Zeitschrift für Orthomolekulare Medizin 2018; 16(01): 12-17
DOI: 10.1055/a-0575-2944
© Georg Thieme Verlag KG Stuttgart · New York

Oxidativer Stress und Entzündung als Ursache kardiovaskulärer Erkrankungen

Hans-Peter Friedrichsen
Further Information

Publication History

Publication Date:
23 April 2018 (online)


Erhöhte oxidative Belastung und inflammatorische Aktivität sind entscheidend an der Entstehung von Hypertonie und Arteriosklerose beteiligt. Wichtige Bestandteile von Prävention und Therapie sind Ernährungsmodifikation und ausreichende Zufuhr von Mikronährstoffen wie Arginin, Coenzym Q 10, Vitamin D und Polyphenolen. Auch regelmäßiges Ausdauertraining wirkt über verschiedene Mechanismen kardioprotektiv. Die alleinige Senkung des LDL-Spiegels ist nicht erfolgversprechend.

  • Literatur

  • 1 Vita JA. Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr 2005; 81 (1 Suppl): 292S-297S
  • 2 Mente A, de Koning L, Shannon HS, Anand SS. A systematic review of the evidence upporting a causal link between dietary factors and coronary heart disease. Arch Intern Med 2009; 169 (07) 659-669
  • 3 Jorge MN-C, Miguel AM-G. Antioxidant vitamins and cardiovascular disease. Curr Top Med Chem 2011; 11 (14): 1861-1869
  • 4 Chen CA, Wang TY, Varadharaj S. et al. S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature 2010; 468 (7327): 1115-1118
  • 5 Talukder MA, Johnson WM, Varadharaj S. et al. Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice. Am J Physiol Heart Circ Physiol 2011; 300 (01) H388-396
  • 6 Xia Y, Tsai AL, Berka V, Zweier JL. Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. J Biol Chem 1998; 273 (40) 25804-25808
  • 7 Pimentel D, Haeussler DJ, Matsui R. et al. Regulation of cell physiology and pathology by protein S-glutathionylation: lessons learned from the cardiovascular system. Antioxid Redox Signal 2012; 16 (06) 524-542
  • 8 Eilat-Adar S, Mete M, Fretts A. et al. Dietary patterns and their association with cardiovascular risk factors in a population undergoing lifestyle changes: the Strong Heart Study. Nutr Metab Cardiovasc Dis 2013; 23 (06) 528-535
  • 9 Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003; 78 (3 Suppl): 517S-520S
  • 10 Narasimhulu C, Jiang X, Yang Z, Selvarajan K, Parthasarathy S. Is There a Connection between Inflammation and Oxidative Stress?. In: Roy S. Bagchi D, Raychaudhuri SP. , eds. Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions. Boca Raton/Florida: CRC Press; 2012: 139-152
  • 11 Steinberg D. The LDL modification hypothesis of atherogenesis: An update. J Lipid Res 2009; 50: S376-S381
  • 12 Guzik TJ, West NE, Black E. et al. Vascular superoxide production by NAD(P)H oxidase: Association with endothelial dysfunction and clinical risk factors. Circ Res 2000; 86: E85-E90
  • 13 Lande KE, Sperry WA. Human atherosclerosis in relation to the cholesterol content of the blood serum. Archives of Pathology 1936; 22: 301-312
  • 14 Mathur KS. et al. Serum Cholesterol and Atherosclerosis in Man. Circulation 1961; (23) 847-852
  • 15 Paterson JC, Armstrong R, Armstrong EC. Lipid Serum. Levels and the Severity of Coronary and Cerebral Atherosclerosis in adequately Nourished Men, 60 to 69 Years of Age. Circulation 1963; 27: 229-236
  • 16 Solberg LA. Atherosclerosis IV: Proceedings of the Fourth International Symposium Held in Tokyo, Aug. 24–28, 1976; New York: Springer; 1977
  • 17 Castelli WP. Lipids, risk factors and ischaemic heart disease. Atherosclerosis 1996; 124 (Suppl): S1-9