Homeopathy 2002; 91(03): 133-144
DOI: 10.1054/homp.2002.0024
Original Paper
Copyright ©The Faculty of Homeopathy 2002

Individualized homeopathic therapy for male infertility

I Gerhard
1   Outpatient Clinic for Complementary Medicine, Department for Gynecological Endocrinology and Reproduction, Gynecological Hospital, University of Heidelberg, Voßstr. 9, D-69115, Heidelberg, Germany
,
E Wallis
1   Outpatient Clinic for Complementary Medicine, Department for Gynecological Endocrinology and Reproduction, Gynecological Hospital, University of Heidelberg, Voßstr. 9, D-69115, Heidelberg, Germany
› Author Affiliations

Subject Editor:
Further Information

Publication History

Received12 November 2001
revised06 February 2002

accepted29 April 2002

Publication Date:
27 December 2017 (online)

Abstract

This prospective observational pilot study investigated the effect of individualized homeopathy on male infertility based on sperm count, hormone values and general health. Forty-five subfertile men were treated with single homeopathic remedies for an average of 10.3 months. The drugs were prescribed on the basis of the overall symptomatic situation. The variables ‘sperm density’, ‘percentage of sperm with good progressive motility’ and ‘density of sperm with good propulsive motility’ improved significantly, especially in cases of oligoasthenozoospermia. The general health of patients improved significantly. The following factors emerged as positive predictors of therapy success: alcohol consumption below 30 g/day, non-smoking, the presence of less than five dental amalgam fillings, no exposure to noxious substances at the workplace and no previous inflammatory genital diseases. The factors stress, age above 36, high coffee consumption and long duration of unwanted childlessness did not have a negative impact on therapy outcome in this study. The rate of improvement in sperm count through homeopathic therapy is comparable to the improvement achieved by conventional therapy, so that individualized-homeopathic treatment may be considered a useful alternative to conventional treatment of subfertile men. For further investigation, a randomised, therapy-controlled clinical study with parallel group design would be useful (homeopathic therapy vs conventional andrological therapy).

