Z Gastroenterol 2018; 56(12): 1513-1520
DOI: 10.1055/a-0751-3078
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Never seen before? Opisthorchiasis and Clonorchiasis

Imaging parasitic diseasesNoch nie gesehen? Opisthorchiasis und Clonorchiasis Bildgebung parasitärer Erkrankungen
Christoph F. Dietrich
1   Department of Internal Medicine 2, Caritas-Krankenhaus, Bad Mergentheim, Germany
2   Ultrasound Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
,
Nathan S.S. Atkinson
3   Department of Gastroenterology, Waitemata District Health Board, Auckland, New Zealand
,
W. J. Lee
4   Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
,
Kerstin Kling
5   Departement Medizin/Department of Medicine, Swiss Tropical and Public Health Institute
,
Andreas Neumayr
5   Departement Medizin/Department of Medicine, Swiss Tropical and Public Health Institute
,
Barbara Braden
6   Translational Gastroenterology Unit, Oxford University Hospitals, Oxford, UK
,
Joachim Richter
7   Institute of Tropical Medicine and International Health, Charité Universitätsmedizin, Berlin, Germany
,
Robert Akpata
8   Robert Akpata, French national institute of health and medical research (inserm)
,
Phonesavanh Southisavath
5   Departement Medizin/Department of Medicine, Swiss Tropical and Public Health Institute
,
Dagmar Schreiber-Dietrich
9   Department of Pediatrics, Caritas-Krankenhaus, Bad Mergentheim, Germany
,
Yi Dong
10   Department of Ultrasound, Zhongshan Hospital, Fudan University, 200032 Shanghai, China
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Weitere Informationen

Publikationsverlauf

10. Juni 2018

23. September 2018

Publikationsdatum:
22. November 2018 (online)

Abstract

Parasitic diseases are relatively rarely diagnosed and treated in Europe. Therefore, European clinicians are not familiar with their clinical and imaging features. In an era of increased human migration, it is fundamental for clinicians to be able to identify such diseases. We have recently described the features of cystic echinococcosis, schistosomiasis, fascioliasis and ascariasis. Here, we report on the clinical and imaging features as well as on the current therapy options of infections by the small liver flukes: Clonorchis sinensis, Opisthorchis viverrini (Southeast Asian liver fluke) and Opisthorchis felineus (cat liver fluke) and other Opisthorchis species prevalent in South Asia.

Zusammenfassung

Parasitäre Erkrankungen werden in Europa relativ selten diagnostiziert und behandelt. Somit sind auch klinische Besonderheiten und bildgebende Merkmale weniger bekannt. In den Zeiten von Flüchtlingen und weltweiter Migration ist die Kenntnis parasitärer Infektionen zunehmend von Bedeutung und Kliniker müssen in der Lage sein diese zu erkennen. Anhand von klinischen Beschreibungen der Echinokokkose, Schistosomiasis, Fasciolosis und Ascariasis wurden entsprechende Berichte in der Zeitschrift für Gastroenterologie publiziert. In der hier präsentierten Veröffentlichung werden klinische Besonderheiten und Bildgebungsmerkmale der kleinen asiatischen Leberegel diskutiert.

