Horm Metab Res 2018; 50(10): 715-727
DOI: 10.1055/a-0749-6655
Review
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Selenium Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis

Motahareh Hasani
1   School of Public Health, Iran University of Medical Sciences,Tehran, Iran
,
Shirin Djalalinia
2   Development of Research & Technology Center, Ministry of Health and Medical Education, Tehran, Iran
3   Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
,
Farshad Sharifi
4   Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
,
Mehdi Varmaghani
3   Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5   Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
,
Maryam Zarei
3   Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
,
Mohammad Esmaeili Abdar
6   Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
,
Hamid Asayesh
7   Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran
,
Mehdi Noroozi
8   Social Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
,
Amir Kasaeian
9   Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
Armita Mahdavi Gorabi
10   Department of Basic and Clinical Research, Tehran University of Medical Sciences, Tehran, Iran
,
Mostafa Qorbani
6   Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
11   Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
› Author Affiliations
Further Information

Publication History

received 09 May 2018

accepted 11 September 2018

Publication Date:
12 October 2018 (online)

Abstract

Selenium is an essential mineral that plays a key role in plenty of major metabolic processes. A growing body of literature has shown that selenium deficiency leads to an increase in plasma TC and TG levels. This study explores the effect of selenium supplementation on serum level of lipid profile [total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low density lipoprotein (VLDL)]. We systematically searched PubMed/MEDLINE, ISI/WOS, and Scopus (from their commencements to Jan 2016) to identify the papers investigating the association between the intake of selenium and lipid profile. Data extracted from the relevant studies were screened. The pooled standardized mean difference was estimated using the random or fixed effects model. Heterogeneity among the studies was assessed using Q-test. Of the potentially relevant articles screened, 11 articles including 1221 participants were included in this meta-analysis. Results of meta-analysis showed that intake of selenium resulted in a statistically significant improvement in TC, [(SMD): –0.13, 95% CI: (–0.24, –0.02)], TG [(SMD): –0.19, 95% CI: (–0.38, –0.01)] and VLDL [(SMD): –0.34, 95% CI: (–0.63, –0.05)]. The selenium supplementation did not significantly improve lipid profile such as LDL [(SMD): –0.08, 95% CI: (–0.036, 0.19)], HDL [(SMD): 0.01, 95% CI: (–0.164, 0.18)], HDL/TC ratio [(SMD): 0.025, 95% CI: (–0.11, 0.16)], non-HDL-C [(SMD): 0.018, 95% CI: (–0.13, 0.16)]. This meta-analysis suggests that the effect of selenium supplementation on the serum levels of TG and VLDL is marginally significant. However, the supplementation has no effect on other serum lipids. Moreover, the study shows that the effect of selenium supplementation on lipid profile is negative.