 
  • References

  • 1 Haidl G. Der andrologische Sterilitätsfaktor und Möglichkeiten seiner Therapie. Speculum 1993; 2: 3-9.
  • 2 Micic S, Tucic C, Dotcic R. Kallikrein therapy of infertile men with varicocele and impaired sperm motility. Andrologia 1990; 22: 179-183.
  • 3 Keck C, Behre HM, Jockelhövel F, Nieschlag E. Ineffectiveness of kallikrein in treatment of male infertility. Hum Reprod 1994; 2: 325-329.
  • 4 Tournaye H, van Steirteghem AC, Devroey P. Pentoxifylline in idiopathic male-factor infertility. Hum Reprod 1994; 6: 996-1000.
  • 5 Krause W, Holland-Moritz H, Schramm P. Treatment of idiopathic oligozoospermia with tamoxifen. Int J Androl 1992; 15: 14-18.
  • 6 Comhaire F. Conventional treatment of OAT. In: Frick J. (ed). Die Anwendung von GnRH und GnRH-Analoga in der Urologie. 1992. Wien: Blackwell-MZV; 115-123.
  • 7 Gönner, S, Der Therapieeinfluß von Kallikrein, Pentoxiphyllin und Tamoxifen auf das Spermiogramm und die Schwanger-schaftsrate bei andrologischen Fertilitätsstörungen, University of Heidelberg, 1991.
  • 8 Raval, H, C, Goyal, R, K, Effects of multiple homeopathic drug therapy on oligospermia in human subjects: abstract—poster: International Seminar—Traditional Medicine, Calcutta, 1992, 7.05.
  • 9 Gerhard, I, Jung, I, Postneek, F, Effects of acupuncture on semen parameters—hormone profile in infertile men, Molecular Andrology, Chang, M, C, 4, Reproductive Health Center, 78 Surfsong Road, Kiawah Island, South Carolina, USA, 1992, 9, 25.
  • 10 Mishra N. Azoospermia. The Homeopathic Heritage 1992; 8: 517-518.
  • 11 Sonawala S, Mehta B. A case of oligospermia. Ind J Hom Med 1990; 25: 39-40.
  • 12 Bartoov B, Eltes F, Reichart M, Langzam J, Lederman H, Zabludovsky N. Quantitative ultramorphological (QUM) analysis of human sperm: diagnosis and management of male infertility. Arch Androl 1999; 42: 161-177.
  • 13 Glazner A, Kelly NJ, Weir M JA, David J SE, Cornes JS, Hull M RG. The diagnosis of male infertility—prospective timespecific study of conception rates related to seminal analysis and postcoital sperm-mucus-penetration and survival in othervise unexplaind infertility. Hum Reprod 1987; 2: 665-671.
  • 14 Schirren C. Praktische Andrologie. Berlin: Diesbach; 1995. p. 9–29
  • 15 Nieschlag E. WHO-Laborhandbuch zur Untersuchung des menschlichen Ejakulats und der Spermien-Zervikalschleim-Interaktion. Berlin: Springer; 1993. p. 51–53
  • 16 Kent JT. In: von Keller G, von Fimmelsberg K. (eds). Kents Repertorium der homöopathischen Arzneimittel. 7. 1987. Aufl. Heidelberg: Haug;
  • 17 Barthel H. (ed). Synthetic Repertory. Heidelberg: Haug; 1987
  • 18 Klunker, W, (ed), Synthetic Repertory, Heidelberg, Haug, 1987.
  • 19 Boericke OE. Homöopathische Mittel und ihre Wirkungen: materia medica und Repertorium. Leer: Grundlagen und Praxis (Publ.); 1973
  • 20 Mezger J. Gesichtete Homöopathische Arzneimittellehre. Saulgau: Haug; 1985
  • 21 Lathoud JA. Materia Medica. Organon Verl; 1985
  • 22 Kleijnen J, Knipschild P, ter Riet G. Clinical trials of homoeopathy. BMJ 1991; 302: 1601-1606.
  • 23 Linde K, Clausius N, Ramirez G. Are the clinical effects of homoeopathy placebo effects? A meta-analysis of placebo-controlled trials. Lancet 1997; 350: 834-843.
  • 24 Izzo PL, Canale D, Bianchi B. The treatment of male subfertility with kallikrein. Andrologia 1984; 16: 156-161.
  • 25 Haidl G. Morphologische Untersuchungen zur Kallikrein-Wirkung auf die Spermatozoenmotilität. Fertilität 1989; 5: 48-52.
  • 26 Gehring, W, G, Schnieder, U, Krause, W, Cordes, U, Padutin treatment and its effect on semen parameters including Hos and BMP test, 1990.
  • 27 Batterink GJ, Kremer J, Jager S. The effect of oral kallicrein treatment on sperm motility in asthenozoospermie. Int J Androl 1983; 6: 173-179.
  • 28 Comhaire F, Vermeulen L. Effect of high dose kallikrein therapy treatment in men with subfertility. Int J Androl 1983; 6: 168-172.
  • 29 Giovenco P, Amodei M, Barbieri C, Fasani R, Carosi M, Dondero F. Effects of kallikrein on the male reproductive system and its use in the treatment of idiopathic oligozoospermia with impaired motility. Andrologia 1987; 19: 238-241.
  • 30 Maier, U, Eisenmenger, M, Penetration ability of human spermatozoa into standardized bovine cervical mucus in patients with OAT syndrome before and after therapy with Kallikrein, 1990.
  • 31 Marrama P, Baraghini GF, Carani C. Further studies on the effect of pentoxiphylline on sperm count and sperm motility in patients with idiopathic oligo-asthenozoospermia. Andrologia 1995; 17: 612-616.