 
  • References

  • 1 Dietrich CF, Lorentzen T, Appelbaum L. et al. EFSUMB guidelines on interventional ultrasound (INVUS), part III – abdominal treatment procedures (long version). Ultraschall Med 2016; 37: E1-E32
  • 2 Dietrich CF, Lorentzen T, Appelbaum L. et al. EFSUMB guidelines on interventional ultrasound (INVUS), part III – abdominal treatment procedures (short version). Ultraschall Med 2016; 37: 27-45
  • 3 Dietrich CF, Mueller G, Beyer-Enke S. Cysts in the cyst pattern. Z Gastroenterol 2009; 47: 1203-1207
  • 4 Richter J, Azoulay D, Dong Y. et al. Ultrasonography of gallbladder abnormalities due to schistosomiasis. Parasitol Res 2016; 115: 2917-2924
  • 5 Richter J, Botelho MC, Holtfreter MC. et al. Ultrasound assessment of schistosomiasis. Z Gastroenterol 2016; 54: 653-660
  • 6 Dietrich CF, Kabaalioglu A, Brunetti E. et al. Fasciolosis. Z Gastroenterol 2015; 53: 285-290
  • 7 Dietrich CF, Sharma M, Chaubal N. et al. Ascariasis imaging: pictorial essay. Z Gastroenterol 2017; 55: 479-489
  • 8 Keiser J, Utzinger J. Food-borne trematodiases. Clin Microbiol Rev 2009; 22: 466-483
  • 9 Lai DH, Hong XK, Su BX. et al. Current status of Clonorchis sinensis and clonorchiasis in China. Trans R Soc Trop Med Hyg 2016; 110: 21-27
  • 10 Control of foodborne trematode infections. Report of a WHO Study Group. World Health Organ Tech Rep Ser 1995; 849: 1-157
  • 11 Andrews RH, Sithithaworn P, Petney TN. Opisthorchis viverrini: an underestimated parasite in world health. Trends Parasitol 2008; 24: 497-501
  • 12 Pakharukova MY, Mordvinov VA. The liver fluke Opisthorchis felineus: biology, epidemiology and carcinogenic potential. Trans R Soc Trop Med Hyg 2016; 110: 28-36
  • 13 Mahanty S, Maclean JD, Cross JH. Liver, lung, and intestinal fluke infections. In: Guerrant RL, Walker DH, Weller PF. eds Tropical Infectious Diseases: Principles, Pathogens and Practice. Philadelphia: Saunders Elsevier; 2011
  • 14 Qian MB, Utzinger J, Keiser J. et al. Clonorchiasis. Lancet 2016; 387: 800-810
  • 15 Rim HJ. Clonorchiasis: an update. J Helminthol 2005; 79: 269-281
  • 16 Wang KX, Zhang RB, Cui YB. et al. Clinical and epidemiological features of patients with clonorchiasis. World J Gastroenterol 2004; 10: 446-448
  • 17 Mordvinov VA, Yurlova NI, Ogorodova LM. et al. Opisthorchis felineus and Metorchis bilis are the main agents of liver fluke infection of humans in Russia. Parasitol Int 2012; 61: 25-31
  • 18 Brassard P, Hoey J, Ismail J. et al. The prevalence of intestinal parasites and enteropathogenic bacteria in James Bay Cree Indians, Quebec. Can J Public Health 1985; 76: 322-325
  • 19 Behr MA, Gyorkos TW, Kokoskin E. et al. North American liver fluke (Metorchis conjunctus) in a Canadian aboriginal population: a submerging human pathogen?. Can J Public Health 1998; 89: 258-259
  • 20 MacLean JD, Arthur JR, Ward BJ. et al. Common-source outbreak of acute infection due to the North American liver fluke Metorchis conjunctus. Lancet 1996; 347: 154-158
  • 21 Richter J, Freise S, Mull R, Millán JC. , and the Triclabendazole Clinical Study Group. Fascioliasis: sonographic abnormalities of the biliary tract and evolution after treatment with triclabendazole.. Trop Med Intern Health 1999; 4: 774-781
  • 22 Millán JC, Mull R, Freise S, Richter J. , and the Triclabendazole Study Group. Efficacy and tolerability of triclabendazol for the treatment of latent and chronic fascioliasis. Am J Trop Med Hyg 2000; 63: 264-269
  • 23 Kabaalioglu A, Ceken K, Alimoglu E. et al. Hepatobiliary fascioliasis: sonographic and CT findings in 87 patients during the initial phase and long-term follow-up. Am J Roentgenol 2007; 189: 824-828 .PMID:17885052
