Download PDF
CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2018; 78(10): 977-983
DOI: 10.1055/a-0707-6697
GebFra Science
Review/Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Gestational Diabetes – Major New Clinically Relevant Aspects

Article in several languages: English | deutsch
Ute Margaretha Schäfer-Graf
Berliner Diabeteszentrum für Schwangere, Klinik für Gynäkologie und Geburtshilfe, Berlin, Germany
› Author Affiliations
Further Information

Publication History

received 27 July 2018
revised 20 August 2018

accepted 21 August 2018

Publication Date:
19 October 2018 (online)

Also available at
   Permissions and Reprints

Abstract

The implementation of screening for gestational diabetes (GDM) in the German Prenatal Care guidelines of 2012 and the publication of numerous new studies have led to clinically relevant changes in the care of pregnant women with GDM to whom consideration was given in the new S3 Guideline on the Diagnosis, Management and Follow-up of Gestational Diabetes (AWMF 057/008) published in March this year. Certain aspects are addressed and discussed on the basis of additional background information.

Key words

foetal period - gestational diabetes - metabolic defects
 

  • References/Literatur

  • 1 Melchior H, Kurch-Bek D, Mund D. The prevalence of gestational diabetes – a population-based analysis of a nationwide screening program. Dtsch Ärzteblatt Int 2017; 114: 412-416
    PubMedGoogle Scholar
  • 2 Prutsky GJ, Domecq JP, Sundaresh V. et al. Screening for gestational diabetes: A systematic review and meta-analysis. J Clin Endocrinol Metab 2013; 98: 4311-4318
    CrossrefPubMedGoogle Scholar
  • 3 Metzger BE, Dyer AR. Comment on dʼEmden. Do the new threshold levels for the diagnosis of gestational diabetes mellitus correctly identify women at risk?. Diabetes Care 2014; 37: 43-44
    CrossrefPubMedGoogle Scholar
  • 4 Benhalima K, Van Crombrugge P, Moyson C. et al. The sensitivity and specificity of the glucose challenge test in a universal two-step screening strategy for gestational diabetes mellitus using the 2013 WHO Health organisation criteria. Diabetes Care 2018; 41: e111-e112 doi:10.2337/dc18-0556
    CrossrefPubMedGoogle Scholar
  • 5 Farrar D, Duley L, Dowswell T. et al. Different strategies for diagnosing gestational diabetes to improve maternal and infant health. Cochrane Database Syst Rev 2017; (08) CD007122 DOI: 10.1002/14651858.CD007122.pub4.
    CrossrefPubMedGoogle Scholar
  • 6 Tieu J, McPhee AJ, Crowther CA. et al. Screening for gestational diabetes mellitus based on different risk profiles and settings for improving maternal and infant health. Cochrane Database Syst Rev 2017; (08) CD007222 DOI: 10.1002/14651858.CD007222.pub4.
    CrossrefPubMedGoogle Scholar
  • 7 McIntyre HD, Jensen DM, Jensen RC. et al. Gestational Diabetes Mellitus: Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds. Diabetes Care 2018; 41: 1339-1342 doi:10.2337/dc17-2393
    CrossrefPubMedGoogle Scholar
  • 8 Zhu WW, Yang HX, Wei YM. et al. Evaluation of the Value of Fasting Plasma Glucose in the First Prenatal Visit to Diagnose Gestational Diabetes Mellitus in China. Diabetes Care 2013; 36: 586-590
    CrossrefPubMedGoogle Scholar
  • 9 Nauck M, Petermann A, Müller-Wieland D. et al. Definition, Klassifikation und Diagnostik des Diabetes mellitus. Diabetologie und Stoffwechsel 2017; 12 (S02): S94-S100
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Immanuel J, Simmons D. Screening and Treatment for Early-Onset Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis. Curr Diab Rep 2017; 17: 115
    CrossrefPubMedGoogle Scholar
  • 11 Butalia S, Gutierrez L, Lodha A. et al. Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis. Diabet Med 2017; 34: 27-36
    PubMedGoogle Scholar
  • 12 Rowan JA, Rush EC, Obolonkin V. et al. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011; 34: 2279-2284
    CrossrefPubMedGoogle Scholar
  • 13 Tertti K, Eskola E, Ronnemaa T. et al. Neurodevelopment of Two-Year-Old Children Exposed to Metformin and Insulin in Gestational Diabetes Mellitus. J Dev Behav Pediatr 2015; 36: 752-757
    CrossrefPubMedGoogle Scholar
  • 14 Wouldes TA, Battin M, Coat S. et al. Neurodevelopmental outcome at 2 years in offspring of women randomised to metformin or insulin treatment for gestational diabetes. Arch Dis Child Fetal Neonatal Ed 2016; pii:fetalneonatal-2015-309602
    PubMedGoogle Scholar
  • 15 Society of Maternal-Fetal Medicine (SMFM) Publications Committee. Electronic address: pubs@smfm.org. SMFM Statement: Pharmacological treatment of gestational diabetes. Am J Obstet Gynecol 2018; 218: B2-B4
    PubMedGoogle Scholar
  • 16 Rowan JA, Rush EC, Plank LD. et al. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age. BMJ Open Diabetes Res Care 2018; 6: e000456 doi:10.1136/bmjdrc-2017-000456
    CrossrefPubMedGoogle Scholar
  • 17 Niu B, Lee VR, Cheng YW. et al. What is the optimal gestational age for women with gestational diabetes type A1 to deliver?. Am J Obstet Gynecol 2014; 211: 418.e1-418.e6
    CrossrefPubMedGoogle Scholar
  • 18 Sutton AL, Mele L, Landon MB. et al. Delivery timing and cesarean delivery risk in women with mild gestational diabetes mellitus. Am J Obstet Gynecol 2014; 211: 244.e1-244.e7
    CrossrefPubMedGoogle Scholar
  • 19 Boulvain M, Senat MV, Perrotin F. et al. Induction of labour versus expectant management for large-for-date fetuses: A randomised controlled trial. Lancet 2015; 385: 2600-2605
    CrossrefPubMedGoogle Scholar
  • 20 Schäfer-Graf U, Gembruch U, Hösli I. et al. Gestationsdiabetes mellitus (GDM), Diagnostik, Therapie und Nachsorge. Online: https://www.awmf.org/leitlinien/detail/ll/057-008.html Last access: 18.08.2018
    PubMedGoogle Scholar