Fortschr Röntgenstr 2018; 190(11): 1063-1064
DOI: 10.1055/a-0612-7974
The Interesting Case
© Georg Thieme Verlag KG Stuttgart · New York

Ultrasonography and computed tomography findings in pulmonary alveolar microlithiasis

Mustafa Resorlu
Radiology, Canakkale Onsekiz Mart University, Canakkale, Turkey
,
Canan Akgun Toprak
Radiology, Canakkale Onsekiz Mart University, Canakkale, Turkey
,
Nilufer Aylanc
Radiology, Canakkale Onsekiz Mart University, Canakkale, Turkey
,
Ozan Karatag
Radiology, Canakkale Onsekiz Mart University, Canakkale, Turkey
› Author Affiliations
Further Information

Publication History

25 October 2017

29 March 2018

Publication Date:
06 June 2018 (eFirst)

Introduction

Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by intra-alveolar calcium and phosphate deposition. It primarily affects the lungs, although extrapulmonary calcifications or comorbidities may also be seen. Sporadic cases or patients with autosomal recessive familial inheritance have been reported in the literature. The genetic factor implicated in familial cases is mutation in the SLC34A2 gene [Castellana G et al. Eur. Respir Rev. 2015; 24: 607 – 620]. Patients may be asymptomatic despite diffuse radiological involvement, especially in the early period. The most common respiratory symptoms in symptomatic cases are dyspnea, cough, and hemoptysis [Rea G, et al. J Med Ultrason. 2015; 42: 591 –59 4].