Br Homeopath J 2001; 90(03): 118-125
DOI: 10.1054/homp.1999.0476
Original Paper
Copyright © The Faculty of Homeopathy 2001

Homeopathic pathogenetic trials of Acidum malicum and Acidum ascorbicum

P Fisher
a   Royal London Homoeopathic Hospital, UK
F Dantas
b   Federal University of Uberlândia, Brazil
› Author Affiliations

Subject Editor:
Further Information

Publication History

Received24 July 2000
revised06 October 2000

accepted02 February 2001

Publication Date:
28 May 2018 (online)


Two homeopathic pathogenetic trials (HPTs, provings), of identical design were conducted: of Acidum malicum 12 cH and Acidum ascorbicum 12 cH. Each trial included 20 healthy volunteers. Both were of double-blind, placebo-controlled, randomised, four period crossover design, with two sequences. ‘Healthy’ was defined in terms of SF-36 scores, medical judgement and blood tests. All volunteers had regular interviews with the same supervisor. No serious adverse reactions occurred. The causal relationship of each symptom with treatment was judged, blind, by the volunteer, the supervisor and a 9-item pathogenetic index. For Acidum malicum 79 symptoms were identified by the supervisor, 57 were included in the final analysis, 22 occurred in verum treatment periods. For Acidum ascorbicum, of 55 symptoms, 39 were included in the analysis. 16 occurred in verum treatment periods.