Exp Clin Endocrinol Diabetes 2020; 128(02): 125-132
DOI: 10.1055/a-0723-3544
Article
© Georg Thieme Verlag KG Stuttgart · New York

Early Growth Hormone Intervention Improves Glucose Metabolism in Adult Rats Born Small for Gestational Age

Yingmin Wang
1   Department of Pediatrics, The First Affliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
2   Department of Endocrinology, Tongde Hospital of Zhejiang Province, Hangzhou, China
,
Weifen Zhu
3   Department of Endocrinology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
,
Lianhui Chen
1   Department of Pediatrics, The First Affliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
,
Li Liang
1   Department of Pediatrics, The First Affliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
› Author Affiliations
Statement of Financial Support: This work was supported by the National Science Foundation of China (Grant No. 81170733), the medicine and health science technology project of Zhejiang Province (Grant No. 2017177741), and Zhejiang Provincial Natural Science Foundation of China (Grant No. LQ18H070001).
Further Information

Publication History

received 31 May 2018
revised   29 July 2018

accepted 29 August 2018

Publication Date:
26 September 2018 (online)

Abstract

Background Small for gestational age (SGA) due to intrauterine malnourishment is closely related to metabolic syndrome and type 2 diabetes mellitus. Growth Hormone (GH) treatment has been demonstrated to influence metabolic parameters and islet function of SGA individuals. The present study demonstrates the effects of early GH treatment on glucose tolerance and expression of pancreatic duodenal homeobox 1 (Pdx1) of SGA rats during adulthood.

Methods SGA rat model was induced by restricting food intake during pregnancy. GH or normal saline was administered during postnatal days 21–35 of SGA rats and appropriate for gestational age (AGA) rats, respectively.

Results In early adulthood (postnatal day 70), as compared to AGA rats, SGA rats showed: (1) decreased body weight; (2) increased postprandial blood glucose; and (3) down-regulated Pdx1 with increased histone deacetylase (HDAC) and down-regulated histone H3-lysine 4 methyltransferase SET7/9. Exogenous GH administration led to a restoration of body weight and normalized glucose tolerance due to an enhanced Pdx1 expression, accompanied by decreased HDAC and up-regulated SET7/9 in SGA rats in early adulthood.

Conclusion Our results demonstrate positive effects on glucose metabolism by an early and short GH treatment in SGA adulthood.

Supplementary Material

 
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