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Int J Sports Med 2019; 40(02): 125-132
DOI: 10.1055/a-0809-5408
Training & Testing
© Georg Thieme Verlag KG Stuttgart · New York

Reproducibility of Inert Gas Rebreathing Method to Estimate Cardiac Output at Rest and During Cardiopulmonary Exercise Stress Testing

Autoren

  • Nduka Charles Okwose

    1   Institute of Cellular Medicine, Newcastle university, Newcastle Upon Tyne, United Kingdom of Great Britain and Northern Ireland

  • Jie Zhang

    2   Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

  • Shakir Chowdhury

    1   Institute of Cellular Medicine, Newcastle university, Newcastle Upon Tyne, United Kingdom of Great Britain and Northern Ireland

  • David Houghton

    3   Institute of Neuroscience, Newcastle university, Newcastle Upon Tyne, United Kingdom of Great Britain and Northern Ireland

  • Srdjan Ninkovic

    4   Department of Surgery, University of Kragujevac and Clinical Centre Kragujavac, Kragujevac, Serbia

  • Saša Jakovljević

    5   Faculty for Sport and Physical Education, Тheory and methodology of Basketball, Belgrade, Serbia

  • Branislav Jevtic

    6   Faculty of Sport and Physical Education, University of Belgrade, Belgrade, Serbia

  • Robert Ropret

    6   Faculty of Sport and Physical Education, University of Belgrade, Belgrade, Serbia

  • Christopher Eggett

    7   Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom of Great Britain and Northern Ireland
    8   Newcastle Upon Tyne Hospitals NHS Foundation Trust, Echocardiography, Newcastle Upon Tyne, United Kingdom of Great Britain and Northern Ireland

  • Matthew Bates

    9   James Cook University Hospital, Cardiothoracic Department, Middlesbrough, United Kingdom of Great Britain and Northern Ireland

  • Guy MacGowan

    1   Institute of Cellular Medicine, Newcastle university, Newcastle Upon Tyne, United Kingdom of Great Britain and Northern Ireland
    10   Newcastle Upon Tyne Hospitals NHS Foundation Trust, Cardio-thoracic Department, Newcastle Upon Tyne, United Kingdom of Great Britain and Northern Ireland

  • Djordje Jakovljevic

    1   Institute of Cellular Medicine, Newcastle university, Newcastle Upon Tyne, United Kingdom of Great Britain and Northern Ireland
    11   Newcastle Upon Tyne Hospitals NHS Foundation Trust, Cardiovascular Sciences, Newcastle Upon Tyne, United Kingdom of Great Britain and Northern Ireland
    12   Newcastle University Centre for Ageing and Vitality, Clinical Exercise Physiology, Newcastle Upon Tyne, United Kingdom of Great Britain and Northern Ireland
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Publikationsverlauf



accepted 16. November 2018

Publikationsdatum:
03. Januar 2019 (online)

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Abstract

The present study evaluated reproducibility of the inert gas rebreathing method to estimate cardiac output at rest and during cardiopulmonary exercise testing. Thirteen healthy subjects (10 males, 3 females, ages 23–32 years) performed maximal graded cardiopulmonary exercise stress test using a cycle ergometer on 2 occasions (Test 1 and Test 2). Participants cycled at 30-watts/3-min increments until peak exercise. Hemodynamic variables were assessed at rest and during different exercise intensities (i. e., 60, 120, 150, 180 watts) using an inert gas rebreathing technique. Cardiac output and stroke volume were not significantly different between the 2 tests at rest 7.4 (1.6) vs. 7.1 (1.2) liters min−1, p=0.54; 114 (28) vs. 108 (15) ml beat−1, p=0.63) and all stages of exercise. There was a significant positive relationship between Test 1 and Test 2 cardiac outputs when data obtained at rest and during exercise were combined (r=0.95, p<0.01 with coefficient of variation of 6.0%), at rest (r=0.90, p<0.01 with coefficient of variation of 5.1%), and during exercise (r=0.89, p<0.01 with coefficient of variation 3.3%). The mean difference and upper and lower limits of agreement between repeated measures of cardiac output at rest and peak exercise were 0.4 (−1.1 to 1.8) liter min−1 and 0.5 (−2.3 to 3.3) liter min−1, respectively. The inert gas rebreathing method demonstrates an acceptable level of test-retest reproducibility for estimating cardiac output at rest and during cardiopulmonary exercise testing at higher metabolic demands.

Key words

cardiac output - cardiopulmonary exercise testing - inert gas rebreathing