional Research Institute (Homoeopathy), Gudivada, India
G.R.C. Reddy
4   Clinical Research Unit (Homoeopathy), Tirupati, India
Pratima Devi
5   Regional Research Institute (Homoeopathy), Guwahati, India
S Bhubaneshwari
6   Clinical Research Unit (Homoeopathy), Puducherry, India
Vikram Singh
1   Central Council for Research in Homoeopathy, New Delhi, India
V.P. Singh
1   Central Council for Research in Homoeopathy, New Delhi, India
Hari Singh
1   Central Council for Research in Homoeopathy, New Delhi, India
Shashi Shekhar Shitanshu
1   Central Council for Research in Homoeopathy, New Delhi, India
› Author Affiliations

Subject Editor:
Further Information

Publication History

Received28 September 2010
revised24 January 2013

accepted05 February 2013

Publication Date:
27 December 2017 (online)

Objectives: To evaluate homeopathic treatment in the management of diabetic distal symmetric polyneuropathy.

Methods: A prospective multi-centric clinical observational study was carried out from October 2005 to September 2009 by Central Council for Research in Homeopathy (CCRH) (India) at its five Institutes/Units. Patients suffering from diabetes mellitus (DM) and presenting with symptoms of diabetic polyneuropathy (DPN) were screened, investigated and were enrolled in the study after fulfilling the inclusion and exclusion criteria. Patients were evaluated by the Diabetic Distal Symmetric Polyneuropathy Symptom Score (DDSPSS) developed by the Council. A total of 15 homeopathic medicines were identified after repertorizing the nosological symptoms and signs of the disease. The appropriate constitutional medicine was selected and prescribed in 30, 200 and 1 M potency on an individualized basis. Patients were followed up regularly for 12 months.

Results: Out of 336 patients (167 males and 169 females) enrolled in the study, 247 patients (123 males and 124 females) were analyzed. All patients who attended at least three follow-up appointments and baseline curve conduction studies were included in the analysis.). A statistically significant improvement in DDSPSS total score (p = 0.0001) was found at 12 months from baseline. Most objective measures did not show significant improvement. Lycopodium clavatum (n = 132), Phosphorus (n = 27) and Sulphur (n = 26) were the medicines most frequently prescribed. Adverse event of hypoglycaemia was observed in one patient only.

Conclusion: This study suggests homeopathic medicines may be effective in managing the symptoms of DPN patients. Further studies should be controlled and include the Quality of life (QOL) assessment.

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