  • 24 Marcos LA, Terashima A, Gotuzzo E. Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis. Curr Opin Infect Dis 2008; 21: 523-530
  • 25 Morsy AT, Al-Mathal EM. Clonorchis sinensis a new report in Egyptian employees returning back from Saudi Arabia. J Egypt Soc Parasitol 2011; 41: 221-225
  • 26 Lewin MR, Weinert MF. An eighty-four-year-old man with fever and painless jaundice: a case report and brief review of Clonorchis sinensis infection. J Travel Med 1999; 6: 207-209
  • 27 Schwartz DA. Cholangiocarcinoma associated with liver fluke infection: a preventable source of morbidity in Asian immigrants. Am J Gastroenterol 1986; 81: 76-79
  • 28 Yossepowitch O, Gotesman T, Assous M. et al. Opisthorchiasis from imported raw fish. Emerg Infect Dis 2004; 10: 2122-2126
  • 29 Sithithaworn P, Haswell-Elkins MR, Mairiang P. et al. Parasite-associated morbidity: liver fluke infection and bile duct cancer in northeast Thailand. Int J Parasitol 1994; 24: 833-843
  • 30 Upatham ES, Viyanant V, Kurathong S. et al. Relationship between prevalence and intensity of Opisthorchis viverrini infection, and clinical symptoms and signs in a rural community in north-east Thailand. Bull World Health Organ 1984; 62: 451-461
  • 31 Mairiang E, Haswell-Elkins MR, Mairiang P. et al. Reversal of biliary tract abnormalities associated with Opisthorchis viverrini infection following praziquantel treatment. Trans R Soc Trop Med Hyg 1993; 87: 194-197
  • 32 Pungpak S, Harinasuta T, Bunnag D. et al. Fecal egg output in relation to worm burden and clinical features in human opisthorchiasis. Southeast Asian J Trop Med Public Health 1990; 21: 275-280
  • 33 Tan WB, Shelat VG, Diddapur RK. Oriental liver fluke infestation presenting more than 50 years after immigration. Ann Acad Med Singapore 2009; 38: 735-736
  • 34 Liu LX, Harinasuta KT. Liver and intestinal flukes. Gastroenterol Clin North Am 1996; 25: 627-636
  • 35 Pungpak S, Chalermrut K, Harinasuta T. et al. Opisthorchis viverrini infection in Thailand: symptoms and signs of infection--a population-based study. Trans R Soc Trop Med Hyg 1994; 88: 561-564
  • 36 Worasith C, Kamamia C, Yakovleva A. et al. Advances in the diagnosis of human opisthorchiasis: development of Opisthorchis viverrini antigen detection in urine. PLoS Negl Trop Dis 2015; 9: e0004157
  • 37 Marti H, Escher E. SAF – an alternative fixation solution for parasitological stool specimens. Schweiz Med Wochenschr 1990; 120: 1473-1476
  • 38 Akai PS, Pungpak S, Chaicumpa W. et al. Serum antibody responses in opisthorchiasis. Int J Parasitol 1995; 25: 971-973
  • 39 Wongsaroj T, Sakolvaree Y, Chaicumpa W. et al. Affinity purified oval antigen for diagnosis of Opisthorchiasis viverrini. Asian Pac J Allergy Immunol 2001; 19: 245-258
  • 40 Lin YL, Chen ER, Yen CM. Antibodies in serum of patients with clonorchiasis before and after treatment. Southeast Asian J Trop Med Public Health 1995; 26: 114-119
  • 41 Wongratanacheewin S, Pumidonming W, Sermswan RW. et al. Detection of Opisthorchis viverrini in human stool specimens by PCR. J Clin Microbiol 2002; 40: 3879-3880
  • 42 Kim EM, Verweij JJ, Jalili A. et al. Detection of Clonorchis sinensis in stool samples using real-time PCR. Ann Trop Med Parasitol 2009; 103: 513-518
  • 43 Umesha KR, Kumar S, Parvathi A. et al. Opisthorchis viverrini: detection by polymerase chain reaction (PCR) in human stool samples. Exp Parasitol 2008; 120: 353-356
  • 44 Hong ST, Yoon K, Lee M. et al. Control of clonorchiasis by repeated praziquantel treatment and low diagnostic efficacy of sonography. Korean J Parasitol 1998; 36: 249-254