  • 32 Shen MR, Chiang PH, Yang RC, Hong CY, Chen SS. Pentoxiphylline stimulates human sperm motility both in vitro and after oral therapy. Br J Clin Pharmacol 1991; 31: 711-714.
  • 33 Wang C, Chan CW, Wong KK, Yeung KK. Comparison of the effectiveness of placebo, clomiphen citrat, mesterolone, pentoxiphylline and testosterone rebound therapy for the treatment of idiopathic oligospermia. Fertil Steril 1983; 40: 358-365.
  • 34 Micic S, Hadzi-Djokic J, Dotlic R, Tulic C. Pentoxiphyllin treatment of oligoasthenospermic men. Acta Eur Fertil 1988; 19: 135-137.
  • 35 Gerhard I, Wolfrum C. Kinderwunsch—natürliche Wege zum Baby. Muenchen: Graefe und Unzer; 1998
  • 36 Whorton F, Krauss RM, Marshall S, Milby TH. Infertility in male pesticide workers. Lancet 1977; ii: 1251-1261.
  • 37 Szymczynski GA, Waliszewski SM. Chlorinated pesticide residues in testicular tissue samples, pesticides in human testicles. Andrologi 1983; 15: 696-698.
  • 38 Hilscher W. Umwelt und Fertilität: Ein Beitrag zur Sensibilität der männlichen Keimbahn gegenüber Umweltnoxen. Z Hautkr 1985; 60: 1040-1065.
  • 39 Sinclair S. Male infertility: nutritional and environmental considerations. Altern Med Rev 2000; 5: 28-38.
  • 40 Matthies J, Schwarz I, Donat H. Einfluß von Schwermetallionen auf die männliche Fertilität. Zent Bl Gynäkol 1989; 111: 155-166.
  • 41 Jockenhövel F, Bals-Pratsch M, Bertram HP, Nieschlag E. Seminal lead and copper in fertile and infertile men. Andrologia 1990; 22: 503-511.
  • 42 Donat H, Matthies J, Schwarz I. Fertilität bei Exponierten gegenüber Pflanzenschutz- und Schädlingsbekämpfungs-mitteln. Andrologia 1990; 22: 401-407.
  • 43 Gerhard I, Lenhard K, Eggert-Kruse W, Runnebaum B. Clinical data which influence semen parameters in infertile men. Hum Reprod 1992; 6: 830-837.
  • 44 Sharpe R, Skakkebaek N. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?. Lancet 1993; 341: 1392-1395.
  • 45 Shaarawy M, Mahmoud K. Endocrine profile and semen characteristics in male smokers. Fertil Steril 1982; 38: 255-257.
  • 46 Handelsman DJ, Conway AJ, Boylan LM, Turtle JR. Testicular function in potential sperm donors: normal ranges and the effect of smoking and varicocele. Int J Androl 1984; 7: 369-370.
  • 47 Kauli-Kauskas V, Blaustein D, Ablin R. Cigarette smoking and its possible effects on sperm. Fertil Steril 1985; 44: 526-528.
  • 48 Stillman R, Rosenberg M, Sachs B. Smoking and reproduction. Fertil Steril 1986; 46: 545-566.
  • 49 Gerhard I, Runnebaum B. Schadstoffe und Fertili-tätsstörungen—Genussgifte. Geburtsh Frauenheilk 1992; 52: 509-515.
  • 50 Gerhard I, Fröhlich E, Eggert-Kruse W, Klinga K, Runnebaum B, Petzoldt D. Relationship of sperm acrosin to semen and clinical parameters in infertile patients. Andrologia 1989; 21: 146-154.
  • 51 Anderson Jr RA, Willis BR, Oswald C, Zaneveld LJ. Ethanol-induced male infertility: impairment of spermatozoa. J Pharmacol Exp Ther 1983; 225: 479-486.
  • 52 Nagy F, Pendergrass PB, Bowen DC, Yeager JC. A comparative study of cytological and physiological of semen obtained from alcoholics and non-alcoholics. Alcohol 1986; 21: 17-23.
  • 53 Brzek A. Alcohol and male infertility. Andrologia 1987; 19: 32-36.
  • 54 Mashburn MD, Sloan CS, Hammond MG. Semen quality and association with coffee drinking, cigarette smoking and ethanol consumption. Fertil Steril 1989; 52: 162-165.
  • 55 Gerhard I, Runnebaum B. Schadstoffe und Fertilitäts-störungen: Schwermetalle und Mineralstoffe. Geburtsh Frauenheilk 1992; 52: 383-396.
  • 56 Gerhard I, Monga B, Waldbrenner A, Runnebaum B. Heavy metals and fertility. J Tox Environ Health 1998; 54: 593-611.
  • 57 Mohamed MK, Burbacher TM, Mottet MK. Effects of methylmercury on testicular functions in Macaca fascicularis monkeys. Pharmacol Toxicol 1987; 60: 29-36.
  • 58 Schill WB. In: Runnebaum B, Rabe T. (eds). Gynäkologische Endokrinologie und Fortpflanzungsmedizin. 1994. Berlin: Springer; 287-336.
  • 59 Riegler R, Fischl F, Bunzel B, Neumark J. Korrelation psychischer Veränderungen und Spermiogrammverbes-serungen nach Akupunktur. Urologe A 1984; 23: 329-333.
  • 60 Gerhard I, Keller C, Schmück M. Homöopathische Therapie bei weiblichen Fertilitätsstörungen. T W Gynäkologie 1993; 6: 337-344.
  • 61 Gerhard I, Reimers G, Keller C, Schmück M. Vergleich homöopathischer Einzelmittel mit konventioneller Hormontherapie bei weiblichen Fertilitätsstörungen. Therapeutikon 1993; 7: 309-315.
  • 62 Harrison R, O'Moore R, McSweeney M. Stress, prolactin and infertility. Lancet 1979; 1: 209-210.
  • 63 Koninckx PR. Stress hyperprolactinaemia in clinical practice. Lancet 1978; 1: 273-274.