  • 45 Elkins DB, Mairiang E, Sithithaworn P. et al. Cross-sectional patterns of hepatobiliary abnormalities and possible precursor conditions of cholangiocarcinoma associated with Opisthorchis viverrini infection in humans. Am J Trop Med Hyg 1996; 55: 295-301
  • 46 Choi D, Hong ST, Lim JH. et al. Sonographic findings of active Clonorchis sinensis infection. J Clin Ultrasound 2004; 32: 17-23
  • 47 Chamadol N, Pairojkul C, Khuntikeo N. et al. Histological confirmation of periductal fibrosis from ultrasound diagnosis in cholangiocarcinoma patients. J Hepatobiliary Pancreat Sci 2014; 21: 316-322
  • 48 Mairiang E, Chaiyakum J, Chamadol N. et al. Ultrasound screening for Opisthorchis viverrini-associated cholangiocarcinomas: experience in an endemic area. Asian Pac J Cancer Prev 2006; 7: 431-433
  • 49 Choi D, Jeon YH, Lee GC. et al. Changes in sonographic findings after treatment of patients with clonorchiasis in a heavy endemic area. Korean J Parasitol 2009; 47: 19-23
  • 50 Kim TY, Lee YS, Yun JH. et al. A case of probable mixed-infection with Clonorchis sinensis and Fasciola sp. CT and parasitological findings. Korean J Parasitol 2010; 48: 157-160
  • 51 Lim JH, Mairiang E, Ahn GH. Biliary parasitic diseases including clonorchiasis, opisthorchiasis and fascioliasis. Abdom Imaging 2008; 33: 157-165
  • 52 Marcos LA, Terashima A, Gotuzzo E. Update on hepatobiliary flukes: fascioliasis, opisthorchiasis and clonorchiasis. Curr Opin Infect Dis 2008; 21: 523-530
  • 53 Jang YJ, Byun JH, Yoon SE. et al. Hepatic parasitic abscess caused by clonorchiasis: unusual CT findings of clonorchiasis. Korean J Radiol 2007; 8: 70-73
  • 54 Liao WC, Wang HP, Chiu HM. et al. Multiple hepatic nodules: rare manifestation of clonorchiasis. J Gastroenterol Hepatol 2006; 21: 1497-1500
  • 55 Leung JW, Yu AS. Hepatolithiasis and biliary parasites. Baillieres Clin Gastroenterol 1997; 11: 681-706
  • 56 Lim JH. Radiologic findings of clonorchiasis. Am J Roentgenol 1990; 155: 1001-1008
  • 57 Choi BI, Kim HJ, Han MC. et al. CT findings of clonorchiasis. Am J Roentgenol 1989; 152: 281-284
  • 58 Choi BI, Park JH, Kim YI. et al. Peripheral cholangiocarcinoma and clonorchiasis: CT findings. Radiology 1988; 169: 149-153
  • 59 Jeong YY, Kang HK, Kim JW. et al. MR imaging findings of clonorchiasis. Korean J Radiol 2004; 5: 25-30
  • 60 Dolay K, Hasbahceci M, Hatipoglu E. et al. Endoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection. Ulus Travma Acil Cerrahi Derg 2018; 24: 71-73
  • 61 Mahmood T, Mansoor N, Quraishy S. et al. Ultrasonographic appearance of Ascaris lumbricoides in the small bowel. J Ultrasound Med 2001; 20: 269-274
  • 62 Mohamadnejad M, Al-Haddad MA, MoayyedKazemi A. et al. Biliary fascioliasis diagnosed by EUS. Gastrointest Endosc 2016; 83: 658-659
  • 63 Senates E, Dogan A, Senates BE. et al. An incidental case of biliary fascioliasis mimicking cholangiocellular carcinoma. Infez Med 2014; 22: 313-316
  • 64 Bosnak VK, Karaoglan I, Sahin HH. et al. Evaluation of patients diagnosed with fascioliasis: a six-year experience at a university hospital in Turkey. J Infect Dev Ctries 2016; 10: 389-394
  • 65 Lukambagire AH, McHaile DN, Nyindo M. Diagnosis of human fascioliasis in Arusha region, northern Tanzania by microscopy and clinical manifestations in patients. BMC Infect Dis 2015; 15: 578
  • 66 Teke M, Onder H, Cicek M. et al. Sonographic findings of hepatobiliary fascioliasis accompanied by extrahepatic expansion and ectopic lesions. J Ultrasound Med 2014; 33: 2105-2111
  • 67 Lim JH, Mairiang E, Ahn GH. Biliary parasitic diseases including clonorchiasis, opisthorchiasis and fascioliasis. Abdom Imaging 2008; 33: 157-165
  • 68 Mayumi T, Okamoto K, Takada T. et al. Tokyo Guidelines 2018: management bundles for acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci 2018; 25: 96-100
  • 69 European Association for theStudy of the Liver. EASL Clinical Practice Guidelines: the diagnosis and management of patients with primary biliary cholangitis. J Hepatol 2017; 67: 145-172
  • 70 Poomphakwaen K, Promthet S, Kamsa-Ard S. et al. Risk factors for cholangiocarcinoma in Khon Kaen, Thailand: a nested case-control study. Asian Pac J Cancer Prev 2009; 10: 251-258
  • 71 Chaiyadet S, Sotillo J, Smout M. et al. Carcinogenic liver fluke secretes extracellular vesicles that promote cholangiocytes to adopt a tumorigenic phenotype. J Infect Dis 2015; 212: 1636-1645
  • 72 Okuda K, Kubo Y, Okazaki N. et al. Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma: a study of 57 autopsy-proven cases. Cancer 1977; 39: 232-246
  • 73 Handbook of Antimicrobial Therapy, 20th ed. The Medical Letter. NY: New Rochelle; 2015
  • 74 Jong EC, Wasserheit JN, Johnson RJ. et al. Praziquantel for the treatment of clonorchis/opisthorchis infections: report of a double-blind, placebo-controlled trial. J Infect Dis 1985; 152: 637-640
  • 75 Tinga N, De N, Vien HV. et al. Little effect of praziquantel or artemisinin on clonorchiasis in Northern Vietnam. A pilot study. Trop Med Int Health 1999; 4: 814-818
  • 76 Bunnag D, Harinasuta T. Studies on the chemotherapy of human opisthorchiasis: III. Minimum effective dose of praziquantel. Southeast Asian J Trop Med Public Health 1981; 12: 413-417
  • 77 Pungpak S, Bunnag D, Harinasuta T. Clinical and laboratory evaluation of praziquantel in opisthorchiasis. Southeast Asian J Trop Med Public Health 1983; 14: 363-366
  • 78 Sayasone S, Meister I, Andrews JR. et al. Efficacy and safety of praziquantel against light infections of Opisthorchis viverrini: a randomized parallel single-blind dose-ranging trial. Clin Infect Dis 2017; 64: 451-458
  • 79 Pungpark S, Bunnag D, Harinasuta T. Albendazole in the treatment of opisthorchiasis and concomitant intestinal helminthic infections. Southeast Asian J Trop Med Public Health 1984; 15: 44-50
  • 80 Liu YH, Wang XG, Gao P. et al. Experimental and clinical trial of albendazole in the treatment of Clonorchiasis sinensis. Chin Med J (Engl) 1991; 104: 27-31
  • 81 Jaroonvesama N, Charoenlarp K, Cross JH. Treatment of Opisthorchis viverrini with mebendazole. Southeast Asian J Trop Med Public Health 1981; 12: 595-597
  • 82 Soukhathammavong P, Odermatt P, Sayasone S. et al. Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial. Lancet Infect Dis 2011; 11: 110-118
  • 83 Qian MB, Yap P, Yang YC. et al. Efficacy and safety of tribendimidine against Clonorchis sinensis. Clin Infect Dis 2013; 56: e76-82
  • 84 Sayasone S, Odermatt P, Vonghachack Y. et al. Efficacy and safety of tribendimidine against Opisthorchis viverrini: two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials. Lancet Infect Dis 2016; 16: 1145-1153
  • 85 Jongsuksuntigul P, Imsomboon T. The impact of a decade long opisthorchiasis control program in northeastern Thailand. Southeast Asian J Trop Med Public Health 1997; 28: 551-557
  • 86 Jongsuksuntigul P, Imsomboon T. Epidemiology of opisthorchiasis and national control program in Thailand. Southeast Asian J Trop Med Public Health 1998; 29: 327-332
  • 87 Viravan C, Bunnag D, Harinasuta T. et al. Clinical field trial of praziquantel in opisthorchiasis in Nong Rangya Village, Khon Kaen Province, Thailand. Southeast Asian J Trop Med Public Health 1986; 17: 63-66
  • 88 Vivatanasesth P, Sornmani S, Schelp FP. et al. Mass treatment of opisthorchiasis in Northeast Thailand. Southeast Asian J Trop Med Public Health 1982; 13: 609-613